Leadership Administrative Core

领导行政核心

• 批准号: 10893871
• 负责人: HADINE JOFFE
• 金额: $ 22.4万
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-06-01 至 2025-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10893871
• 关键词: Aging; Award; Biological; Biology; Cardiovascular system; Characteristics; Cognitive; Cognitive aging; Collaborations; Communication; Communities; Dementia; Ensure; Environment; Fostering; Future; Gender; Goals; Growth; Health; Hospitals; Infrastructure; Institution; International; Investigation; Lead; Leadership; Medicine; Monitor; Neurosciences; Outcome; Performance; Perimenopause; Pilot Projects; Policies; Predisposition; Productivity; Research; Research Personnel; Research Project Grants; Resource Sharing; Resources; Role; Sex Differences; Site; Sleep; Sleep disturbances; Stress; Time; Translating; Translational Research; Travel; United States National Institutes of Health; Woman; Women' s Health; brain health; cardiometabolism; career; dementia risk; fortification; health difference; innovation; interdisciplinary collaboration; medical schools; neuroregulation; policy implication; programs; reproductive senescence; sex; symposium; synergism; translational potential; translational therapeutics; vasomotor symptoms

The role of the Leadership Administrative Core (LAC) is to integrate and unify the multiple, interdisciplinary components of the Brigham and Women’s Hospital/Harvard Medical School (Brigham/Harvard) Center for Stress and Neural Regulation of Reproductive Aging Health Outcomes. The Brigham/Harvard SCORE LAC will provide scientific, administrative, and fiscal oversight of our SCORE Projects, Career Enhancement Core, and Sleep Resource Core, and will catalyze progress and innovation in women’s health and sex- differences research across the Brigham/Harvard SCORE environment. The LAC will be co-led by Hadine Joffe, MD, MSc, and JoAnn Manson, MD, DrPH, who serve as Executive Director and Scientific Advisor, respectively, for the Connors Center for Women’s Health and Gender Biology. The Connors Center is the leading women’s health research center at Brigham and Women’s Hospital (BWH) and Harvard Medical School (HMS), responsible for coordinating interdisciplinary and cross-departmental women’s health and sex- differences investigation. Drs. Joffe and Manson, both internationally recognized leaders in women’s health, are long-time collaborators whose complementary scientific expertise covers the reproductive aging health outcomes highlighted in this proposal: vasomotor symptoms (VMS), sleep disturbance, cardiometabolic, cognitive, and other characteristics of the menopause transition that may influence dementia susceptibility in aging women. A strength of this proposal is that it builds on and expands the research focus, lead investigators’ interdisciplinary collaborations, and career enhancement programs that are foundational to the Connors Center. The LAC will draw upon the wealth of resources from existing collaborations and scientifically aligned women’s health programs at BWH and HMS, specifically those focused on sex differences, sleep, cardiometabolism, and brain health, including dementia, in women. By leveraging both the robust infrastructure of the Connors Center and that of other BWH and HMS research programs and initiatives, we expect a rapid and seamless initiation and implementation of our Center’s scientific and programmatic activities. Fortified by the guidance of key External and Internal Advisory Boards, an Expert Scientific Panel and a Steering Committee, the Brigham/Harvard SCORE LAC will provide dynamic scientific and administrative oversight, internal coordination, and external engagement with the broader SCORE research consortium necessary for productivity to flourish, leading to a fully-integrated, translational program of women’s health and sex-difference research.

领导行政核心（LAC）的作用是整合和统一多个跨学科的 布里格姆妇女医院/哈佛医学院（布里格姆/哈佛）中心的组成部分 压力和生殖衰老健康结果的神经调节。布里格姆/哈佛分数 LAC将为我们的SCORE项目提供科学，行政和财政监督，职业提升 核心和睡眠资源核心，并将催化妇女的健康和性的进步和创新- 跨布里格姆/哈佛SCORE环境的差异研究。LAC将由Hadine共同领导 Joffe，MD，MSc和JoAnn曼森，MD，DrPH，担任执行董事和科学顾问， 康纳斯妇女健康和性别生物学中心。康纳斯中心是 布里格姆妇女医院（BWH）和哈佛医学院的领先妇女健康研究中心 学校（HMS），负责协调跨学科和跨部门的妇女健康和性- 差异调查。Joffe博士和曼森博士都是国际公认的妇女健康领域的领导者， 是长期合作者，其互补的科学专业知识涵盖生殖老化健康 本提案中强调的结果：血管紧张症状（VMS），睡眠障碍，心脏代谢， 认知和其他可能影响老年痴呆症易感性的更年期特征， 老年妇女这项建议的优点是，它建立在并扩大了研究重点， 研究人员的跨学科合作，以及职业提升计划，这是基础， 康纳斯中心拉丁美洲和加勒比地区将利用现有合作的丰富资源， 在BWH和HMS调整妇女健康计划，特别是那些专注于性别差异，睡眠， 心脏代谢和大脑健康，包括痴呆症。通过利用强大的基础架构 康纳斯中心和其他BWH和HMS研究计划和倡议，我们期待一个快速的 无缝启动和实施我们中心的科学和计划活动。加强了 主要外部和内部咨询委员会、专家科学小组和指导委员会的指导 委员会，布里格姆/哈佛SCORE LAC将提供动态的科学和行政监督， 内部协调，以及与更广泛的SCORE研究联盟的外部接触， 生产力蓬勃发展，导致妇女健康和性别差异的全面整合，转化方案 research.