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Positronium lifetime imaging using TOF PET

使用 TOF PET 进行正电子寿命成像

基本信息

批准号：
10443873
负责人：
JINYI QI
金额：
$ 19.63万
依托单位：
UNIVERSITY OF CALIFORNIA AT DAVIS
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-07-02 至 2024-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10443873
关键词：
Address Applications Grants Biochemical Cardiology Cardiovascular Diseases Clinic Computer Simulation Diagnostic Neoplasm Staging Dimensions Dreams Effectiveness Electrons Future Human Development Human body Hydrogen Peroxide Hydroxyl Radical Hypoxia Image Imaging Phantoms Imaging Techniques Injections Malignant Neoplasms Measurement Measures Medical Imaging Medical center Methods Molecular Neurology Oncology Oxygen Patient-Focused Outcomes Photons Positron Positron-Emission Tomography Property Publishing Radiation therapy Radioactive Tracers Radioisotopes Resolution Sampling Scanning Techniques Technology Time Tissues Tracer Use Effectiveness base cancer therapy chemotherapy detection sensitivity detector effective therapy experimental study fluorescence lifetime imaging human disease human imaging image reconstruction imaging modality improved in vivo in vivo imaging molecular imaging nervous system disorder outcome prediction photon-counting detector pressure radioresistant radiotracer reconstruction simulation standard measure treatment planning tumor tumor hypoxia

项目摘要

Project Summary/Abstract Positron emission tomography (PET) is a high-sensitivity molecular imaging modality widely used in oncology, neurology, and cardiology, with the ability to observe molecular-level activities inside a living body through the injection of specific radioactive tracers with positron emitters. Recently it has been shown that the lifetime of positronium, a metastable state formed by a pair of electron and positron, is sensitive to the microenvironment of the surrounding tissue, such as oxygen pressure. Such information is valuable for cancer staging and treatment planning. However, currently there is no practical method to imaging the positronium lifetime at a spatial resolution matching that of PET due to the limited photon detection sensitivity and lack of proper image reconstruction method. This proposal addresses these problems by developing a statistically based image reconstruction method for positronium lifetime imaging (PLI) and combining it with the newly developed total- body EXPLORER PET scanner at UC Davis. We will demonstrate the effectiveness of the method using phantom experiments on the EXPLORER scanner. The advantage of the PLI is that the lifetime measurement is independent of the tracer concentration and can be used together with standard PET imaging. The combination of PLI and PET will add another dimension to current PET imaging and provide useful information for understanding the microenvironment of the tissue for studying various human diseases.

项目总结/文摘