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Investigating Implications of E-Cigarettes on Pregnancy Success and Reproductive Fitness

Investigating Implications of E-Cigarettes on Pregnancy Success and Reproductive Fitness
研究电子烟对怀孕成功和生殖健康的影响
批准号:
10401483
负责人:
Margeaux Wetendorf Marbrey
金额:
$10.16万
依托单位国家:
美国
项目类别:
财政年份:
2021
资助国家:
美国
项目状态:
已结题
起止时间:
2021-05-05 至 2023-01-31
关键词:
AffectAgonistArteriesBenchmarkingBiological ProcessBuffersCXCL12 geneCXCR4 geneCell Differentiation processCell physiologyCellsCessation of lifeCigaretteCommunity HealthComplexDangerousnessDataDeciduaDelayed Embryo ImplantationElectronic Nicotine Delivery SystemsElectronic cigaretteEmbryoEmbryo TransferEmbryonic DevelopmentEndometrialEnzymesEpithelialEventExhibitsExposure toFacultyFertilityFertility RatesFetal DeathFetal Growth RetardationFetal WeightFetal healthFlavoringFoundationsGene ExpressionGoalsHormonalHumanImmuneImpairmentIn VitroInfertilityInhalationInvadedKnowledgeLiquid substanceLitter SizeMeasuresMediatingModelingMolecularMusNicotineOrganoidsPathologyPathway interactionsPatientsPlacentaPlacentationPositioning AttributePregnancyPregnant WomenProcessPropylene GlycolsProstaglandinsPublic HealthPublishingRecurrenceRegulationReportingResearchResourcesSafetySamplingSignal PathwaySignal TransductionSpiral Artery of the EndometriumSpontaneous abortionStromal CellsSupplementationSystemTestingTimeTissuesToxic effectUterusVascular PermeabilitiesVegetablesVitamin E AcetateWomanaerosolizedantagonistchemokinechemokine receptorcigarette smokingearly pregnancyearly pregnancy losselectronic cigarette useexperienceexperimental studyfailure Implantationfetalhormonal signalshypertensiveimmunoregulationimplantationimprovedin vitro Modelin vivoknock-downmalformationnatural Blastocyst Implantationpregnancy disorderprotein expressionrecruitreproductive fitnessreproductive system disordersmoking during pregnancysuccesstenure tracktoxicanttranscriptomicstrophoblastuterine receptivityvaporvegetable glycerin

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英文摘要
Project Summary/Abstract Electronic nicotinic delivery systems (ENDS) or e-cigarettes are widely used in the nation today, despite a paucity of information regarding their safety. In particular, ENDS usage by pregnant women is prevalent, as cigarette smoking during pregnancy is associated with miscarriage and fetal death. However, little is known regarding the safety of ENDS use during pregnancy. ENDS is made up of a liquid containing a mixture of propylene glycol and vegetable glycerine with additions of flavorings, nicotine, and thickening agents that is heated, aerosolized, and inhaled. Supplementation of ENDS with flavors and thickening agents can dramatically enhance the toxicity level and thus, impair fine-tuned biological processes such as pregnancy. At the start of pregnancy, the uterine stroma and epithelium communicate in a complex orchestration of molecular and hormone signaling events to coordinate the implantation of an embryo. After implantation, the fetal-derived trophoblast cells invade into the maternal tissue to remodel the spiral arteries, initiating the formation of the placenta. My recently published data was the first to describe that ENDS exposure elongated the timing of pregnancy and caused a delay in embryo implantation. I also determined ENDS exposure elicited a dramatic transcriptomic shift at the time of implantation. However, no studies have further examined the mechanism causing implantation delay. ENDS exposure was identified to impair trophoblast cell function in vitro, yet no in vivo studies have examined placental development. Although most ENDS users enjoy the addition of flavors, no studies have examined ENDS with flavor usage or thickening agents on pregnancy. Thus, there is an urgent need to further examine how ENDS can influence pregnancy. This proposal aims to 1.) test how ENDS with additives affects fertility and placental development, 2.) investigate the ENDS-driven mechanisms resulting in delayed implantation using an in vitro human epithelial organoid model, and 3.) determine the timing and cause of in vivo ENDS-induced delayed embryo implantation. This proposal provides a detailed plan to examine how ENDS regulates fertility and early pregnancy success and proposes to validate ENDS-mediated molecular mechanisms delaying implantation. This study can advise the public on the measure of caution observed for ENDS usage in pregnancy and can expand our understanding of mechanisms that regulate implantation success, benefitting women experiencing infertility or recurrent implantation failure.
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DOI: 10.1530/rep-23-0017
发表时间: 2023-07-01
期刊: Reproduction (Cambridge, England)
影响因子: --
作者: [Marbrey MW, Douglas ES, Goodwin ER, Caron KM]
通讯作者: Caron KM
Investigating Implications of E-Cigarettes on Pregnancy Success and Reproductive Fitness
  • 批准号:
    10866972
  • 项目类别:
  • 资助金额:
    $24.73万
  • 财政年份:
    2021
  • 负责人:
    Margeaux Wetendorf Marbrey
  • 依托单位:
Investigating Implications of E-Cigarettes on Pregnancy Success and Reproductive Fitness
  • 批准号:
    10190069
  • 项目类别:
  • 资助金额:
    $10.16万
  • 财政年份:
    2021
  • 负责人:
    Margeaux Wetendorf Marbrey
  • 依托单位:
国内基金
海外基金
Agonist-GPR119-Gs复合物的结构生物学研究
  • 批准号:
    32000851
  • 项目类别:
    青年科学基金项目
  • 资助金额:
    24.0万元
  • 批准年份:
    2020
  • 负责人:
    乔安娜
  • 依托单位: