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A Biliary Tract-Specific Fluorescence Image-guided Surgery

胆道特异性荧光图像引导手术

基本信息

批准号：
10323760
负责人：
Richard Jaepyeong Cha
金额：
$ 25.66万
依托单位：
OPTOSURGICAL, LLC
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-09-23 至 2023-09-22
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10323760
关键词：
Adoption Anatomy Animals Bile duct carcinoma Bile fluid Biliary Blood Vessels Cessation of life Child Cholecystectomy Clinical Color Visions Common bile duct structure Complex Custom Cystic duct structure Development Devices Dissection Duct (organ) structure Dyes Endoscopy Engineering Environment Excision Extrahepatic Eye Family suidae Fluorescence Fluorescent Dyes Fostering Future Goals Hand Hemorrhage Hepatectomy Hepatic Hepatobiliary Hospitals Human Image Image-Guided Surgery Imaging Techniques Imaging technology Impairment Incidence Individual Indocyanine Green Intelligence Intrahepatic bile duct Label Laparoscopes Laparoscopic Cholecystectomy Laparoscopy Laser Speckle Imaging Lead Length of Stay Liver Liver neoplasms Liver parenchyma Malignant neoplasm of liver Modeling Morbidity - disease rate Multi-modal optical imaging Operative Surgical Procedures Optics Outcome Palpation Pathway interactions Pediatric Research Perfusion Phase Physiological Physiology Positioning Attribute Primary Malignant Neoplasm of Liver Recovery Research Shapes Short Waves Site Source Structure Surface Surgeon Surgical complication System Technical Expertise Techniques Technology Testing Time Tissues Touch sensation Ultrasonography Validation Vision Visual Visualization Work bile duct biliary tract burden of illness clinical translation fluorescence imaging image guided imager imaging platform imaging system improved improved functioning improved outcome intrahepatic minimally invasive mortality multimodality next generation novel optical imaging porcine model pre-clinical preclinical study research and development robot assistance sensor sensor technology surgery outcome tool

项目摘要

Abstract The primary liver cancer including intrahepatic bile duct cancer pose significant global burden of illness with increasing incidence and mortality in US and around the world. Surgery remains the most effective form of treatment. However, surgical complication rates for medium to high complexity hepatectomies persist in 30-40% range even in highly skilled hands and at high volume centers. The critical challenges appear to be attributable to navigating liver parenchymal dissection, where size of resection surface, associated with blood loss and missed bile leaks from the liver parenchyma, and prolonged operative time during dissection pose significant obstacle. In this research, we propose to develop an upgraded laparoscopic imager for deeper biliary-specific fluorescent imaging using a short-wave infrared (SWIR) sensor and high-definition RGB color vision, and to test the utility of our multimodal laparoscopic imaging technique in liver surgery throughout preclinical swine studies. The clear anatomic display of intrahepatic critical structures and functional physiology will make the hepatic dissection safer and more efficient for any liver resection. The goal of this 1-year research is to develop and evaluate the novel biliary-specific fluorescence and laparoscopic vision/display through the following specific aims; Aim1: To develop a formfactor SWIR camera system for fluorescence image-guided laparoscopy; Aim 2: To validate the usefulness of the developed new vision platform in preclinical animal studies.

摘要