Motor and multisystem symptom clusters in children with Autism Spectrum Disorder (ASD): A SPARK dataset study

项目总结 运动障碍在患有自闭症谱系障碍(ASD)的学龄儿童中普遍存在；然而，他们 往往被忽视，仍然得不到诊断和治疗。大约87%的火花儿童 自闭症谱系障碍(ASD)是美国最大的自闭症队列，有运动障碍/DCD的风险 根据发展协调障碍问卷(BHAT，2020)的调查结果。然而，马达 根据《诊断和统计手册》，损害不是ASD诊断标准或指标的一部分 《精神障碍》，第5版(DSM-V)。 尽管运动领域被添加到精神障碍的NIMH研究领域标准(RDoC)中只是最后一次 一年来，电机问题没有作为ASD的RDoC的一部分进行讨论。目前还不清楚是否有一种独特的模式 运动障碍和多系统障碍(运动、社交和重复行为)是 在患有自闭症的儿童中存在。这些损害模式是否会在ASD范围内改变某些亚 表型或者是跨性别、年龄、共病诊断和损害程度的泛化？ 在建议的项目中，我们将研究运动障碍、自闭症严重程度和 自闭症儿童的合并症。具体来说，我们将确定患有以下疾病的儿童运动障碍的风险 以及随着社交障碍、重复行为严重程度的增加， 使用父母报告测量：DCD-Q，社交沟通的合并症和损害程度 问卷(SCQ)和重复行为量表修订版(RBS-R)。我们的分析还将提供进一步的 ASD儿童普遍但独特的运动障碍模式的证据，如果存在， 存在ASD的多系统症状群和亚型。 我们还将强调有差别地获得各种治疗(OT、PT、娱乐性)儿童的问题 以及如何与儿童运动障碍的风险无关，从而揭示诊断不足和 使用PT和娱乐疗法对ASD患者的运动问题进行不足的治疗。随着COVID危机的演变和 我们等待可靠的治疗方法和疫苗，恢复儿科面对面的研究将需要很长时间。vbl.使用 因此，像Spark研究数据集这样的大型数据库来回答关键的研究问题是及时和 必不可少的。

PROJECT SUMMARY Motor impairments are pervasive in school-age children with Autism Spectrum Disorder (ASD); however, they are often ignored and remain undiagnosed and untreated. Approximately 87% of the SPARK cohort of children with Autism Spectrum Disorder (ASD), the largest ASD cohort in the US, is at-risk for a motor impairment/DCD based on findings from the Developmental Coordination Disorder (DCD) Questionnaire (Bhat, 2020). Yet, motor impairments are not part of the diagnostic criteria or specifiers for ASD per the Diagnostic and Statistical Manual of Mental Disorders, 5th edition (DSM-V). Although motor domain was added to the NIMH research domain criteria (RDoC) for mental disorders only last year, motor issues have not been discussed as part of the RDoC for ASD. It is unclear if a unique pattern of motor impairments and multisystem impairments (motor, social communication, and repetitive behavior) are present in children with ASD. Do these patterns of impairment change across the ASD spectrum for certain sub- phenotypes or are they generalized across sex, age, comorbid diagnoses, and levels of impairment? In the proposed project, we will study the associations between motor impairment, autism severity, and comorbidities in children with ASD. Specifically, we will determine the risk for motor impairment in children with ASD and how that changes with increasing social communication impairment, repetitive behavior severity, comorbidities, and levels of impairment using parent report measures: DCD-Q, Social Communication Questionnaire (SCQ), and Repetitive Behavior Scale-Revised (RBS-R). Our analyses will also provide further evidence for generalized but unique patterns of motor impairments in children with ASD and if present, the presence of multisystem symptom clusters and sub-phenotypes of ASD. We will also highlight the issue of differential access to various therapies (OT, PT, recreational) for children with ASD and how those do not relate to a child’s risk for motor impairment, thus revealing under-diagnosis and under-treatment for motor issues in ASD using PT and recreational therapies. As the COVID crisis evolves and we wait for reliable treatments and vaccines, resuming pediatric face to face research will take a long time. Using large databases such as the SPARK study dataset to answer critical research questions is therefore, timely and essential.