Promoting Independence with Compensatory Cognitive Rehabilitation: A Pilot Clinical Trial for Early-Stage Alzheimer's Disease

通过补偿性认知康复促进独立：早期阿尔茨海默病的试点临床试验

• 批准号: 10341180
• 负责人: Alyssa Marie Lanzi
• 金额: $ 16.95万
• 依托单位: UNIVERSITY OF DELAWARE
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-02-15 至 2026-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10341180
• 关键词: Active Learning; Address; Adherence; Adult; Alzheimer' s Disease; Award; Behavior; Behavior Therapy; Behavior assessment; Behavioral Model; Bypass; Caring; Clinical; Clinical Trials; Clinical effectiveness; Cognition; Cognitive; Cognitive Therapy; Conduct Clinical Trials; Control Groups; Delaware; Dementia; Development; Development Plans; Discipline; Disease; Dissemination and Implementation; Doctor of Philosophy; Educational process of instructing; Effectiveness; Elderly; Enrollment; Evidence based intervention; Family member; Feedback; Financial compensation; Florida; Focus Groups; Funding; Future; Goals; Health Professional; Independent Living; Individual; Intervention; Intervention Trial; Knowledge; Language; Learning; Life; Literature; Maintenance; Manuals; Memory; Mentors; Mentorship; Modernization; Modification; Neuropsychology; Occupational Therapist; Occupational Therapy; Outcome; Outcome Measure; Participant; Pathologist; Patient Outcomes Assessments; Performance; Persons; Pharmacology; Phase I Clinical Trials; Population; Prevalence; Procedures; Public Health; Quality of life; Randomized; Randomized Controlled Trials; Rehabilitation therapy; Research; Research Activity; Research Assistant; Roter; Self Efficacy; Short-Term Memory; Societies; Specific qualifier value; Speech; Speech-Language Pathology; Structure; System; Training; United States National Institutes of Health; Universities; Work; amnestic mild cognitive impairment; base; behavioral clinical trial; career development; cognitive function; cognitive rehabilitation; cognitive system; cognitive task; cognitive testing; community setting; daily functioning; design; disability; dissemination research; efficacy evaluation; experience; experimental group; implementation research; improved; innovation; learning strategy; mild cognitive impairment; multidisciplinary; person centered; pilot trial; preservation; prevent; professor; programs; psychologic; randomized trial; repaired; research study; restorative treatment; skills; success; therapy development; tool; treatment adherence; treatment comparison; treatment effect; treatment group

ABSTRACT CANDIDATE: Alyssa Lanzi, Ph.D. is an academic speech-language pathologist and Research Assistant Professor at the University of Delaware. In this K23 application, Dr. Lanzi will build on her training and research studying cognitive rehabilitation approaches that preserve independence in adults with mild cognitive impairment (MCI) and early-stage dementia from Alzheimer’s disease (AD). The objective of this award is to acquire new knowledge, skills, and experiences needed to independently conduct clinical trials of these interventions, as well as future dissemination and implementation. Her long-term goal is to establish a productive research program that develops, evaluates, and disseminates cognitive rehabilitation interventions for adults with AD and MCI. CAREER DEVELOPMENT PLAN: Dr. Lanzi proposes to: 1) learn how to design and conduct randomized controlled trials of behavioral interventions for adults with MCI and dementia from AD; 2) receive training in the multidisciplinary assessment of the cognitive, psychological, and independent living skills of this population; 3) acquire knowledge and skills related to dissemination and implementation of behavioral interventions for rehabilitation clinicians. The training plan includes rich experiential learning activities such as multidisciplinary team-based cognitive assessment activities in diverse community settings. ENVIRONMENT: Dr. Lanzi will train with a multidisciplinary team of NIH-funded mentors with expertise in clinical trials research, MCI and dementia from AD, and dissemination/implementation research. Dr. Verdolini Abbott (U Delaware), co-primary mentor, is a senior academic speech-language pathologist and has extensive expertise in clinical trials of behavioral interventions. Dr. Cohen (U Delaware), co-primary mentor, is a rehabilitation-oriented neuropsychologist with a record of multi-disciplinary cognitive assessment research. Dr. Rodakowski (U Pittsburgh), co-mentor, is an academic occupational therapist with expertise in cognitive strategy training and independent living skills for adults with MCI. Dr. Smith (U Florida), co-mentor, is a senior neuropsychologist and renowned expert in MCI, AD, and behavioral intervention approaches. RESEARCH: Most treatment approaches for MCI and dementia from AD have focused on restoring cognitive weaknesses. Unfortunately, these are suboptimal for preserving or improving independent living skills. Aim 1 of the proposed research is to conduct a pilot trial to evaluate the efficacy of the Structured External Memory Aid Treatment, a compensation-based approach for adults with MCI that promotes independent living skills by teaching the use of strategies to compensate for cognitive weaknesses (e.g., note-taking systems). Aim 2 is to evaluate the demographic, clinical, and neuropsychological predictors of treatment adherence. Aim 3 is to refine treatment procedures and materials that will be used to train future interventionists. The completion of these training and research aims are critical for Dr. Lanzi’s career development and continued success in investigating the efficacy and effectiveness of compensatory cognitive interventions that enhance the independence and quality of life of adults with AD.

抽象的 候选人：Alyssa Lanzi，博士是一位学术言语病理学家和研究助理 特拉华大学教授。在这个 K23 应用程序中，兰子博士将在她的培训和研究的基础上 研究保持轻度认知障碍成年人独立性的认知康复方法 （MCI）和阿尔茨海默病（AD）引起的早期痴呆。该奖项的目的是获得新的 独立进行这些干预措施的临床试验所需的知识、技能和经验，以及 作为今后的传播和实施。她的长期目标是建立一个富有成效的研究计划 该组织开发、评估和传播针对 AD 和 MCI 成人的认知康复干预措施。 职业发展规划：兰子博士建议：1）学习如何设计和进行随机化 对患有 MCI 和 AD 痴呆的成人进行行为干预的对照试验； 2）接受以下方面的培训 对该人群的认知、心理和独立生活技能进行多学科评估； 3） 获得与传播和实施行为干预措施相关的知识和技能 康复临床医生。培训计划包括丰富的体验式学习活动，例如多学科 在不同的社区环境中进行基于团队的认知评估活动。环境：兰子博士将进行训练 拥有由 NIH 资助的多学科导师团队，他们在临床试验研究、MCI 和痴呆症方面拥有专业知识 来自 AD 和传播/实施研究。 Verdolini Abbott 博士（特拉华大学）是联合主要导师 高级学术言语病理学家，在行为临床试验方面拥有丰富的专业知识 干预措施。联合主要导师 Cohen 博士（特拉华大学）是一位以康复为导向的神经心理学家，拥有 多学科认知评估研究记录。 Rodakowski 博士（匹兹堡大学），联合导师，是一位 学术职业治疗师，拥有认知策略培训和独立生活技能方面的专业知识 患有 MCI 的成人。联合导师史密斯博士（佛罗里达大学）是一位资深神经心理学家和 MCI 领域的著名专家， AD 和行为干预方法。研究：大多数 MCI 和痴呆症的治疗方法 AD 的重点是恢复认知缺陷。不幸的是，这些对于保存或 提高独立生活能力。拟议研究的目标 1 是进行试点试验以评估 结构化外部记忆辅助治疗的疗效，这是一种针对患有 MCI 的成人的基于补偿的方法 通过教授使用策略来弥补认知缺陷，从而提高独立生活技能 （例如，笔记系统）。目标 2 是评估人口统计学、临床和神经心理学预测因素 治疗依从性。目标 3 是完善治疗程序和材料，用于培训未来 干预主义者。这些培训和研究目标的完成对于兰子博士的职业生涯至关重要 在研究补偿性认知的功效和有效性方面的发展和持续成功 提高 AD 成人独立性和生活质量的干预措施。