Breast Oncology Program
Breast Oncology Program
批准号:
10406945
负责人:
Laura J Van't Veer
金额:
$8.73万
依托单位国家:
美国
项目类别:
财政年份:
1999
资助国家:
美国
项目状态:
已结题
起止时间:
1999-08-05 至 2023-05-31
关键词:
AgeBiologicalBiologyBreast Cancer Risk FactorBreast OncologyCDC2 geneCDK2 geneCancer Center Support GrantCancer EtiologyCaringCessation of lifeClinical TrialsDevelopmentDiagnosticDirect CostsDiseaseERBB2 geneERBB3 geneEpithelial-Stromal CommunicationFundingGoalsHarm ReductionHealthcareHeterogeneityHomeostasisImageIndividualInterventionKnowledgeMalignant - descriptorMalignant NeoplasmsMammographic DensityMammographyMetabolismMissionMolecularOutcomePIM1 genePathway interactionsPatientsPeer ReviewPhysiologicalPredispositionProcessPublicationsRadiation exposureResearch PersonnelRisk EstimateSan FranciscoSchoolsScienceTherapeuticTissuesToxic effectWomanWorkbasecheckpoint modulationcostdisorder riskdrug developmenthigh riskimmune checkpointimprovedimproved outcomeindividualized medicineinnovationmalignant breast neoplasmmammography registrynew therapeutic targetoncology programovertreatmentpersonalized diagnosticspersonalized screeningpreventprogramsrandomized trialroutine screeningscreeningsuccesstooltreatment responsetrial designtriple-negative invasive breast carcinoma
中文摘要
乳腺肿瘤学项目:总结
乳腺肿瘤学(BR)计划的使命是开发创新方法来描述
乳腺癌易感性、异质性、多样性和差异性的分子和细胞网络
目的是改善健康妇女和乳腺癌妇女的预后。BR计划
工作旨在通过个性化筛查和治疗减少过度诊断和过度治疗,
以更低的成本获得更好的结果。BR计划通过四个主题实现其目标:
主题1:在微环境背景下提高对乳腺癌病因学的理解
主题2:个性化筛查和诊断以增加医疗保健价值
主题3:确定高危疾病的新治疗靶点
主题4:通过创新试验设计提高药物开发效率
BR计划:关键步骤
成员(14个部门,3所学校)33
整整18
助理15
与癌症有关的供资(截至2009年的直接费用)
14 454 243美元
2017年05月31日)
NCI 5,307,970美元37%
同行评审$4,630,302 32%
非同行评审4,515,971美元31%
癌症相关出版物(1/2012-7/2017)636
方案间
方案内
高影响力190 30%
临床试验应计费用(2016年)5293 58
治疗140 31
其他干预措施9 4
非干预性
英文摘要
Breast Oncology Program: Summary
The mission of the Breast Oncology (BR) Program is to develop innovative approaches to describe the
molecular and cellular networks underlying breast cancer susceptibility, heterogeneity, diversity, and disparities
with the aim of improving outcomes for healthy women and women with breast cancer. The BR Program's
work aims to reduce overdiagnosis and overtreatment through individualizing screening and treatment, and
derive better outcomes at lower cost. The BR Program achieves its goals through four themes:
Theme 1: Improving the Understanding of Breast Cancer Etiology in the Context of the Microenvironment
Theme 2: Personalizing Screening and Diagnostics to Increase Health Care Value
Theme 3: Identifying New Therapeutic Targets for High-risk Disease
Theme 4: Augmenting Efficiency of Drug Development through Innovative Trial Design
BR Program: Key Metrics
Membership (14 departments, 3 schools) 33
Full 18
Associate 15
Cancer-relevant Funding (direct costs as of
$14,454,243
05/31/2017)
NCI $5,307,970 37%
Peer-reviewed $4,630,302 32%
Non-peer-reviewed $4,515,971 31%
Cancer-relevant Publications (1/2012-7/2017) 636
Inter-programmatic 141 22%
Intra-Programmatic 175 28%
High-Impact 190 30%
Accruals to Clinical Trials (2016) 5293 58
Therapeutic 140 31
Other Interventional 9 4
Non-interventional 5144 22
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Project 3: Characterization of the biology of non-responders using Imaging and molecular analysis to inform treatment
-
批准号:10628611
-
项目类别:
-
资助金额:$86.58万
-
财政年份:2017
-
负责人:Laura J Van't Veer
-
依托单位:
Project 03 - Understanding the biology of non-responders to inform treatment selection
-
批准号:10249156
-
项目类别:
-
资助金额:$15.94万
-
财政年份:2017
-
负责人:Laura J Van't Veer
-
依托单位:
Project 03 - Understanding the biology of non-responders to inform treatment selection
-
批准号:10013139
-
项目类别:
-
资助金额:$22.87万
-
财政年份:2017
-
负责人:Laura J Van't Veer
-
依托单位:
Breast Oncology Program
-
批准号:10712665
-
项目类别:
-
资助金额:$18.33万
-
财政年份:1999
-
负责人:Laura J Van't Veer
-
依托单位:
SPORE in Breast Cancer
-
批准号:8250847
-
项目类别:
-
资助金额:$230.0万
-
财政年份:1997
-
负责人:Laura J Van't Veer
-
依托单位:
SPORE in Breast Cancer
-
批准号:8039212
-
项目类别:
-
资助金额:$190.23万
-
财政年份:1997
-
负责人:Laura J Van't Veer
-
依托单位:
Project 03 - Understanding the biology of non-responders to inform treatment selection
-
批准号:9560699
-
项目类别:
-
资助金额:$29.68万
-
财政年份:--
-
负责人:Laura J Van't Veer
-
依托单位:
Breast Oncology Program
-
批准号:9784179
-
项目类别:
-
资助金额:$1.07万
-
财政年份:--
-
负责人:Laura J Van't Veer
-
依托单位:
Project 03 - Understanding the biology of non-responders to inform treatment selection
-
批准号:9789201
-
项目类别:
-
资助金额:$28.1万
-
财政年份:--
-
负责人:Laura J Van't Veer
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依托单位:
海外基金