Optimizing spatial sampling strategies for the molecular surveillance of drug resistant malaria
优化耐药疟疾分子监测的空间采样策略
基本信息
- 批准号:10322453
- 负责人:
- 金额:$ 1.09万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-01-16 至 2022-04-30
- 项目状态:已结题
- 来源:
- 关键词:Africa South of the SaharaAnopheles GenusAnti-malarial drug resistanceAntimalarialsArtemisininsArthropodsBehaviorBiteBloodBlood ScreeningBlood specimenBurkina FasoChemopreventionChildClimateClinicClinicalClinical ResearchClinical TreatmentCombined Modality TherapyCommunicationCommunitiesCountryCulicidaeDataDeveloping CountriesDevelopmentDiseaseDrug resistanceEpidemiologistEpidemiologyFeeding behaviorsFellowshipFemaleFutureGenotypeGeographic FactorGeographyGoalsHealthHouseholdHumanIn VitroIndividualInterventionLocationMalariaMalaria preventionMentorsMethodsModelingMolecularMolecular EpidemiologyMonitorMorbidity - disease rateMulti-Drug ResistanceMutationParasite resistanceParasitesPatientsPharmaceutical PreparationsPharmacologyPlasmodiumPlayPoliciesPopulationPrevalencePreventionRegimenResearchResearch PersonnelResearch TrainingResistanceRestRoleSamplingSeasonsSiteSoutheastern AsiaSpatial DistributionSurveysTechniquesTherapeuticTimeUncertaintyVector-transmitted infectious diseasebasecareerdesigndisease transmissionefficacy studyepidemiology studyexperiencefeedingfield studyfitnessglobal healthhuman subjectimprovedmolecular markermortalitymultidisciplinarynovelpressureprospectivepublic databaseresistance mutationscale upstemsuccesssurveillance datasurveillance strategytooltransmission processurban settingvectorvector control
项目摘要
Project Summary/Abstract
Antimalarial drugs are a critical tool in both the treatment and prevention malaria worldwide, yet their success
has been hampered by the continual emergence and spread of antimalarial resistance (AMR). In the current
climate of multidrug resistance, including resistance to the global front-line drug artemisinin, there is a need to
scale up timely and widespread surveillance of AMR. The development of artemisinin resistance in sub-
Saharan Africa would have a devastating impact on malaria-related morbidity and mortality. Molecular
surveillance, which involves the screening of blood samples to determine the prevalence of molecular markers
associated with drug resistance, can be a valuable tool for detecting emergent resistance genotypes before
they become widespread. This proposal will first characterize the state of molecular monitoring efforts across
sub-Saharan Africa. With the hypothesis that studies remain temporally and geographically clustered, we will
use model-based geostatistics to interpolate the prevalence of AMR markers and suggest optimal strategies
for future sampling sites. Next, in Burkina Faso, we will assess the utility of an alternative surveillance tool: the
use of bloodmeals collected by arthropods, a technique known as xenosurveillance, to monitor molecular
markers in humans that have been recently fed upon. We believe xenosurveillance may act as a
complementary, rapidly deployable, and acceptable tool for the molecular surveillance of AMR. Finally,
because molecular surveillance relies primarily on human-based interventional or cross-sectional trials, the role
of the mosquito in transmitting drug resistant parasites remains unexplored. We will leverage our
xenosurveillance samples to investigate the impact of vector behavior on the differential transmission of AMR
parasites.
This project will investigate the prevalence and dynamics of antimalarial resistance at multiple spatial scales.
The goal of the proposed research is to help guide policymakers in their efforts to control the spread of AMR in
sub-Saharan Africa, where drug pressure stems from both treatment and prevention regimens, and this
pharmacological landscape changes regularly alongside the vector control landscape. After the completion of
this two-year research and training fellowship, the applicant will have an advanced skillset in geostatistical
modeling, molecular epidemiology, scientific communication and extensive field experience. Ultimately, the
candidate seeks expertise in spatial analysis and applied epidemiology in order to advance surveillance efforts
and improve our understanding of the geographic factors that influence vector-borne disease transmission. A
multidisciplinary mentoring team will prepare the applicant for research independence in a career as a global
health researcher and vector-borne disease epidemiologist at the nexus of environmental and human health.
项目总结/文摘
项目成果
期刊论文数量(4)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Molecular surveillance of antimalarial partner drug resistance in sub-Saharan Africa: a spatial-temporal evidence mapping study.
- DOI:10.1016/s2666-5247(20)30094-x
- 发表时间:2020-09
- 期刊:
- 影响因子:0
- 作者:Ehrlich HY;Jones J;Parikh S
- 通讯作者:Parikh S
Tracking antimalarial drug resistance using mosquito blood meals: a cross-sectional study.
- DOI:10.1016/s2666-5247(23)00063-0
- 发表时间:2023-06
- 期刊:
- 影响因子:38.2
- 作者:Ehrlich, Hanna Y.;Some, Fabrice;Bazie, Thomas;Ebou, Catherine Neya;Dembele, Estelle Lotio;Balma, Richard;Goodwin, Justin;Wade, Martina;Bei, Amy K.;Ouedraogo, Jean-Bosco;Foy, Brian;Dabire, Roch K.;Parikh, Sunil
- 通讯作者:Parikh, Sunil
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Hanna Ehrlich其他文献
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{{ truncateString('Hanna Ehrlich', 18)}}的其他基金
Optimizing spatial sampling strategies for the molecular surveillance of drug resistant malaria
优化耐药疟疾分子监测的空间采样策略
- 批准号:
9911241 - 财政年份:2020
- 资助金额:
$ 1.09万 - 项目类别: