Admin Core

管理核心

基本信息

  • 批准号:
    10339440
  • 负责人:
  • 金额:
    $ 21.4万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2021
  • 资助国家:
    美国
  • 起止时间:
    2021-02-04 至 2026-01-31
  • 项目状态:
    未结题

项目摘要

The Administrative Core A, led by Dr. Richard Wyatt, will administer support for Projects 1 and 2 and Cores B and C, under the umbrella of this new HIVRAD proposal. This Core will coordinate an administrative partnership plan to maintain good communications within the HIVRAD working group and relevant external researchers, advisors and stakeholders related to design of novel cleavage-independent trimers and the analysis of B cell responses generated by vaccination of these HIV-derived envelope glycoprotein (Env) timers into non-human primates (NHPs). The Administrative Core will establish a HIVRAD website as well as cloud data storage accessible to all component PIs or/and designates. A major scientific objective, to elicit and define tier 2 cross- neutralizing B cell and antibody responses (bNAbs) in NHPs following vaccination of novel Env trimers, will be forwarded by Core A. The purpose of Core A is embodied by the successful competition of the following tasks. We will perform project management, while implementing a developed plan to ensure the success of the overall P01 program. This approach will be accomplished by the Program Director, enhanced by real-world learning processes in the accomplished previous Wyatt.Scripps HIVRAD. In Project 2, the Core A will foster studies to better define the expressed NHP heavy and light chain repertoire to determine lineages and the levels of somatic hypermutation elicited by heterologous trimer prime:boost immunization in NHPs. We will examine responses elicited by the novel uncleaved near-native NFL trimers in functional and structural detail to identify neutralizing Abs for genetic analysis. We will use NGS analysis to follow Ab lineages to define affinity maturation, as well as to investigate if the Abs are archived in long-lived compartments (bone marrow). We will apply deep sequencing computational analysis of vaccine-induced Env-specific B cell responses to define populations of epitope-specific Abs in NHPs. We will investigate the evolution of Env-specific Ab lineages following immunization using the NGS-based tracing module within IgDiscover. We will define the maturation pathways of mAbs and use this information to re-design trimer immunogens to drive the responses in broadly neutralizing directions. We will use structural analysis of Env-specific serum Abs (Core C), and isolated mAbs from vaccinated NHPs (Project 2) for iterative trimer redesign. The HIVRAD research team will leverage our previous finding to advances the field's understanding of vaccine-elicited B cell responses to neutralizing determinants of HIV-1 in small animals and NHPs to a level not previously approachable. The continued development of novel B cell sorting probes (ordered cleavage-independent, Avi-tagged NFL trimers), advances in cloning methods, Ab expression, B cell germinal center and lymph node analytical capacities, Ab germline gene identification and Ab lineage tracing through NGS make this an extremely timely and important application. In this new application we will continue “move the bar” forward towards the elicitation of bAbs by subunit Env vaccination using novel, covalent particulate display as well as the exciting recent advances in lipid nanoparticle mRNA expression of cell-surface tethered NFL trimers.
Richard Wyatt博士领导的行政核心A将管理项目1和2以及核心B的支持

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

Richard Thomas Wyatt其他文献

Richard Thomas Wyatt的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('Richard Thomas Wyatt', 18)}}的其他基金

Eliciting neutralizing antibodies and B cell responses using novel HIV Env immunogens in non-human primates
使用新型 HIV Env 免疫原在非人灵长类动物中引发中和抗体和 B 细胞反应
  • 批准号:
    10339439
  • 财政年份:
    2021
  • 资助金额:
    $ 21.4万
  • 项目类别:
Core-002
核心002
  • 批准号:
    10794904
  • 财政年份:
    2021
  • 资助金额:
    $ 21.4万
  • 项目类别:
Project 1
项目1
  • 批准号:
    10339443
  • 财政年份:
    2021
  • 资助金额:
    $ 21.4万
  • 项目类别:
Core-001
核心001
  • 批准号:
    10782243
  • 财政年份:
    2021
  • 资助金额:
    $ 21.4万
  • 项目类别:
Project-002
项目-002
  • 批准号:
    10794919
  • 财政年份:
    2021
  • 资助金额:
    $ 21.4万
  • 项目类别:
Eliciting neutralizing antibodies and B cell responses using novel HIV Env immunogens in non-human primates
使用新型 HIV Env 免疫原在非人灵长类动物中引发中和抗体和 B 细胞反应
  • 批准号:
    10549838
  • 财政年份:
    2021
  • 资助金额:
    $ 21.4万
  • 项目类别:
Admin-Core-001
管理核心-001
  • 批准号:
    10794918
  • 财政年份:
    2021
  • 资助金额:
    $ 21.4万
  • 项目类别:
N-glycan baiting to target the highly effective HIV Env shield
N-聚糖诱饵瞄准高效的 HIV 包膜屏障
  • 批准号:
    10388295
  • 财政年份:
    2019
  • 资助金额:
    $ 21.4万
  • 项目类别:
N-glycan baiting to target the highly effective HIV Env shield
N-聚糖诱饵瞄准高效的 HIV 包膜屏障
  • 批准号:
    9754560
  • 财政年份:
    2019
  • 资助金额:
    $ 21.4万
  • 项目类别:
N-glycan baiting to target the highly effective HIV Env shield
N-聚糖诱饵瞄准高效的 HIV 包膜屏障
  • 批准号:
    10333202
  • 财政年份:
    2019
  • 资助金额:
    $ 21.4万
  • 项目类别:

相似海外基金

The earliest exploration of land by animals: from trace fossils to numerical analyses
动物对陆地的最早探索:从痕迹化石到数值分析
  • 批准号:
    EP/Z000920/1
  • 财政年份:
    2025
  • 资助金额:
    $ 21.4万
  • 项目类别:
    Fellowship
Animals and geopolitics in South Asian borderlands
南亚边境地区的动物和地缘政治
  • 批准号:
    FT230100276
  • 财政年份:
    2024
  • 资助金额:
    $ 21.4万
  • 项目类别:
    ARC Future Fellowships
The function of the RNA methylome in animals
RNA甲基化组在动物中的功能
  • 批准号:
    MR/X024261/1
  • 财政年份:
    2024
  • 资助金额:
    $ 21.4万
  • 项目类别:
    Fellowship
Ecological and phylogenomic insights into infectious diseases in animals
对动物传染病的生态学和系统发育学见解
  • 批准号:
    DE240100388
  • 财政年份:
    2024
  • 资助金额:
    $ 21.4万
  • 项目类别:
    Discovery Early Career Researcher Award
Zootropolis: Multi-species archaeological, ecological and historical approaches to animals in Medieval urban Scotland
Zootropolis:苏格兰中世纪城市动物的多物种考古、生态和历史方法
  • 批准号:
    2889694
  • 财政年份:
    2023
  • 资助金额:
    $ 21.4万
  • 项目类别:
    Studentship
Using novel modelling approaches to investigate the evolution of symmetry in early animals.
使用新颖的建模方法来研究早期动物的对称性进化。
  • 批准号:
    2842926
  • 财政年份:
    2023
  • 资助金额:
    $ 21.4万
  • 项目类别:
    Studentship
Study of human late fetal lung tissue and 3D in vitro organoids to replace and reduce animals in lung developmental research
研究人类晚期胎儿肺组织和 3D 体外类器官在肺发育研究中替代和减少动物
  • 批准号:
    NC/X001644/1
  • 财政年份:
    2023
  • 资助金额:
    $ 21.4万
  • 项目类别:
    Training Grant
RUI: Unilateral Lasing in Underwater Animals
RUI:水下动物的单侧激光攻击
  • 批准号:
    2337595
  • 财政年份:
    2023
  • 资助金额:
    $ 21.4万
  • 项目类别:
    Continuing Grant
RUI:OSIB:The effects of high disease risk on uninfected animals
RUI:OSIB:高疾病风险对未感染动物的影响
  • 批准号:
    2232190
  • 财政年份:
    2023
  • 资助金额:
    $ 21.4万
  • 项目类别:
    Continuing Grant
A method for identifying taxonomy of plants and animals in metagenomic samples
一种识别宏基因组样本中植物和动物分类的方法
  • 批准号:
    23K17514
  • 财政年份:
    2023
  • 资助金额:
    $ 21.4万
  • 项目类别:
    Grant-in-Aid for Challenging Research (Exploratory)
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了