Pathology and Biochemistry Core

病理学和生物化学核心

基本信息

  • 批准号:
    10424902
  • 负责人:
  • 金额:
    $ 28.83万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2017
  • 资助国家:
    美国
  • 起止时间:
    2017-05-01 至 2027-04-30
  • 项目状态:
    未结题

项目摘要

PROJECT SUMMARY: CORE B Accumulation of inflammatory macrophages as well as innate and adaptative immune cells is a common feature of cardiometabolic diseases, including atherosclerosis, obesity and non-alcoholic fatty liver diseases. Inflammation in metabolic tissues accelerates atherosclerosis and metabolic dysfunction. The ability to examine changes in gene expression in immune cells, particularly macrophage populations, in the plaque, adipose tissue depots, and liver during cardiometabolic disease provides insights into that key pathways that promote or inhibit the inflammatory response and their corresponding effects on pathologic processes in these tissues. As such, a Core will be established to: 1) isolate and quantify macrophage and other immune cell subsets from atherosclerotic plaque, adipose tissue and liver by FACS; 2) monitor changes in metabolic parameters within the systemic circulation, atherosclerotic plaque, adipose tissue and liver; and 3) perform sectioning and histologic quantification of atherosclerotic plaques, fat depots and liver morphology. These procedures are key to the successful execution of the Aims of all three projects in this Program Project, and centralizing the immunohistochemical and biochemical assays will ensure consistency and reproducibility, which in turn will maximize the efficiency and productivity of the scientists within each project.
项目总结:核心b

项目成果

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专利数量(0)

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KATHRYN J MOORE其他文献

KATHRYN J MOORE的其他文献

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{{ truncateString('KATHRYN J MOORE', 18)}}的其他基金

Pathology and Biochemistry Core
病理学和生物化学核心
  • 批准号:
    10616530
  • 财政年份:
    2017
  • 资助金额:
    $ 28.83万
  • 项目类别:
Netrin-1 in Metabolic and Inflammatory Crosstalk in Cardiometabolic Disease
Netrin-1 在心脏代谢疾病代谢和炎症串扰中的作用
  • 批准号:
    10424905
  • 财政年份:
    2017
  • 资助金额:
    $ 28.83万
  • 项目类别:
Non-coding RNA regulation of cholesterol homeostasis and atherosclerosis
非编码RNA对胆固醇稳态和动脉粥样硬化的调节
  • 批准号:
    10570209
  • 财政年份:
    2017
  • 资助金额:
    $ 28.83万
  • 项目类别:
Non-coding RNA regulation of cholesterol homeostasis and atherosclerosis
非编码RNA对胆固醇稳态和动脉粥样硬化的调节
  • 批准号:
    10350668
  • 财政年份:
    2017
  • 资助金额:
    $ 28.83万
  • 项目类别:
Netrin-1 in Metabolic and Inflammatory Crosstalk in Cardiometabolic Disease
Netrin-1 在心脏代谢疾病代谢和炎症串扰中的作用
  • 批准号:
    10616543
  • 财政年份:
    2017
  • 资助金额:
    $ 28.83万
  • 项目类别:
Macrophage Trafficking, Inflammation & Metabolism in Obesity: Role of Guidance Cue Molecules
巨噬细胞贩运、炎症
  • 批准号:
    9196307
  • 财政年份:
    2016
  • 资助金额:
    $ 28.83万
  • 项目类别:
miR-33 Pathway Inhibition for Improving HDL Functionality
抑制 miR-33 通路以改善 HDL 功能
  • 批准号:
    8987982
  • 财政年份:
    2015
  • 资助金额:
    $ 28.83万
  • 项目类别:
miR-33 Pathway Inhibition for Improving HDL Functionality
抑制 miR-33 通路以改善 HDL 功能
  • 批准号:
    9265503
  • 财政年份:
    2015
  • 资助金额:
    $ 28.83万
  • 项目类别:
miR-33 Pathway Inhibition for Improving HDL Functionality
抑制 miR-33 通路以改善 HDL 功能
  • 批准号:
    9109685
  • 财政年份:
    2015
  • 资助金额:
    $ 28.83万
  • 项目类别:
Mechanisms of CD36 Signal Transduction - Resubmission - 1
CD36 信号转导机制 - 重新提交 - 1
  • 批准号:
    8968853
  • 财政年份:
    2013
  • 资助金额:
    $ 28.83万
  • 项目类别:

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