Identifying and Targeting Physiological Assays of Circuit Engagement to Improve Impulsivity
识别和针对回路参与的生理分析以改善冲动
基本信息
- 批准号:10297334
- 负责人:
- 金额:$ 35.88万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-07-01 至 2026-04-30
- 项目状态:未结题
- 来源:
- 关键词:AffectAlcohol dependenceAnimalsAttention deficit hyperactivity disorderBehaviorBehavioralBehavioral inhibitionBiological AssayBipolar DisorderBrainBrain regionCategoriesCitalopramClinical PharmacologyCorpus striatum structureCuesDataDevelopmentDiagnosticDimensionsDiseaseDopamineDoseDrug AddictionDrug usageElectroencephalographyElectrophysiology (science)EnvironmentEvaluationFrequenciesFrontotemporal DementiaGoalsGrantHigh Frequency OscillationHumanImpairmentImpulsivityLearningLinkMeasurableMeasuresMedialMental DepressionMental disordersModelingMood DisordersMotorMotor CortexNeurotransmittersObsessive compulsive behaviorPerformancePharmaceutical PreparationsPharmacologyPharmacology StudyPhasePhysiologic MonitoringPhysiologicalPhysiological ProcessesPhysiologyPrefrontal CortexProbabilityProcessReflex actionResearchReversal LearningRewardsRitalinSerotoninSubstance abuse problemSystemTestingThinkingTraumatic Brain InjuryVentral StriatumVisualactivity markerautism spectrum disorderbasebehavior changebehavioral constructbehavioral pharmacologycell typedesigndiscountingdopaminergic neurondosagedrug testingflexibilityimprovednervous system disorderneurophysiologyoptogeneticspre-clinicalresponsesubstance usesuicidaltargeted agenttherapeutic developmenttooltranslation to humans
项目摘要
Project Summary
Behavioral inhibition includes our ability to inhibit prepotent, reflexive or perseverative behaviors in the pursuit
of longer-term goals. Impairments in behavioral inhibition are associated with greater levels of impulsivity.
Impulsivity can be classified into at three major categories. Motor impulsivity is measured using tasks focused
on waiting – impulsive subjects cannot wait as long prior to responding. Impulsivity can also be related to
choice – for example, choosing a smaller immediate reward instead of a larger delayed reward. Finally,
impulsive subjects tend to perseverate (i.e. act without thinking), and thus cannot flexibly shift behaviors as
needed when the environment changes. Impulsivity is pan-diagnostic, occurring in attention deficit hyperactivity
disorder (ADHD), drug & alcohol addiction, affective disorders and even neurologic disorders like
frontotemporal dementia.
Various behavioral tasks have been designed to measure the above features of impulsivity. Such models have
been used to test the effects of drugs on minimizing impulsivity. Drugs used in these tasks can modulate
behavior, but not always in a predictable or even replicable manner across labs, strains or species. This has
precluded simple attempts at testing how pharmacologic agents can improve impulsivity. This grant, following
RFA specifications, is focused on assessing whether electrophysiological measures of impulsivity can provide
a more stable “intermediary” measure of circuit activity relevant to impulsivity that can be used for preclinical
pharmacologic testing and development.
The goals of this grant are first to identify neurophysiological (LFP-based) markers of subdomains of
impulsivity described above, with a particular focus on identifying physiological markers that are translationally
relevant and potentially measurable non-invasively in humans. Next, we will assess whether these physiologic
measures can be used as an assay for therapeutic development by testing how the identified physiological
marker changes in response to varying dosages of drugs known to affect specific subdomains of impulsivity.
Finally, using optogenetics targeted at serotonin or dopamine, we will be able to directly test whether
modulation of these neurotransmitter systems in a temporally refined way affects physiology and behavior.
项目总结
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Dhakshin Ramanathan其他文献
Dhakshin Ramanathan的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Dhakshin Ramanathan', 18)}}的其他基金
Identifying and Targeting Physiological Assays of Circuit Engagement to Improve Impulsivity
识别和针对回路参与的生理分析以改善冲动
- 批准号:
10442567 - 财政年份:2021
- 资助金额:
$ 35.88万 - 项目类别:
Enhancing Neural Circuit Plasticity to Promote Recovery After TBI
增强神经回路可塑性以促进 TBI 后的恢复
- 批准号:
9980179 - 财政年份:2016
- 资助金额:
$ 35.88万 - 项目类别:
相似海外基金
Role of glucocorticoid receptor-mediated mRNA decay in alcohol dependence
糖皮质激素受体介导的 mRNA 衰减在酒精依赖中的作用
- 批准号:
10811212 - 财政年份:2023
- 资助金额:
$ 35.88万 - 项目类别:
6/11 Astrocyte-specific changes and interventions in alcohol dependence
6/11 星形胶质细胞特异性变化和酒精依赖干预
- 批准号:
10591606 - 财政年份:2022
- 资助金额:
$ 35.88万 - 项目类别:
An Investigation of Reward Processing in Co-occurring Alcohol Dependence and Loss of Control Eating
对同时发生的酒精依赖和饮食失控的奖励处理的研究
- 批准号:
486597 - 财政年份:2022
- 资助金额:
$ 35.88万 - 项目类别:
Studentship Programs
Identifying new targets for the treatment of alcohol dependence and relapse: epigenetic analysis of the abstinent brain
确定治疗酒精依赖和复发的新靶点:戒酒大脑的表观遗传学分析
- 批准号:
10396660 - 财政年份:2022
- 资助金额:
$ 35.88万 - 项目类别:
Identifying new targets for the treatment of alcohol dependence and relapse: epigenetic analysis of the abstinent brain
确定治疗酒精依赖和复发的新靶点:戒酒大脑的表观遗传学分析
- 批准号:
10553449 - 财政年份:2022
- 资助金额:
$ 35.88万 - 项目类别:
6/11 Astrocyte-specific changes and interventions in alcohol dependence
6/11 星形胶质细胞特异性变化和酒精依赖干预
- 批准号:
10409263 - 财政年份:2022
- 资助金额:
$ 35.88万 - 项目类别:
Novel GLT-1 activators for the treatment of alcohol dependence: preclinical studies
用于治疗酒精依赖的新型 GLT-1 激活剂:临床前研究
- 批准号:
10517529 - 财政年份:2022
- 资助金额:
$ 35.88万 - 项目类别:
Reducing alcohol-seeking behavior in a rat model of alcohol dependence
减少酒精依赖大鼠模型的寻酒行为
- 批准号:
10684236 - 财政年份:2022
- 资助金额:
$ 35.88万 - 项目类别:
Opposing Contributions of Oxytocin and Corticotropin-Release Factor to Alcohol Dependence
催产素和促肾上腺皮质激素释放因子对酒精依赖的相反作用
- 批准号:
10451814 - 财政年份:2021
- 资助金额:
$ 35.88万 - 项目类别:
Opposing Contributions of Oxytocin and Corticotropin-Release Factor to Alcohol Dependence
催产素和促肾上腺皮质激素释放因子对酒精依赖的相反作用
- 批准号:
10655413 - 财政年份:2021
- 资助金额:
$ 35.88万 - 项目类别: