ETG-4000 Optical Topography System

ETG-4000光学形貌系统

• 批准号: 9074999
• 负责人: Anjana Narayan Bhat
• 金额: $ 52.83万
• 依托单位: UNIVERSITY OF DELAWARE
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-02-01 至 2017-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9074999
• 关键词: Adult; Affect; Area; Autistic Disorder; Behavior; Behavior Therapy; Behavioral; Biological Models; Brain; Brain Injuries; Cerebral Palsy; Child; Childhood; Chronic low back pain; Clinical Research; Data; Delaware; Development; Down Syndrome; Elderly; Electroencephalography; Electrophysiology (science); Equilibrium; Functional Magnetic Resonance Imaging; Funding; Individual; Infant; Locomotion; Motor; Movement; Neurorehabilitation; Oppositional Defiant Disorder; Optics; Patients; Play; Population; Positioning Attribute; Psychopathology; Request for Proposals; Research Personnel; Short-Term Memory; Stroke; Symptoms; System; Technology; Translational Research; United States National Institutes of Health; Universities; Walking; Work; arm function; base; brain behavior; cognitive neuroscience; high risk infant; infrared spectroscopy; interdisciplinary collaboration; interest; named group; neuroimaging; neuromechanism; programs; psychosocial; relating to nervous system; social

 DESCRIPTION (provided by applicant): Currently we have multiple ongoing NIH funded studies at the University of Delaware (UD) to examine the effects of various behavioral interventions developed for pediatric and adult neurologically affected special populations. We feel there is an urgent need to understand the neural mechanisms of change underlying the behavioral improvements we notice in our populations of interest. Additionally, we are interested in studying the neural substrates for a wide range of behaviors that are an area of emphasis for NIH including working memory in children with Autism, interpersonal synchrony in children with Autism and Oppositional Defiant Disorder, balance in children with Cerebral Palsy, mobility in children with Down Syndrome, arm function in infants with Brain Injury, locomotion in patients with Stroke, and psychosocial symptoms related to Chronic Low Back Pain in older adults. In this proposal, we are requesting funds to purchase a Hitachi functional infrared spectroscopy (fNIRS) system (Model: ETG-4000) to advance our clinical and translational research programs as well as interdisciplinary collaborations between researchers working in the areas of pediatric/adult neurorehabilitation, developmental psychopathologies, and motor, social, and cognitive neuroscience. Common neuroimaging approaches such as functional Magnetic Resonance Imaging (fMRI) and electrophysiological approaches such as Electroencephalography (EEG) are limited to tasks in reclined or seated positions with minimal to no movement, making these applications ineffective in obtaining brain activation data in the presence of movement and during naturalistic interactions. If the fNIRS system were to become available at UD, it would allow us to examine part or whole brain activation during a variety of functional motor tasks such as reaching and walking as well as naturalistic and play-based interactions between individuals. This makes the fNIRS technology truly translational and transformational in understanding brain-behavior relationships within real-world settings when working with a diverse set of pediatric and adult special populations including Adult with Stroke and Chronic Low Back Pain, Children with Autism, Cerebral Palsy, Oppositional Defiant Disorder, and Down Syndrome as well as High-risk infants.

 描述（由申请人提供）：目前，我们在特拉华大学 (UD) 正在进行多项 NIH 资助的研究，以检验针对儿童和成人神经系统受影响的特殊人群开发的各种行为干预措施的效果。我们认为迫切需要了解我们在感兴趣的人群中注意到的行为改善背后的神经变化机制。此外，我们有兴趣研究 NIH 重点关注的广泛行为的神经基础，包括自闭症儿童的工作记忆、自闭症和对立违抗性障碍儿童的人际同步性、脑瘫儿童的平衡性、唐氏综合症儿童的活动能力、脑损伤婴儿的手臂功能、中风患者的运动能力以及与慢性腰背相关的心理社会症状 老年人的疼痛。在本提案中，我们请求资金购买日立功能红外光谱 (fNIRS) 系统（型号：ETG-4000），以推进我们的临床和转化研究项目，以及儿科/成人神经康复、发育精神病理学以及运动、社会和认知神经科学领域研究人员之间的跨学科合作。常见的神经成像方法（例如功能性磁共振成像（fMRI））和电生理学方法（例如脑电图（EEG））仅限于倾斜或坐姿且几乎没有运动的任务，使得这些应用程序在存在运动和自然交互期间无法有效获取大脑激活数据。如果 UD 能够使用 fNIRS 系统，我们将能够在各种功能性运动任务（例如伸手和行走以及个体之间的自然和基于游戏的互动）期间检查部分或整个大脑的激活。这使得 fNIRS 技术在与各种儿科和成人特殊人群（包括患有中风和慢性腰痛的成人、患有自闭症、脑瘫、对立违抗性障碍和唐氏综合症以及高危婴儿）合作时，在了解现实世界环境中的大脑行为关系方面具有真正的转化和变革作用。

项目成果

fNIRS-Based Differences in Cortical Activation during Tool Use, Pantomimed Actions, and Meaningless Actions between Children with and without Autism Spectrum Disorder (ASD).

• DOI: 10.3390/brainsci13060876
• 发表时间: 2023-05-29
• 期刊: BRAIN SCIENCES
• 影响因子: 3.3
• 作者: Su, Wan-Chun;Culotta, McKenzie;Mueller, Jessica;Tsuzuki, Daisuke;Bhat, Anjana
• 通讯作者: Bhat, Anjana