Pulmonary Immunopathology

肺部免疫病理学

• 批准号: 10341063
• 负责人: Yogesh Saini
• 金额: $ 31.15万
• 依托单位: LOUISIANA STATE UNIV A&M COL BATON ROUGE
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-01-02 至 2023-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10341063
• 关键词: Acute Lung Injury; Address; Allergens; Animal Husbandry; Animals; Bacteria; Biology; Biomedical Research; Bronchoalveolar Lavage Fluid; Cardiovascular Diseases; Cell Culture Techniques; Cell Separation; Cells; Censuses; Centers of Research Excellence; Collaborations; Communities; Computer software; Consult; Consultations; Containment of Biohazards; Contract Services; Data; Data Correlations; Disease; Disease model; Educational workshop; Ensure; Enzyme-Linked Immunosorbent Assay; Equipment; Experimental Designs; Extrinsic asthma; Faculty; Faculty Recruitment; Flow Cytometry; Funding; Future; Genetic Engineering; Genetically Engineered Mouse; Genotype; Goals; Heart Rate; Histologic; Histology; Histopathology; Immunohistochemistry; Immunologics; Immunology; Individual; Infection; Inflammation; Inflammatory; Influenza; Institution; Knock-out; Laboratories; Lesion; Louisiana; Lung; Lung diseases; Maintenance; Measurement; Measures; Microbe; Modeling; Mus; Organ; Outcome; Pathogenesis; Pathologic; Pathologist; Phase; Physiological; Physiology; Postdoctoral Fellow; Preparation; Productivity; Reagent; Research; Research Personnel; Resources; Sampling; Serum; Services; Standardization; Structure; Students; Techniques; Temperature; Training; Training and Education; Transgenic Mice; Tuberculosis; Underrepresented Minority; United States National Institutes of Health; Update; Viral; airway inflammation; chemokine; cytokine; experience; graduate student; immunopathology; instrumentation; laser capture microdissection; lectures; member; microbial; morphometry; mouse model; programs; pulmonary function; recruit; repaired; success; undergraduate student

PROJECT SUMMARY Pulmonary Immunopathology (PIP) core offers expertise and technical support for investigators in the COBRE program. The goal of the proposed PIP Core is to provide animal and equipment facilities and specialized training for COBRE PJIs in pulmonary immunopathological techniques and to develop new experimental approaches that will assist Promising Junior Investigators (PJls) and other NIH-funded investigators to successfully pursue their research objectives. The establishment of this core will facilitate collaboration among investigators and members of the biomedical research community in Louisiana. This core will also educate our underrepresented minority (URM) undergraduate students, graduate students, postdoctoral fellows, summer scholars (DVM Students) with the application and the current advances in pulmonary immunology through lectures, laboratory classes, and workshops. In order to ensure the success of the COBRE in Lung Biology and Disease and of our COBRE PJIs, establishment of the PIP Core is essential to meet the current and future needs of LSU and other institutions because this is the only PIP core in the state of Louisiana. Thus, the PIP Core is intended to be a permanent core at LSU that we will establish, expand, and transit to an independent core during the 15-year COBRE support. The PIP Core has established 3 specific aims. Aim 1 is to centralize management of wild-type (control) and mouse genetically engineered mouse colonies and immunological reagents. Aim 2 is to provide the COBRE and other biomedical investigators with resources on comprehensive immunopathological assessments for mice, including instrumentation, technical support and consultation. Aim 3 is to educate faculty, staff, postdoctoral fellows, graduate students, undergraduate students and summer scholars regarding the application and the current advances in immunopathological assessments for mice.

项目摘要 肺免疫病理学（PIP）核心为COBRE的研究人员提供专业知识和技术支持 程序.拟议的PIP核心的目标是提供动物和设备设施， 为COBRE PJI提供肺部免疫病理学技术培训并开发新的实验 这些方法将帮助有前途的初级研究者（PJls）和其他NIH资助的研究者， 成功地实现了自己的研究目标。该核心的建立将促进 研究人员和路易斯安那州生物医学研究社区的成员。该核心还将 教育我们的代表性不足的少数民族（URM）本科生，研究生，博士后 研究员，暑期学者（DVM学生）与肺的应用和目前的进展 免疫学通过讲座，实验室课程和研讨会。为了确保成功， COBRE在肺部生物学和疾病以及我们的COBRE PJIs中，PIP核心的建立对于 满足路易斯安那州立大学和其他机构的当前和未来的需求，因为这是唯一的PIP核心的状态， 方面应受中华因此，PIP核心旨在成为路易斯安那州立大学的永久核心，我们将建立，扩大， 在15年的COBRE支持期间过渡到独立核心。PIP核心已制定3项具体措施 目标。目的1是实现野生型（对照）和小鼠基因工程小鼠的集中管理 集落和免疫试剂。目标2是为COBRE和其他生物医学研究人员提供 关于小鼠全面免疫病理学评估的资源，包括仪器，技术 支持和咨询。目标3是教育教职员工、博士后研究员、研究生， 本科生和暑期学者关于应用程序和目前的进展， 小鼠的免疫病理学评估。