Translating an Efficacious Illness Management Intervention for African American Youth with Poorly Controlled Asthma to Real World Settings

将针对哮喘控制不佳的非裔美国青年的有效疾病管理干预措施应用到现实世界中

• 批准号: 10227125
• 负责人: DEBORAH A. ELLIS
• 金额: $ 60.06万
• 依托单位: WAYNE STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-08-20 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10227125
• 关键词: 17 year old; Accident and Emergency department; Adherence; Admission activity; Adolescent; Adoption; Affect; African American; Algorithms; Area; Asthma; Caring; Child; Child health care; Childhood Asthma; Chronic Disease; Cities; Clinical; Clinical Pathways; Clinical Trials; Collaborations; Communities; Community Health Aides; Cost Analysis; Cost Savings; Development; Dose; Education; Effectiveness; Emergency Care; Emergency department visit; Emergency medical service; Evidence based intervention; Evidence based practice; Family; Funding; Future; Guidelines; Health; Health Care Costs; Health Professional; Healthcare; Home; Home visitation; Hospitalization; Hospitals; Individual; Intervention; Intervention Studies; Literature; Measures; Medicaid; Mental Health; Methodology; Methods; Michigan; Minority; Morbidity - disease rate; Outcome; Patient Care; Patients; Pediatric Hospitals; Pharmaceutical Preparations; Policies; Procedures; Process Measure; Provider; Psychotherapy; Quality of life; Randomized Clinical Trials; Reporting; Risk; Schools; Self Management; Services; Specific qualifier value; Symptoms; System; Testing; Training; Training and Education; Translating; Translational trial; United States Dept. of Health and Human Services; Use Effectiveness; Visit; Vulnerable Populations; Youth; adherence rate; age group; asthma exacerbation; base; care providers; cost; cost estimate; design; dissemination research; effectiveness evaluation; effectiveness implementation study; effectiveness testing; effectiveness trial; evidence base; experience; family support; follow-up; health care availability; health care service; health care settings; health disparity; health plan; high risk; high-risk adolescents; implementation barriers; implementation facilitators; implementation intervention; implementation research; improved; inner city; innovation; minority children; mortality; pediatric emergency; programs; pulmonary function; quality assurance; randomized effectiveness trial; screening; skills training; standard care; tool

There is a critical need to develop interventions to reduce barriers to optimal asthma management and reduce the significant risk for asthma-related morbidity experienced by minority children, especially African- American adolescents with poorly controlled asthma. There are few clinical trials focusing on African-American adolescents with poorly controlled asthma, and intervention studies targeting African-American adolescents with asthma in general or African-American children with poorly controlled asthma in particular are characterized by methodological limitations and/or limited effects on objective health outcomes. Multisystemic Therapy-Health Care (MST-HC) is an intensive, multi-component, home-based psychotherapy that targets the multiple causes of poor adolescent asthma management across individual, family and community systems. In a randomized clinical trial, we showed that MST-HC was significantly more effective than home-based family support in improving adherence to controller medications and improving lung functioning among African- American adolescents with moderate to severe, poorly controlled asthma up to six months after the completion of the intervention. In addition, MST-HC reduced asthma-related hospitalizations and associated ED visits. The primary purpose of the proposed study is to adapt MST-HC for use in real world, public healthcare settings and test it in a T3 translational trial. The new intervention, Reach for Control (RFC), will be housed in a pediatric emergency department (ED) at Children's Hospital of Michigan (CHM)and will be adapted for delivery by community health workers (CHWs). The design is an effectiveness-implementation “Hybrid 1” design where the primary aims are to determine the effectiveness of an evidence-based intervention in a real-world setting, and the secondary aims are to gather information about the context for implementation and barriers/ facilitators to implementation. For our effectiveness aim, we will conduct a randomized effectiveness trial with 170 high risk adolescents with poorly controlled asthma seen in the ED for an asthma exacerbation. RFC will be delivered by Wayne Children's Healthcare Access Program, a community agency providing health care services to underserved children in the Detroit area and will be compared to the agency's standard care intervention for youth with poorly controlled asthma. For our implementation aims, we will evaluate the effectiveness of identification, screening and referral to RFC by ED clinical staff via a clinical pathway. We will study barriers and facilitators to the implementation of RFC (both its integration within the ED and delivery by CHWs) using a mixed methods approach. We will also develop and evaluate an efficient and effective method of measuring CHW fidelity to RFC and conduct a cost analysis that will inform decisions such as treatment dose and CHW caseload in future real-world implementations. If successful, the study has the potential to improve quality of life for a vulnerable population while reducing healthcare costs.

迫切需要制定干预措施，以减少最佳哮喘管理和 减少少数族裔儿童，特别是非洲儿童患哮喘相关疾病的重大风险 患有哮喘控制不良的美国青少年。很少有针对非裔美国人的临床试验 哮喘控制不佳的青少年，以及针对非裔美国青少年的干预研究 患有哮喘的儿童，特别是哮喘控制不佳的非裔美国儿童 具有方法局限性和/或对客观健康结果影响有限的特点。多系统 治疗-保健(MST-HC)是一种强化的，多成分的，以家庭为基础的心理治疗，目标是 个人、家庭和社区系统对青少年哮喘管理不善的多种原因。在……里面 一项随机临床试验表明，MST-HC明显比以家庭为基础的家庭更有效 支持改善非洲人对控制器药物的依从性和改善肺功能- 美国青少年中到重度哮喘，完成后六个月内控制不佳 干预的结果。此外，MST-HC减少了与哮喘相关的住院和相关的急诊就诊。 拟议研究的主要目的是使MST-HC适用于现实世界的公共医疗保健环境 并在T3翻译试验中对其进行测试。新的干预措施，Reach for Control(RFC)，将被安置在一个 密歇根儿童医院(CHM)的儿科急诊科(ED)，将改装用于分娩 由社区卫生工作者(CHW)提供。该设计是一种有效实施“混合1”设计，其中 主要目的是确定以证据为基础的干预在现实世界环境中的有效性， 次要目标是收集有关执行环境和障碍/促进者的信息 到实施。为了我们的有效性目标，我们将进行170高的随机有效性试验 在急诊室看到的哮喘控制不佳的青少年有哮喘恶化的风险。RFC将成为 由提供医疗保健的社区机构韦恩儿童医疗保健访问计划提供 为底特律地区未得到充分服务的儿童提供的服务，并将与该机构的标准护理进行比较 对哮喘控制不佳的青少年的干预。就我们的推行目标而言，我们会评估 急诊科临床工作人员通过临床途径识别、筛查和转诊至RFC的有效性。我们会 研究实施RFC的障碍和促进者(包括其在教育部门的整合和通过以下方式交付 CHWS)使用混合方法。我们还将开发和评估一种有效的方法 衡量CHW对RFC的忠诚度，并进行成本分析，为治疗等决策提供信息 在未来的真实世界实施中，DIGN和CHW的案例工作量很大。如果成功，这项研究有可能 提高弱势群体的生活质量，同时降低医疗成本。

项目成果

Evaluating barriers and facilitators to healthcare providers' use of an emergency department electronic referral portal for high-risk children with asthma using the Theoretical Domains Framework.

使用理论领域框架评估医疗保健提供者使用急诊科电子转诊门户来治疗高危哮喘儿童的障碍和促进因素。

• DOI: 10.1080/02770903.2023.2257318
• 发表时间: 2024
• 期刊: The Journal of asthma : official journal of the Association for the Care of Asthma
• 作者: Shukla,Meghna;Carcone,April;Mooney,Michael;Kannikeswaran,Nirupama;Ellis,DeborahA
• 通讯作者: Ellis,DeborahA