Enhancing Physical Activity Adoption and Maintenance in Adults with Obesity by Understanding Motivation for Exercise: A Mixed Methods Research Design

项目摘要/摘要 体力活动(PA)是持续减肥的最佳预测因素之一，目前的指南建议 高水平的PA，以防止减肥后体重回升。然而，对PA的长期坚持通常是 当为超重/肥胖的成年人提供与现行运动处方一致的运动处方时为穷人 指导方针。因此，评估促进成人采用和维持PA的新策略是至关重要的 超重/肥胖。这个有指导的F32应用程序的总体目标是使用混合方法研究 优化创新的、基于理论的PA干预，旨在增强成年人的运动动机 超重/肥胖。具体而言，将把定量数据(目标1)与定性数据(目标2)结合起来，以 优化旨在增强超重/肥胖成年人运动(运动)动机的干预措施 (目标3)。在目标1中，将使用潜在转换分析来检查以下激励的纵向测量 170名最近完成行为减肥的成年人的运动和客观PA数据收集 试验(R01DK097266)。在AIM 2中，正在进行的行为减肥试验(R01DK111622)的成年人将收到 对搬家进行干预，并参加焦点小组，探索参与者如何体验搬家。在《目标3》中， 定量和定性结果将整合在一起，以优化搬家。申请人丹妮尔·奥斯滕多夫博士 接受慢性病流行病学、临床试验管理和以人为本的研究生培训 分析方法，包括潜在侧写分析。奥斯滕多夫博士的长期目标是开发一种 以预防和治疗慢性病为重点的独立研究方案，包括 肥胖，通过改进策略来增加PA。以她的研究生培训为基础，扩大她的科学研究 技能集，奥斯滕多夫博士和她的指导团队已经制定了一项全面的培训计划。奥斯滕多夫医生的 主要培训目标包括：(1)获得额外的直接临床研究经验；(2) 行为改变理论与策略，(3)潜伏期分析，潜伏期的纵向延伸 分析，(4)定性数据分析和混合方法研究，(5)强化雄心壮志， 出版，以及专业发展技能。这项研究和培训将在华盛顿大学进行 科罗拉多州安舒茨医学院，提供无穷无尽的世界级机会的特殊环境 对于奥斯滕多夫博士来说，获得宝贵的技能和经验将促进她作为一个独立的 研究员。这项提案的成功完成将产生几份第一次创作的出版物，并将 生成支持竞争对手K01应用程序所需的关键初步数据。这份F32提案以及它的 专注于扩大奥斯滕多夫博士在先进统计方法和新研究开发方面的专业知识 混合方法的技能，将既是一个极好的培训机会，也是一种原创和 有意义的科学贡献推动了奥斯滕多夫博士作为一名独立研究员的事业向前发展。

PROJECT SUMMARY/ABSTRACT Physical activity (PA) is one of the best predictors of sustained weight loss and current guidelines recommend high levels of PA to prevent weight regain after weight loss. However, long-term adherence to PA is generally poor when adults with overweight/obesity are provided an exercise prescription consistent with current guidelines. Thus, it is essential to evaluate novel strategies to enhance adoption and maintenance of PA in adults with overweight/obesity. The overall goal of this mentored F32 application is to use mixed methods research to optimize an innovative, theoretically based PA intervention designed to enhance motivation for exercise in adults with overweight/obesity. Specifically, quantitative data (Aim 1) will be integrated with qualitative data (Aim 2) to optimize an intervention designed to enhance MOtiVation for Exercise (MOVE) in adults with overweight/obesity (Aim 3). In Aim 1, a latent transition analysis will be used to examine longitudinal measures of motivation for exercise and objective PA data collected in 170 adults enrolled in a recently completed behavioral weight loss trial (R01DK097266). In Aim 2, adults from an ongoing behavioral weight loss trial (R01DK111622) will receive the MOVE intervention and participate in focus groups to explore how participants experience MOVE. In Aim 3, quantitative and qualitative results will be integrated to optimize MOVE. The applicant, Dr. Danielle Ostendorf, received graduate training in chronic disease epidemiology, clinical trial management, and person-centered analytical approaches including latent profile analysis. Dr. Ostendorf’s long-term goal is to develop an independent research program that focuses on the prevention and treatment of chronic diseases, including obesity, by improving strategies to increase PA. To build upon her graduate training and expand her scientific skillset, Dr. Ostendorf and her mentorship team have developed a comprehensive training plan. Dr. Ostendorf’s primary training objectives include obtaining training in: (1) additional direct clinical research experience, (2) behavior change theory and strategies, (3) latent transition analysis, a longitudinal extension of latent profile analysis, (4) qualitative data analysis and mixed methods research, and (5) strengthening granstmanship, publishing, and professional development skills. This research and training will take place at the University of Colorado Anschutz Medical Campus, an exceptional environment that offers endless world-class opportunities for Dr. Ostendorf to gain valuable skills and experiences that will foster her development as an independent researcher. Successful completion of this proposal will result in several first-authored publications and will generate critical preliminary data needed to support a competitive K01 application. This F32 proposal, with its focus on expanding Dr. Ostendorf’s expertise in advanced statistical methods and development of new research skills in mixed methods approaches, will serve as both a superb training opportunity and as an original and meaningful scientific contribution to propel Dr. Ostendorf’s career forward as an independent investigator.