Hematopoiesis Training Grant

摘要 宾夕法尼亚大学的造血训练补助金成立于1999年，其主要目标是 培养研究生和博士后研究员的职业生涯，作为成功的调查工作的领域， 与造血和血液疾病有关。培养博士后30名，博士后18名 科学家，包括目前正在培训的3名博士后和4名博士前受训人员。这是一个多学科， 跨部门的培训计划，利用宾夕法尼亚大学医学院的广泛资源 （PSOM），费城儿童医院（CHOP）和兽医学院。程序将绘制 博士前候选人从大型和高度重视博士和MD-PhD计划在PSOM和博士后， 来自PSOM和CHOP竞争性血液学和病理学奖学金项目的博士申请人， 以及宾夕法尼亚大学基础科学系的领先实验室。研究导师由30名 所有学术级别的科学多样化培训师，其研究兴趣几乎涵盖所有领域， 造血以及年轻的教师谁带来了尖端技术的血液学研究。的 该计划的学术要素包括课程作业，研讨会，实验室工作， 技能培训、正式和非正式指导和职业咨询、演讲、手稿和赠款 写作，这是有效地结合起来，培养新的调查人员在造血的基础。学员 根据书面和口头陈述，个性化发展计划和状态进行评估 与PI/PD以及研究和计划导师举行会议。这一全面的成功 方法是由100%的毕业率与第一作者论文，大量的博士前 继续从事博士后研究的被任命者，在项目结束后获得资助的人数 毕业，实习生出版物的数量直接相关的T32支持的研究（博士后 校友平均4.3篇同行评议论文和博士前校友3.6篇论文），博士后人数 被任命者已晋升为学术界（56%）和工业界（32%）的领导职位。的 造血计划于二零一七年十二月经历领导层变动。新的PI/PD得到了很好的支持 由经验丰富的监督委员会，包括一个内部咨询委员会（IAB）和一个新的外部 顾问委员会（EAB）。PI、IAB和EAB在首届T32务虚会上进行了全面审查， 建议通过举办年度务虚会，增加学员/导师之间的互动， 每季度举行一次研究研讨会，并为各级人员举办导师培训。审查还确定了一个大型人才库， 高素质的博士前MD-PhD学生在宾夕法尼亚大学与造血的职业兴趣，以及 持续涌入的教师在造血为重点的研究宾夕法尼亚大学/CHOP。因此，该应用程序 要求增加一个职位，专门为这些综合学位的学生和另一个新的博士后 鼓励和支持他们在造血研究方面的职业发展。

ABSTRACT The Hematopoiesis Training Grant at the University of Pennsylvania was founded in 1999 with the primary goal to prepare graduate students and postdoctoral fellows for careers as successful investigators working in areas related to hematopoiesis and blood disorders. The Program has trained 30 post-doctoral and 18 pre-doctoral scientists, including 3 post-doctoral and 4 pre-doctoral trainees currently in training. It is a multi-disciplinary, cross-departmental training program that capitalizes on the extensive resources of the Penn School of Medicine (PSOM), the Children’s Hospital of Philadelphia (CHOP), and School of Veterinary Medicine. The Program draws pre-doctoral candidates from the large and highly regarded PhD and MD-PhD programs at the PSOM and post- doctoral applicants from the competitive hematology and pathology fellowship programs at PSOM and CHOP, and from leading laboratories in the basic science departments at Penn. Research mentorship is provided by 30 scientifically diverse trainers of all academic ranks with research interests that encompass virtually all areas of hematopoiesis as well as young faculty who bring in cutting-edge technology to hematology research. The academic elements of the Program include an integrated curriculum of coursework, seminars, laboratory work, skills training, formal and informal mentoring and career counseling, presentation, and manuscript and grant writing, which are effectively combined to train new investigators in the fundamentals of hematopoiesis. Trainees are evaluated on the basis of written and oral presentations, Individualized Development Plans, and status conferences with the PI/PD and both research and Program mentors. The success of this comprehensive approach is indicated by the 100% graduation rate with first-author papers, the large numbers of predoctoral appointees continuing in postdoctoral research, the number who have been awarded funding following Program graduation, the number of trainee publications directly related to their T32 supported research (postdoctoral alumni averaged 4.3 peer-reviewed papers and predoctoral alumni 3.6 papers), and the number of postdoctoral appointees who have progressed to leadership positions in academia (56%) and industry (32%). The Hematopoiesis Program underwent a change in leadership in December 2017. The new PI/PD is well supported by the experienced Oversight Committees, including an Internal Advisory Board (IAB) and a new External Advisory Board (EAB). A comprehensive review by the PI, IAB and EAB in the inaugural T32 retreat resulted in the recommendation to increase the interactions among the trainees/mentors by establishing annual retreat and quarterly research seminars and instituting mentor training for all ranks. The review also identified a large pool of highly qualified pre-doctoral MD-PhD students at Penn with career interests in hematopoiesis, as well as a continuous influx of faculty in hematopoiesis-focused research to Penn/CHOP. Consequently, this application requests one additional position that is dedicated to these combined-degree students and another new postdoc position to encourage and support their career progression in hematopoiesis research.