A comparative population genomic approach for high-resolution inference of natural selection in fruit flies
用于果蝇自然选择高分辨率推断的比较群体基因组方法
基本信息
- 批准号:10229346
- 负责人:
- 金额:$ 6.64万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-07-20 至 2022-07-19
- 项目状态:已结题
- 来源:
- 关键词:AddressBar CodesBase PairingBiologicalBiological ModelsBiological ProcessBiologyCommunitiesComplementDNA ResequencingDataData SetDemographyDrosophila genusDrosophilidaeElementsEventEvolutionFamilyFellowshipFoundationsFutureGenesGenetic PolymorphismGenetic VariationGenomeGenomic SegmentGenomic approachGenomicsGoalsHybridsIndividualLeadLeadershipLogisticsMapsMeasuresMethodsModelingModernizationNational Research Service AwardsNatural SelectionsOrganismPatternPhenotypePopulationPopulation GeneticsPositioning AttributePostdoctoral FellowProcessRadiationResearchResearch PersonnelResearch ProposalsResolutionResourcesSamplingSecureSignal TransductionSiteSubgroupTestingTimeTrainingVariantWorkbasecomparativecomparative genomicscostdensitydesignempoweredexperienceexperimental studyflygenomic datagenomic toolsimprovednovel strategiespesticide resistanceresponsesimulationskillstool
项目摘要
Project Summary/Abstract
The number of sequenced organisms continues to grow exponentially, providing evolutionary biologists with an
unprecedented resolution for mapping natural selection in the genome. Comparative genomic methods identify
function by searching for genomic elements that are constrained by natural selection. Modern comparative
datasets are saturated with substitutions accumulated over many millions of years of evolution, allowing
functional elements to be identified at the resolution of a few base pairs. Since comparative methods rely on
sequence conservation as evidence of natural selection, substitutions caused by fluctuations in the strength of
selection or rare adaptive events can be mistaken for a lack of function. Population genomic data are robust to
these issues and are the best way to measure constraint in principle, but suffer from low per-site densities,
limiting the resolution at which function can be studied. Here, we propose a comparative population genomics
approach for addressing these limitations by combining polymorphism data across multiple species.
Specifically, we will create an unprecedented dataset of genome assemblies of and population polymorphism
data of up to 100 individuals from each of 100 species from the model system of fruit flies (family
Drosophilidae). In Aim 1, we will map selective constraint at the resolution of less than 3 base pairs and use
these maps to test how constraint evolves across a clade. In Aim 2, we will develop new a test for adaptive
evolution that jointly utilizes substitution and polymorphism data from multiple species and test whether the
same genes are utilized by adaptation in drosophilids. Successful completion of the project will contribute
significantly to the emerging field of comparative population genomics by providing an important publicly
available genomic dataset for the scientific community, new ways to design and analyze large sequencing
experiments, and test fundamental assumptions about the relationship between evolution in populations and
evolution over macro-evolutionary time scales.
The primary goal of this NRSA F32 fellowship is to prepare me with the scientific and professional
foundation to become a leader in the new field of comparative population genomics as an independent
researcher. My long-term scientific goal is to lead an independent research group that utilizes comparative
genomics and population genetics tools to bridge micro and macroevolutionary processes. As a postdoctoral
fellow in the Petrov Lab at Stanford, I will receive new scientific training in wet lab skills, designing sequencing
experiments, and comparative genomics tools by generating and analyzing a genomic dataset that will be the
first of its kind. I will receive substantial training in professional leadership and network building by leading the
effort to build this large genomic resource for the scientific community.
项目总结/文摘
项目成果
期刊论文数量(7)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Evolution and development of male-specific leg brushes in Drosophilidae.
- DOI:10.1007/s00427-022-00694-3
- 发表时间:2022-12
- 期刊:
- 影响因子:2.4
- 作者:Tanaka, Kohtaro;Barmina, Olga;Thompson, Ammon;Massey, Jonathan H.;Kim, Bernard Y.;Suvorov, Anton;Kopp, Artyom
- 通讯作者:Kopp, Artyom
Highly contiguous assemblies of 101 drosophilid genomes.
- DOI:10.7554/elife.66405
- 发表时间:2021-07-19
- 期刊:
- 影响因子:7.7
- 作者:Kim BY;Wang JR;Miller DE;Barmina O;Delaney E;Thompson A;Comeault AA;Peede D;D'Agostino ERR;Pelaez J;Aguilar JM;Haji D;Matsunaga T;Armstrong EE;Zych M;Ogawa Y;Stamenković-Radak M;Jelić M;Veselinović MS;Tanasković M;Erić P;Gao JJ;Katoh TK;Toda MJ;Watabe H;Watada M;Davis JS;Moyle LC;Manoli G;Bertolini E;Košťál V;Hawley RS;Takahashi A;Jones CD;Price DK;Whiteman N;Kopp A;Matute DR;Petrov DA
- 通讯作者:Petrov DA
MaLAdapt Reveals Novel Targets of Adaptive Introgression From Neanderthals and Denisovans in Worldwide Human Populations.
- DOI:10.1093/molbev/msad001
- 发表时间:2023-01-04
- 期刊:
- 影响因子:10.7
- 作者:Zhang, Xinjun;Kim, Bernard;Singh, Armaan;Sankararaman, Sriram;Durvasula, Arun;Lohmueller, Kirk E.
- 通讯作者:Lohmueller, Kirk E.
Widespread introgression across a phylogeny of 155 Drosophila genomes.
- DOI:10.1016/j.cub.2021.10.052
- 发表时间:2022-01-10
- 期刊:
- 影响因子:0
- 作者:Suvorov A;Kim BY;Wang J;Armstrong EE;Peede D;D'Agostino ERR;Price DK;Waddell P;Lang M;Courtier-Orgogozo V;David JR;Petrov D;Matute DR;Schrider DR;Comeault AA
- 通讯作者:Comeault AA
Predictability and parallelism in the contemporary evolution of hybrid genomes.
- DOI:10.1371/journal.pgen.1009914
- 发表时间:2022-01
- 期刊:
- 影响因子:4.5
- 作者:Langdon QK;Powell DL;Kim B;Banerjee SM;Payne C;Dodge TO;Moran B;Fascinetto-Zago P;Schumer M
- 通讯作者:Schumer M
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Bernard Youngsoo Kim其他文献
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{{ truncateString('Bernard Youngsoo Kim', 18)}}的其他基金
A comparative population genomic approach for high-resolution inference of natural selection in fruit flies
用于果蝇自然选择高分辨率推断的比较群体基因组方法
- 批准号:
10066688 - 财政年份:2020
- 资助金额:
$ 6.64万 - 项目类别:














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