Task Area A shall encompass annual follow-up of cohort members, clinical events investigations, study operations, and data analysis and manuscript writing. If implemented, Task A.1 will provide fundin

任务领域 A 应包括队列成员的年度随访、临床事件调查、研究操作以及数据分析和稿件撰写。

• 批准号: 10329692
• 负责人: James Pankow
• 金额: $ 64.41万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-12-19 至 2021-12-18
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10329692
• 关键词: Abdomen; Address; Ancillary Study; Ankle; Area; Behavioral; Cardiac; Cardiovascular Diseases; Characteristics; Clinical; Collaborations; Collection; Contracts; Coronary Arteriosclerosis; Data; Data Analyses; Disease; Event; Fostering; Functional disorder; Funding; Goals; Investigation; Laboratories; Magnetic Resonance Imaging; Manuscripts; Measurement; Measures; Mediating; Multi-Ethnic Study of Atherosclerosis; Myocardial; National Heart, Lung, and Blood Institute; Participant; Photography; Policies; Population Heterogeneity; Process; Research Personnel; Retina; Risk Factors; Risk Marker; Sampling; Subgroup; Ultrasonography; United States National Institutes of Health; Woman; Writing; X-Ray Computed Tomography; aged; brachial artery; clinical examination; cohort; follow-up; genetic variant; indexing; interest; member; men; operation; population based; predict clinical outcome; psychologic; radial artery; recruit; response; socioeconomics; tonometry

The Multi-Ethnic Study of Atherosclerosis (MESA) is a study of the correlates, predictors, and progression of subclinical cardiovascular disease (CVD) in a diverse population-based sample of men and women aged 45-84 who had no evidence of clinical CVD at baseline. During the initial funding period of MESA, 6,814 participants were recruited from six Field Centers during 2000-2002 and examined for evidence of subclinical coronary atherosclerosis, using computed tomography, cardiac MRI, carotid ultrasound, flow-mediated brachial artery dilation, radial artery tonometry, ankle-brachial index measurement, and retinal photography. A number of other variables including abdominal aortic CT, carotid MRI, cardiac MRI tagging for measures of regional myocardial function; established and putative laboratory risk markers; socioeconomic, psychological, behavioral and environmental characteristics; and genetic variants were assessed in subsets of the MESA cohort. Examinations of selected components were repeated over five subsequent examinations spanning approximately 16 years and the cohort has been continuously followed for clinical CVD events since the baseline examination. The study will continue to support in-depth ancillary studies that are funded outside of the NHLBI contract. These studies will be operationally integrated into the main study, and the data will be shared across the entire “MESA Suite” of studies, per current MESA and NIH data-sharing policies. The study’s data will be provided to interested investigators through a defined process that encourages maximum data utilization while protecting participant confidentiality.

动脉粥样硬化的多种族研究（MESA）是一项关于动脉粥样硬化的相关因素、预测因素和进展的研究。 亚临床心血管疾病（CVD）在45 - 84岁男性和女性的不同人群样本中 在基线时没有临床CVD的证据。在MESA的初始供资期间，6 814名参与者 在2000 - 2002年期间，从六个现场中心招募了100名患者，并检查了亚临床冠状动脉病变的证据。 动脉粥样硬化，使用计算机断层扫描，心脏MRI，颈动脉超声，血流介导的肱动脉 扩张、桡动脉张力测定、踝肱指数测量和视网膜照相。一些 其他变量包括腹主动脉CT、颈动脉MRI、心脏MRI标记，用于测量区域 心肌功能;既定和推定的实验室风险标志物;社会经济、心理， 行为和环境特征;并在MESA的子集中评估遗传变异 队列。在随后的五次检查中重复检查选定的组件， 自2010年以来，该队列已持续随访临床CVD事件约16年。 基线检查。 该研究将继续支持在NHLBI合同之外资助的深入辅助研究。 这些研究将在操作上集成到主研究中，数据将在整个研究中共享。 "MESA套件"研究，根据当前MESA和NIH数据共享政策。研究数据将提供给 通过定义的流程，鼓励最大限度地利用数据，同时保护 参与者保密。