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Pulmonary Immunopathology

肺部免疫病理学

基本信息

批准号：
10341063
负责人：
Yogesh Saini
金额：
$ 31.15万
依托单位：
LOUISIANA STATE UNIV A&M COL BATON ROUGE
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-01-02 至 2023-12-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10341063
关键词：
Acute Lung Injury Address Allergens Animal Husbandry Animals Bacteria Biology Biomedical Research Bronchoalveolar Lavage Fluid Cardiovascular Diseases Cell Culture Techniques Cell Separation Cells Censuses Centers of Research Excellence Collaborations Communities Computer software Consult Consultations Containment of Biohazards Contract Services Data Data Correlations Disease Disease model Educational workshop Ensure Enzyme-Linked Immunosorbent Assay Equipment Experimental Designs Extrinsic asthma Faculty Faculty Recruitment Flow Cytometry Funding Future Genetic Engineering Genetically Engineered Mouse Genotype Goals Heart Rate Histologic Histology Histopathology Immunohistochemistry Immunologics Immunology Individual Infection Inflammation Inflammatory Influenza Institution Knock-out Laboratories Lesion Louisiana Lung Lung diseases Maintenance Measurement Measures Microbe Modeling Mus Organ Outcome Pathogenesis Pathologic Pathologist Phase Physiological Physiology Postdoctoral Fellow Preparation Productivity Reagent Research Research Personnel Resources Sampling Serum Services Standardization Structure Students Techniques Temperature Training Training and Education Transgenic Mice Tuberculosis Underrepresented Minority United States National Institutes of Health Update Viral airway inflammation chemokine cytokine experience graduate student immunopathology instrumentation laser capture microdissection lectures member microbial morphometry mouse model programs pulmonary function recruit repaired success undergraduate student

项目摘要

PROJECT SUMMARY Pulmonary Immunopathology (PIP) core offers expertise and technical support for investigators in the COBRE program. The goal of the proposed PIP Core is to provide animal and equipment facilities and specialized training for COBRE PJIs in pulmonary immunopathological techniques and to develop new experimental approaches that will assist Promising Junior Investigators (PJls) and other NIH-funded investigators to successfully pursue their research objectives. The establishment of this core will facilitate collaboration among investigators and members of the biomedical research community in Louisiana. This core will also educate our underrepresented minority (URM) undergraduate students, graduate students, postdoctoral fellows, summer scholars (DVM Students) with the application and the current advances in pulmonary immunology through lectures, laboratory classes, and workshops. In order to ensure the success of the COBRE in Lung Biology and Disease and of our COBRE PJIs, establishment of the PIP Core is essential to meet the current and future needs of LSU and other institutions because this is the only PIP core in the state of Louisiana. Thus, the PIP Core is intended to be a permanent core at LSU that we will establish, expand, and transit to an independent core during the 15-year COBRE support. The PIP Core has established 3 specific aims. Aim 1 is to centralize management of wild-type (control) and mouse genetically engineered mouse colonies and immunological reagents. Aim 2 is to provide the COBRE and other biomedical investigators with resources on comprehensive immunopathological assessments for mice, including instrumentation, technical support and consultation. Aim 3 is to educate faculty, staff, postdoctoral fellows, graduate students, undergraduate students and summer scholars regarding the application and the current advances in immunopathological assessments for mice.

项目概要肺免疫病理学 (PIP) 核心为 COBRE 的研究人员提供专业知识和技术支持程序。拟议的 PIP 核心的目标是提供动物和设备设施以及专门对 COBRE PJI 进行肺部免疫病理学技术培训并开发新的实验将帮助有前途的初级研究人员（PJls）和其他 NIH 资助的研究人员的方法成功地实现他们的研究目标。该核心的建立将促进双方的合作路易斯安那州生物医学研究界的研究人员和成员。该核心还将教育我们的弱势少数群体 (URM) 本科生、研究生、博士后研究员、暑期学者（DVM 学生）了解肺病的应用和当前进展通过讲座、实验室课程和讲习班来学习免疫学。为了确保此次活动的成功 COBRE 在肺生物学和疾病以及我们的 COBRE PJI 中，PIP 核心的建立对于满足路易斯安那州立大学和其他机构当前和未来的需求，因为这是该州唯一的 PIP 核心路易斯安那州。因此，PIP 核心旨在成为路易斯安那州立大学的永久核心，我们将建立、扩展和在 15 年 COBRE 支持期间过渡到独立核心。 PIP Core 建立了 3 个特定的目标。目标1是集中管理野生型（对照）和小鼠基因工程小鼠菌落和免疫试剂。目标 2 是为 COBRE 和其他生物医学研究人员提供有关小鼠综合免疫病理学评估的资源，包括仪器、技术支持和咨询。目标 3 是教育教职员工、博士后、研究生、本科生和暑期学者关于应用和当前进展对小鼠进行免疫病理学评估。