Leadership Administrative Core

领导行政核心(LAC)的作用是整合和统一多个跨学科的 布里根妇女医院/哈佛医学院(布里格姆/哈佛)中心的组成部分 用于生殖衰老健康结局的压力和神经调节。布里格姆/哈佛分数 Lac将为我们的SCORE项目、职业提升提供科学、行政和财政监督 核心，和睡眠资源核心，并将催化妇女健康和性方面的进步和创新- 跨Brigham/哈佛分数环境的差异研究。LAC将由Hadine共同领导 Joffe，医学博士和JoAnn Manson，医学博士，担任执行董事和科学顾问， 分别为康纳斯妇女健康中心和性别生物学中心。康纳斯中心是 布里格姆妇女医院(BWH)和哈佛医学院领先的妇女健康研究中心 学校(HMS)，负责协调跨学科和跨部门的妇女健康和性- 分歧调查。Joffe博士和Manson博士都是国际公认的妇女健康领域的领导者， 是长期的合作者，他们的互补科学专长涵盖生殖老龄化健康 这项建议强调的结果：血管运动症状(VMS)、睡眠障碍、心脏代谢、 绝经过渡的认知和其他特征可能影响痴呆的易感性 年迈的女性。这一提议的一个优点是它建立并扩展了研究的重点、领导 调查人员的跨学科合作和职业提升计划，这些都是 康纳斯中心。拉丁美洲和加勒比地区将从现有的合作中利用丰富的资源，并在科学上 BWH和HMS的统一妇女健康计划，特别是那些专注于性别差异、睡眠、 女性的心脏代谢和大脑健康，包括痴呆症。通过利用强大的基础设施 康纳斯中心以及BWH和HMS的其他研究计划和倡议，我们预计会迅速 并无缝启动和实施我们中心的科学和方案活动。戒备森严 关键的外部和内部咨询委员会、专家科学小组和指导委员会的指导 委员会，布里格姆/哈佛分数LAC将提供动态的科学和行政监督， 内部协调，以及与更广泛的SCORE研究联盟的外部接触，这是 生产力的蓬勃发展，导致了一个关于妇女健康和性别差异的全面整合的翻译计划 研究。

The role of the Leadership Administrative Core (LAC) is to integrate and unify the multiple, interdisciplinary components of the Brigham and Women’s Hospital/Harvard Medical School (Brigham/Harvard) Center for Stress and Neural Regulation of Reproductive Aging Health Outcomes. The Brigham/Harvard SCORE LAC will provide scientific, administrative, and fiscal oversight of our SCORE Projects, Career Enhancement Core, and Sleep Resource Core, and will catalyze progress and innovation in women’s health and sex- differences research across the Brigham/Harvard SCORE environment. The LAC will be co-led by Hadine Joffe, MD, MSc, and JoAnn Manson, MD, DrPH, who serve as Executive Director and Scientific Advisor, respectively, for the Connors Center for Women’s Health and Gender Biology. The Connors Center is the leading women’s health research center at Brigham and Women’s Hospital (BWH) and Harvard Medical School (HMS), responsible for coordinating interdisciplinary and cross-departmental women’s health and sex- differences investigation. Drs. Joffe and Manson, both internationally recognized leaders in women’s health, are long-time collaborators whose complementary scientific expertise covers the reproductive aging health outcomes highlighted in this proposal: vasomotor symptoms (VMS), sleep disturbance, cardiometabolic, cognitive, and other characteristics of the menopause transition that may influence dementia susceptibility in aging women. A strength of this proposal is that it builds on and expands the research focus, lead investigators’ interdisciplinary collaborations, and career enhancement programs that are foundational to the Connors Center. The LAC will draw upon the wealth of resources from existing collaborations and scientifically aligned women’s health programs at BWH and HMS, specifically those focused on sex differences, sleep, cardiometabolism, and brain health, including dementia, in women. By leveraging both the robust infrastructure of the Connors Center and that of other BWH and HMS research programs and initiatives, we expect a rapid and seamless initiation and implementation of our Center’s scientific and programmatic activities. Fortified by the guidance of key External and Internal Advisory Boards, an Expert Scientific Panel and a Steering Committee, the Brigham/Harvard SCORE LAC will provide dynamic scientific and administrative oversight, internal coordination, and external engagement with the broader SCORE research consortium necessary for productivity to flourish, leading to a fully-integrated, translational program of women’s health and sex-difference research.