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The role of type 2 diabetes on skeletal muscle atrophy and recovery following bed rest in older adults

2 型糖尿病对老年人卧床休息后骨骼肌萎缩和恢复的作用

基本信息

批准号：
10231270
负责人：
Paul Martin Coen
金额：
$ 70.33万
依托单位：
ADVENTHEALTH ORLANDO
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-09-01 至 2023-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10231270
关键词：
3-Dimensional Acute Age Aging Atrophic Bed rest Biochemical Bioenergetics Biology Biopsy Body mass index Calcium Cardiolipins Ceramides Clinical Complication Data Development Diabetes Mellitus Disuse Atrophy Elderly Etiology Exercise Goals Health Hospitalization Human Immobilization Impairment In Situ Injury Insulin Resistance Intervention Investigation Label Link Lipids Measurement Mitochondria Molecular Molecular Target Muscle Muscle function Muscular Atrophy Non-Insulin-Dependent Diabetes Mellitus Outcome Patients Phenotype Physical Function Physical activity Physiological Play Pre-Clinical Model Predisposition Protein Biosynthesis Proteomics Public Health Reactive Oxygen Species Recovery Respiration Role Shotguns Skeletal Muscle Sphingolipids Stimulus Testing Time clinically relevant evidence base experience improved in vivo innovation lipid metabolism lipidomics mitochondrial dysfunction muscle form muscle strength novel oxidation precision medicine prevent programs response sarcopenia skeletal muscle wasting therapeutically effective

项目摘要

PROJECT SUMMARY Loss of muscle mass during periods of disuse due to illness or hospitalization and poor recovery have serious health consequences for older adults. The mechanisms underlying the atrophy response to disuse and subsequent recovery in humans, however, are not known. We posit that poor mitochondrial energetics and altered muscle lipid metabolism contribute to greater disuse- induced muscle atrophy and poor recovery. In addition, we believe that older subjects with type 2 diabetes have reduced mitochondria capacity and excess muscle lipids, which exacerbates the deleterious effect of bed rest on muscle mass and impairs recovery. Mitochondria play a fundamental role in muscle health and impaired mitochondrial energetics and muscle lipids have been shown to contribute to human aging and type 2 diabetes. The role of mitochondrial energetics in human muscle atrophy and recovery is not known. In this project, we will test the hypothesis that altered mitochondrial energetics in muscle atrophy and recovery via cardiolipin remodeling, elevated reactive oxygen species (ROS) emission and accumulation of specific muscle sphingolipids blunt anabolic stimuli and contribute to muscle atrophy and poor recovery. The overall objective of this project is to decipher mechanisms by which mitochondrial energetics and muscle lipids underlie early muscle catabolic and anabolic responses to disuse and recovery. Studying older adults with type 2 diabetes and using an exercise recovery program will provide a physiological context and will allow us to delineate novel mechanisms. Through innovative time course studies and measurements in serial human muscle biopsies, we will place the etiology of muscle atrophy firmly in the context of mitochondrial biology and will contribute to a better precision medicine approach to prevent and treat disuse atrophy.

项目概要由于疾病或住院而停用期间肌肉质量的损失以及恢复不良会造成严重的后果对老年人的健康影响。对废用和萎缩反应的潜在机制然而，人类随后的恢复情况尚不清楚。我们认为，线粒体能量差和肌肉脂质代谢改变会导致更大的废用。引起肌肉萎缩，恢复不良。此外，我们认为患有 2 型糖尿病的老年受试者线粒体容量减少和肌肉脂质过多，加剧了卧床的有害影响依靠肌肉质量休息并损害恢复。线粒体在肌肉健康和线粒体能量学和肌肉脂质受损中发挥着重要作用已被证明会导致人类衰老和 2 型糖尿病。线粒体能量学的作用人体肌肉的萎缩和恢复尚不清楚。在这个项目中，我们将测试改变的假设通过心磷脂重塑、活性氧升高，肌肉萎缩和恢复中的线粒体能量学特定肌肉鞘脂的物种（ROS）发射和积累会减弱合成代谢刺激和导致肌肉萎缩和恢复不良。该项目的总体目标是破译线粒体能量学和肌肉的机制脂质是早期肌肉对废用和恢复的分解代谢和合成代谢反应的基础。研究老年人患有 2 型糖尿病并使用运动恢复计划将提供生理背景，并允许我们来描绘新颖的机制。通过连续人类的创新时间过程研究和测量肌肉活检，我们将把肌肉萎缩的病因牢固地置于线粒体生物学的背景下，将有助于采用更好的精准医学方法来预防和治疗废用性萎缩。