Indoor and outdoor light at night: Associations with sleep and breast cancer

夜间室内和室外光：与睡眠和乳腺癌的关联

• 批准号: 10230773
• 负责人: Marina Rose Sweeney
• 金额: $ 3.48万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-08-01 至 2022-06-05
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10230773
• 关键词: Academic Training; Acting Out; Address; Air Pollutants; Area; Binomial Model; Breast Cancer Risk Factor; Breast Carcinogenesis; Cancer Etiology; Censuses; Characteristics; Circadian Dysregulation; Circadian Rhythms; Cohort Studies; Confidence Intervals; Cox Proportional Hazards Models; Data; Databases; Development; Diagnosis; Dreams; Drowsiness; Enrollment; Environment; Environmental Epidemiology; Environmental Exposure; Environmental Risk Factor; Epidemiologic Methods; Epidemiology; Estrogen Receptor Status; Estrogen receptor positive; Exposure to; Fellowship; Future; Geography; Goals; Green space; Habitats; Individual; Inflammation; Joints; Knowledge; Lead; Life Style; Light; Link; Malignant Neoplasms; Measures; Medical History; Melatonin; Menopausal Status; Mentors; Mentorship; Metabolic; Meteorology; Methods; Modeling; Modification; Napping; Neighborhoods; Noise; North Carolina; Obesity; Participant; Pathway interactions; Patient Self-Report; Poison; Policies; Population Analysis; Prevalence; Prospective cohort; Prospective cohort study; Regulation; Research; Risk; Risk Factors; Role; Running; Services; Sister; Sleep; Sleep Deprivation; Sleep disturbances; Source; System; Training; Universities; Urbanization; Woman; Work; breast cancer diagnosis; cancer epidemiology; cancer risk; demographics; deprivation; doctoral student; epidemiology study; experience; fine particles; follow-up; genetic risk factor; hazard; high risk; indexing; innovation; interest; land cover; malignant breast neoplasm; mortality; pre-doctoral; programs; prospective; reproductive; residence; sleep difficulty; sleep onset; sleep quality; sleep quantity; study population

PROJECT SUMMARY Applicant. The goal of this F31 fellowship application is to support and promote the training of Marina Sweeney, who is currently a pre-doctoral student in the Department of Epidemiology at the University of North Carolina, Chapel Hill. Her long-term research interests focus on elucidating the role of the environment on cancer risk. The applicant will be mentored by Drs. Hazel Nichols and Alexandra White during the F31 training period. Significance. Breast cancer is the most common malignancy diagnosed in women in the US, and known risk factors are estimated to explain only half of incident cases. Risk of breast cancer may be increased by poor quality or insufficient sleep through mechanisms of inflammation and obesity. Outdoor and indoor light at night (LAN) are proposed to disrupt circadian rhythms and thereby negatively impact sleep and possibly increase the risk of breast cancer. Prior studies suggest that outdoor LAN increases breast cancer risk, while studies of indoor LAN have been mixed. Outdoor and indoor LAN have been shown to disrupt sleep, but few large-scale epidemiologic studies have been conducted. Assessments of outdoor or indoor LAN individually may misclassify LAN exposure, and no studies have assessed combined outdoor and indoor LAN exposure in relation to either breast cancer or sleep characteristics. The overall goal of the proposed study is to further our knowledge of the role of LAN in breast carcinogenesis and sleep disruption. Aim 1. Examine the association between outdoor, indoor, and combined LAN and risk of incident breast cancer. Aim 2. Examine the association between outdoor, indoor, and combined LAN and sleep duration and quality. Approach. The Sister Study prospective cohort includes 50,884 women who had a sister with breast cancer but who themselves were breast-cancer free at baseline. Outdoor LAN will be determined from satellite data and linked to baseline geocoded addresses. Indoor LAN was self-reported at baseline. Aim 1 will use Cox proportional hazards models to calculate hazard ratios and 95% confidence intervals for the associations between indoor and outdoor LAN and breast cancer risk. Aim 2 will use weighted log binomial models to calculate prevalence ratios and 95% confidence intervals for associations between LAN and characteristics of sleep duration and quality. Innovation. The proposed project capitalizes on existing data within the Sister Study and will incorporate existing and new geospatial variables (outdoor LAN, neighborhood SES index, area deprivation index, fine particulate matter, green space, noise) in a prospective cohort of >50,000 US women. This will be the first study to assess joint outdoor and indoor LAN in relation to either breast cancer or sleep characteristics. Impact. The proposed study will provide the applicant with further training in epidemiologic methods, including the integration of both geographic and individual exposure data, and provide high-quality mentorship and numerous professional development opportunities.

项目摘要 申请人。F31奖学金申请的目的是支持和促进玛丽娜的培训。 斯威尼目前是北方大学流行病学系的博士预科生， 卡罗莱纳，查佩尔山。她的长期研究兴趣集中在阐明环境对 癌症风险。申请人将在F31培训期间接受Hazel Nichols博士和Alexandra白色博士的指导 期意义乳腺癌是美国女性中最常见的恶性肿瘤， 据估计，已知的风险因素只能解释一半的事件。乳腺癌的风险可能会增加 通过炎症和肥胖机制导致睡眠质量差或睡眠不足。室外和室内照明 在夜间（LAN）被认为会扰乱昼夜节律，从而对睡眠产生负面影响， 增加患乳腺癌的风险。先前的研究表明，户外局域网增加乳腺癌的风险，而 对室内LAN的研究有好有坏。室外和室内局域网已被证明会扰乱睡眠，但很少有人 进行了大规模的流行病学研究。单独评估室外或室内LAN 可能会对LAN暴露进行错误分类，并且没有研究评估户外和室内LAN暴露的组合， 与乳腺癌或睡眠特征有关。拟议研究的总体目标是进一步促进我们的 了解LAN在乳腺癌发生和睡眠中断中的作用。目标1。检查协会 室外、室内和混合LAN与乳腺癌发病风险之间的关系。目标二。检查 室外、室内和组合LAN与睡眠持续时间和质量之间的关联。Approach.妹子 研究前瞻性队列包括50，884名妇女，她们的姐妹患有乳腺癌，但她们自己 基线时无乳腺癌。室外局域网将根据卫星数据确定，并与基线相关联 地理编码地址。在基线时自我报告室内LAN。目标1将使用考克斯比例风险 模型来计算室内和室内环境之间的关联的风险比和95%置信区间， 户外局域网和乳腺癌的风险。目标2将使用加权对数二项模型计算患病率 和95%的置信区间之间的关联LAN和睡眠时间和质量的特点。 创新拟议的项目利用了姐妹研究中的现有数据， 现有的和新的地理空间变量（室外局域网，邻里SES指数，面积剥夺指数，罚款 颗粒物、绿色空间、噪声）。这将是第一 研究评估联合室外和室内局域网与乳腺癌或睡眠特征的关系。 冲击拟议的研究将为申请人提供流行病学方法的进一步培训，包括 整合地理和个人暴露数据，并提供高质量的指导， 众多的专业发展机会。