Biostatistics Core

生物统计学核心

• 批准号: 10230146
• 负责人: Brooke L Fridley
• 金额: $ 0.45万
• 依托单位: H. LEE MOFFITT CANCER CTR & RES INST
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-02-18 至 2022-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10230146
• 关键词: Applications Grants; Applied Research; Basic Science; Biometry; Biostatistical Methods; Biostatistics Core; Cancer Center; Cancer Center Support Grant; Certification; Clinical; Clinical Trials; Clinical Trials Design; Collaborations; Conduct Clinical Trials; Core Facility; Data; Development; Ensure; Faculty; Funding; Gene Expression Profiling; Gene Mutation; Goals; Grant; Hour; Individual; Institutional Review Boards; Intervention Studies; Lung; Manuscripts; Mentors; Methods; Modeling; Monitor; Mutation Analysis; Observational Study; Peer Review; Play; Population Sciences; Postdoctoral Fellow; Preparation; Protocols documentation; Publications; Regression Analysis; Research; Research Design; Research Personnel; Research Project Grants; Research Support; Resources; Review Committee; Role; Sample Size; Scientist; Services; Skin; Statistical Data Interpretation; Statistical Methods; Supervision; Survival Analysis; Therapeutic Clinical Trial; Training; Training and Education; Work; behavioral study; data resource; design; faculty research; graduate student; investigator training; lectures; meetings; member; novel; phase II trial; programs; research study; tissue resource; tool; trial design

PROJECT SUMMARY The overall goal of the Biostatistics Core (BC) is to provide statistical design and analysis expertise supporting the research efforts of Moffitt Cancer Center (MCC) members. Service begins with analytical design and determination of sample size (e.g., grant and clinical trial submissions), leading to project conduct, monitoring of accumulating research data on active projects, and manuscript development. The BC provides key quantitative analytical results, including tables, figures, and scientific conclusions. Faculty biostatisticians provide education and training in biostatistics, participate actively in the Scientific Review Committees (SRC) and Protocol Review & Monitoring Committee (PRMC), and serve as reviewers for internal grant applications. The BC's Specific Aims are to: 1) Support members by providing high-quality biostatistical design and analysis services; 2) Educate and train investigators on biostatistical resources and tools; and 3) Develop and implement methods for state-of-the-art statistical analyses. The BC also supports the conduct of research through involvement on various oversight committees (e.g., SRC and PRMC). The BC includes nine faculty, seven staff biostatisticians, a Core Facility Manager and a Project Manager. Faculty biostatisticians dedicate 50% to 60% of their effort to the BC and are supported by grant funding, revenue from clinical trials, and institutional support. Staff biostatisticians and the Core Facility Manager are dedicated to the BC and are supported by chargebacks, revenue from clinical trials, and institutional support. BC faculty and staff are involved at all stages of scientific research, from study design to publication of research findings. Most BC efforts involve BC faculty-staff teams. During the past funding cycle, the BC played significant roles in both the Lung and Skin SPORE grants. In addition, BC biostatisticians are part of every investigator-initiated therapeutic clinical trial conducted at MCC. Over the past five years, the BC has supported over 500 clinical trials, research efforts across all five research programs, and research projects that have received SRC approval. In the most recent fiscal year, the BC supported 78 members, with 75% of usage for peer-reviewed-funded members. There are two BC faculty members on each of four SRCs and the PRMC.

项目摘要 生物统计学核心（BC）的总体目标是提供统计设计和分析专业知识， 莫菲特癌症中心（MCC）成员的研究成果。服务始于分析设计， 样本大小的确定（例如，赠款和临床试验提交），导致项目实施，监测 积累活跃项目的研究数据和手稿开发。BC提供关键 定量分析结果，包括表格、数字和科学结论。生物统计学家 提供生物统计学方面的教育和培训，积极参加科学审查委员会（SRC） 和方案审查和监测委员会（PRMC），并担任内部赠款申请的审查员。 BC的具体目标是：1）通过提供高质量的生物统计设计和分析来支持成员 服务; 2）教育和培训生物统计资源和工具的研究人员;以及3）开发和 实施最先进统计分析方法。不列颠哥伦比亚省还支持进行研究 通过参与各种监督委员会（例如，SRC和PRMC）。 BC包括九名教师，七名生物统计学家，一名核心设施经理和一名项目经理。 学院生物统计学家将50%至60%的精力投入到BC，并得到赠款资金的支持， 来自临床试验的收入和机构支持。生物统计学家和核心机构经理是 专门用于BC，并由退款、临床试验收入和机构支持提供支持。 BC的教职员工参与了科学研究的各个阶段，从研究设计到出版， 研究结果。大多数业务连续性工作涉及业务连续性教职员工团队。在过去的融资周期中，BC发挥了 在肺和皮肤孢子赠款中发挥重要作用。此外，BC生物统计学家是每个 在MCC进行的药物启动的治疗性临床试验。 在过去的五年里，BC已经支持了500多项临床试验，所有五项研究的研究工作 计划和研究项目已获得SRC批准。在最近一个财政年度，BC 支持了78个成员，其中75%的使用率为同行评审资助的成员。有两个BC教师 四个SRC和PRMC的成员。