Safe Magnetic Resonance Imaging of Patients with Deep Brain Stimulation Systems

使用深部脑刺激系统对患者进行安全磁共振成像

• 批准号: 10226910
• 负责人: Yigitcan Eryaman
• 金额: $ 41.75万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-08-01 至 2025-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10226910
• 关键词: Acute; Affect; Age; Animals; Applications Grants; Bilateral; Cadaver; Clinical; Complex; Data; Deep Brain Stimulation; Deposition; Devices; Disease; Electrodes; Electromagnetic Fields; Electromagnetics; Ensure; Family suidae; Freedom; Future; General Population; Goals; Head; Heating; Histology; Human; Image; Imaging technology; Implant; Implanted Electrodes; Institutional Review Boards; Location; MRI Scans; Magnetic Resonance Imaging; Measures; Medical Device; Medicine; Methods; Monitor; Morphologic artifacts; Neuromodulator; Patient imaging; Patients; Pattern; Performance; Phase; Physiologic pulse; Public Health; Research; Resistance; Safety; Scanning; Scheme; Secure; Slice; System; Temperature; Time; Tissues; Work; absorption; base; brain tissue; experimental study; high resolution imaging; human subject; imaging modality; implant design; implantable device; implantation; improved; medical implant; metallicity; models and simulation; neural implant; performance tests; radio frequency; simulation; transmission process; voltage

Project Summary Every 5 minutes, a patient is denied an MRI scan because of an active implanted medical device. Therefore, there is a clinical need to improve the safety of MRI scans to allow patients with implants to be imaged. Ability to safely scan patients with implants would have an overall public health impact. If we can develop a safe framework to be used to image these patients, we will be able to use MRI to monitor the stage of their diseases and the efficacy of their treatment. In this project we aim to develop a workflow that utilizes multi-channel and receiver arrays in order to safely image patients with Deep Bran Stimulators (DBS). We will utilize a pre-scan strategy (accelerated by parallel acquisition) to calculate RF current induced on DBS leads and predict electrode tip temperature. We are going to calculate/design implant friendly excitation solutions/pTx pulses and utilize them to reduce RF heating around the DBS electrodes. We will demonstrate the temperature reduction around the DBS leads using fluoroscopic probes and evaluate image quality. We will test the performance of our approach by scanning phantoms, anesthetized animals (swine) and human cadavers. We will finally scan human subjects implanted with full DBS systems (electrode, extension, IPG) using the methods developed in this proposal.

项目摘要 每5分钟，就有一名患者因有源植入医疗器械而被拒绝接受MRI扫描。因此，我们认为， 临床上需要改进MRI扫描的安全性，以允许对具有植入物的患者进行成像。能力 安全地扫描植入植入物的患者将对整体公共卫生产生影响。如果我们能开发出一种安全的 一旦有了一个用于对这些患者进行成像的框架，我们将能够使用MRI来监测他们的疾病阶段 以及治疗的效果 在这个项目中，我们的目标是开发一个工作流程，利用多通道和接收器阵列，以安全地 使用深部麸皮刺激器（DBS）对患者进行成像。我们将利用预扫描策略（通过并行加速 采集），以计算DBS电极导线上感应的射频电流并预测电极头端温度。我们将 计算/设计植入物友好型激发溶液/pTx脉冲，并利用它们减少射频加热 在DBS电极周围我们将使用以下方法证明DBS电极导线周围的温度降低 透视探头和评价图像质量。我们将通过扫描来测试我们方法的性能 幻影、麻醉动物（猪）和人尸体。我们将最终扫描植入人体的受试者 使用本提案中开发的方法，使用完整DBS系统（电极、延伸导线、IPG）。