Driving Biomedical Projects

推动生物医学项目

• 批准号: 10406895
• 负责人: JEFFREY C HOCH
• 金额: $ 24.4万
• 依托单位: UNIVERSITY OF CONNECTICUT SCH OF MED/DNT
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-01 至 2025-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10406895
• 关键词: Address; Archives; Automation; Automobile Driving; Bayesian Analysis; Biological; Biomolecular Nuclear Magnetic Resonance; Clinical; Communities; Complement; Complex; Computer software; Computers; Data; Data Analyses; Drug Screening; Ensure; Environment; Face; Frequencies; Funding; Goals; Health; Membrane; Molecular; Molecular Structure; Names; Performance; Proteins; Relaxation; Reproducibility; Research; Research Personnel; Resolution; Running; Services; Source; Testing; Time; Translations; analytical method; computational platform; computer infrastructure; computerized data processing; computing resources; data management; data reduction; drug discovery; improved; innovation; metabolomics; mimetics; novel; small molecule; solid state; structural biology; technology development; tool

Abstract: Driving Biological Projects. DBPs ensure that the TRDs address challenges posed by ongoing, funded research on important biomedical problems. The DBP applications include protein structural biology, NMR relaxation studies of biomolecular dynamics, and NMR metabolomics, including a clinical project. The DBPs present challenges that can be addressed using computation as well as offering opportunities for greater advances enabled through novel software and high-performance computation. While the challenges for clinical metabolomics projects are similar to other metabolomics projects, clinical projects have regulatory burdens associated with protected health information (PHI). Developing a HIPPA-compliant instance of NMRbox presents new challenges, but extends the utility of NMRbox to a new constituency, investigators employing NMR in clinical settings. !

摘要：推动生物项目。 DBP 确保 TRD 应对持续的、 资助重要生物医学问题的研究。 DBP 应用包括蛋白质结构生物学、 生物分子动力学的 NMR 弛豫研究和 NMR 代谢组学，包括临床项目。这 DBP 提出了可以通过计算来解决的挑战，并提供了实现更大目标的机会。 通过新颖的软件和高性能计算实现的进步。虽然临床面临挑战 代谢组学项目与其他代谢组学项目类似，临床项目有监管负担 与受保护的健康信息 (PHI) 相关。开发符合 HIPPA 标准的 NMRbox 实例 提出了新的挑战，但将 NMRbox 的实用性扩展到了新的领域，研究人员采用 临床环境中的核磁共振。 ！