Capsular serotype in group B Streptococcus colonization and disease
B 组链球菌定植和疾病中的荚膜血清型
基本信息
- 批准号:10297242
- 负责人:
- 金额:$ 71.02万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-06-08 至 2026-05-31
- 项目状态:未结题
- 来源:
- 关键词:AddressAdultAllelesAnimal ModelAntibioticsBacterial GenesBiological AssayBiologyCenters for Disease Control and Prevention (U.S.)CharacteristicsClinicalConjugate VaccinesDataDiseaseEpidemiologyEtiologyFrequenciesGenesGeneticGenomeGenomicsGoalsHumanInfantInfectionLaboratoriesMetadataMorbidity - disease rateMutationNeonatalNewborn InfantPathogenesisPathogenicityPolysaccharidesPopulationPregnant WomenPrevalencePreventionProphylactic treatmentProspective StudiesResearchResearch DesignRiskRisk FactorsRoleSamplingSerotypingStreptococcal InfectionsStreptococcus Group BSystemTechniquesTestingVaccinationVaccinesantimicrobialbacterial geneticsbasecapsulecomparativecostepidemiology studyfitnessgenome sequencinggenomic locusin vivointrapartummortalitymouse modelmutantneonatal sepsisprogramsscreeningscreening programsuccesstoolvaccine candidatevaccine developmentwhole genome
项目摘要
Despite ongoing surveillance and control efforts, group B Streptococcus (GBS) remains an
important cause of infectious morbidity and mortality among newborns, as well as an increasing
cause of invasive disease in adults. GBS vaccine development is a high priority, and a
candidate conjugate polysaccharide vaccine is currently in human trials. This vaccine targets six
of the ten known GBS serotypes, based on epidemiologic studies of invasive disease as well as
rectovaginal carriage. Serotype distribution data are largely based on assays of single colonies
from clinical samples. Based on our preliminary data, we hypothesize that carriage of non-
vaccine type (NVT) GBS (serotypes VI-IX) is substantially more common than previously
realized. Additionally, invasive infections due to NVT GBS are increasing in frequency. It is not
known whether the less common GBS serotypes are intrinsically less fit than the more common
ones with respect to colonization efficiency or pathogenicity. Likewise, the importance of
recently characterized naturally occurring "capsule switch" GBS strains, in which the genetic
locus that determines capsular type has transferred from one strain to another, remains
incompletely understood. Here we propose a program of research designed to test hypotheses
regarding the prevalence of (and risk factors for) colonization and invasive infection due to NVT
GBS serotypes in human samples and to use newly developed techniques for GBS genome
manipulation to understand the role of specific capsule and non-capsule factors in colonization
fitness and pathogenesis in vivo.
尽管正在进行监测和控制工作,B组链球菌(GBS)仍然是一个流行病。
这是新生儿感染发病率和死亡率的重要原因,
成人侵袭性疾病的原因。GBS疫苗开发是一个高度优先事项,
候选的结合多糖疫苗目前正在人体试验中。该疫苗针对6个
在10种已知的GBS血清型中,基于侵袭性疾病的流行病学研究以及
直肠阴道分娩血清型分布数据主要基于单菌落的测定
从临床样本中。根据我们的初步数据,我们假设携带非-
疫苗型(NVT)GBS(血清型VI-IX)比以前更常见
实现了此外,由于NVT GBS引起的侵袭性感染的频率正在增加。不
已知较不常见的GBS血清型是否本质上不如较常见的GBS血清型适合
关于定殖效率或致病性。同样,
最近表征的天然存在的“胶囊开关”GBS菌株,其中遗传
决定荚膜类型的基因座从一个菌株转移到另一个菌株,
不完全理解。在这里,我们提出了一个研究计划,旨在测试假设
关于NVT引起的定植和侵袭性感染的患病率(和风险因素)
GBS血清型检测和GBS基因组检测的新技术
操作以了解特定包膜和非包膜因子在定植中的作用
适应性和致病性。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Adam Jonathan Ratner其他文献
Adam Jonathan Ratner的其他文献
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{{ truncateString('Adam Jonathan Ratner', 18)}}的其他基金
Capsular serotype in group B Streptococcus colonization and disease
B 组链球菌定植和疾病中的荚膜血清型
- 批准号:
10620312 - 财政年份:2021
- 资助金额:
$ 71.02万 - 项目类别:
Capsular serotype in group B Streptococcus colonization and disease
B 组链球菌定植和疾病中的荚膜血清型
- 批准号:
10424581 - 财政年份:2021
- 资助金额:
$ 71.02万 - 项目类别:
Spatiotemporal analysis of gene regulatory programs associated with GBS infection during pregnancy
妊娠期GBS感染相关基因调控程序的时空分析
- 批准号:
10509389 - 财政年份:2018
- 资助金额:
$ 71.02万 - 项目类别:
Spatiotemporal analysis of gene regulatory programs associated with GBS infection during pregnancy
妊娠期GBS感染相关基因调控程序的时空分析
- 批准号:
10053319 - 财政年份:2018
- 资助金额:
$ 71.02万 - 项目类别:
Spatiotemporal analysis of gene regulatory programs associated with GBS infection during pregnancy
妊娠期GBS感染相关基因调控程序的时空分析
- 批准号:
10290310 - 财政年份:2018
- 资助金额:
$ 71.02万 - 项目类别:
DNase For Prevention Of Reproductive Tract Infections In Pregnancy
DNase 用于预防妊娠期生殖道感染
- 批准号:
9265222 - 财政年份:2016
- 资助金额:
$ 71.02万 - 项目类别:
DNase For Prevention Of Reproductive Tract Infections In Pregnancy
DNase 用于预防妊娠期生殖道感染
- 批准号:
8843772 - 财政年份:2014
- 资助金额:
$ 71.02万 - 项目类别:
DNase For Prevention Of Reproductive Tract Infections In Pregnancy
DNase 用于预防妊娠期生殖道感染
- 批准号:
8812495 - 财政年份:2014
- 资助金额:
$ 71.02万 - 项目类别:
DNase For Prevention Of Reproductive Tract Infections In Pregnancy
DNase 用于预防妊娠期生殖道感染
- 批准号:
8265110 - 财政年份:2012
- 资助金额:
$ 71.02万 - 项目类别:
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