Safe Magnetic Resonance Imaging of Patients with Deep Brain Stimulation Systems

项目摘要 每隔5分钟，就会有一名患者因为植入了活跃的医疗设备而被拒绝接受核磁共振扫描。因此， 临床上有必要提高MRI扫描的安全性，以便对植入植物的患者进行成像。能力 对患者进行安全的植入物扫描将对整体公共健康产生影响。如果我们能开发出一种安全的 框架用于对这些患者进行成像，我们将能够使用MRI来监测他们的疾病分期 以及他们的治疗效果。 在这个项目中，我们的目标是开发一种利用多通道和接收器阵列的工作流，以便安全地 想象使用深麸皮刺激剂(DBS)的患者。我们将利用预扫描策略(由并行加速 采集)以计算DBS引线上感应的射频电流并预测电极尖端温度。我们要走了 计算/设计植入型友好激励解决方案/PTX脉冲，并利用它们减少射频加热 在DBS的电极周围。我们将使用以下工具演示DBS引线周围的降温 透视探头和评估图像质量。我们将通过扫描来测试我们方法的性能 幻影、麻醉动物(猪)和人类身体。我们最终将扫描植入人体的受试者 使用本提案中开发的方法，使用完整的DBS系统(电极、延伸、IPG)。

Project Summary Every 5 minutes, a patient is denied an MRI scan because of an active implanted medical device. Therefore, there is a clinical need to improve the safety of MRI scans to allow patients with implants to be imaged. Ability to safely scan patients with implants would have an overall public health impact. If we can develop a safe framework to be used to image these patients, we will be able to use MRI to monitor the stage of their diseases and the efficacy of their treatment. In this project we aim to develop a workflow that utilizes multi-channel and receiver arrays in order to safely image patients with Deep Bran Stimulators (DBS). We will utilize a pre-scan strategy (accelerated by parallel acquisition) to calculate RF current induced on DBS leads and predict electrode tip temperature. We are going to calculate/design implant friendly excitation solutions/pTx pulses and utilize them to reduce RF heating around the DBS electrodes. We will demonstrate the temperature reduction around the DBS leads using fluoroscopic probes and evaluate image quality. We will test the performance of our approach by scanning phantoms, anesthetized animals (swine) and human cadavers. We will finally scan human subjects implanted with full DBS systems (electrode, extension, IPG) using the methods developed in this proposal.