Breast Oncology Program

乳腺肿瘤学项目：综述 乳腺肿瘤学(BR)项目的使命是开发创新的方法来描述 乳腺癌易感性、异质性、多样性和差异性背后的分子和细胞网络 旨在改善健康妇女和患有乳腺癌的妇女的结局。BR计划的 工作的目的是通过个性化的筛查和治疗来减少过度诊断和过度治疗，以及 以更低的成本获得更好的结果。BR计划通过四个主题实现其目标： 主题1：在微环境的背景下提高对乳腺癌病因的理解 主题2：个性化筛查和诊断以增加医疗保健价值 主题3：为高危疾病确定新的治疗目标 主题4：通过创新的试验设计提高药物开发效率 Br计划：关键指标 会员(14个系，3所学校)33 全额18 助理15 与癌症相关的资金(截至 14,454,243美元 2017/05/31) NCI$5,307,970 37% 同行评审4,630,302美元32% 非同行评审4,515,971美元31% 癌症相关出版物(2012/1-7/2017)636 方案间14122% 方案内175 28% 高影响力190 30% 临床试验应计费用(2016)5293 58 治疗性140 31 其他干预措施9 4 非干预性5144 22

Breast Oncology Program: Summary The mission of the Breast Oncology (BR) Program is to develop innovative approaches to describe the molecular and cellular networks underlying breast cancer susceptibility, heterogeneity, diversity, and disparities with the aim of improving outcomes for healthy women and women with breast cancer. The BR Program's work aims to reduce overdiagnosis and overtreatment through individualizing screening and treatment, and derive better outcomes at lower cost. The BR Program achieves its goals through four themes: Theme 1: Improving the Understanding of Breast Cancer Etiology in the Context of the Microenvironment Theme 2: Personalizing Screening and Diagnostics to Increase Health Care Value Theme 3: Identifying New Therapeutic Targets for High-risk Disease Theme 4: Augmenting Efficiency of Drug Development through Innovative Trial Design BR Program: Key Metrics Membership (14 departments, 3 schools) 33 Full 18 Associate 15 Cancer-relevant Funding (direct costs as of $14,454,243 05/31/2017) NCI $5,307,970 37% Peer-reviewed $4,630,302 32% Non-peer-reviewed $4,515,971 31% Cancer-relevant Publications (1/2012-7/2017) 636 Inter-programmatic 141 22% Intra-Programmatic 175 28% High-Impact 190 30% Accruals to Clinical Trials (2016) 5293 58 Therapeutic 140 31 Other Interventional 9 4 Non-interventional 5144 22