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Multidisciplinary Research Training to Understand and Reduce HIV Incidence in Uganda

多学科研究培训以了解和减少乌干达的艾滋病毒发病率

基本信息

批准号：
10341059
负责人：
Larry William Chang
金额：
$ 29.54万
依托单位：
JOHNS HOPKINS UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-05-10 至 2024-01-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10341059
关键词：
Acquired Immunodeficiency Syndrome Address Adopted Africa African Area Caring Case Study Cessation of life Clinic Communicable Diseases Communities Country Discipline Doctor of Philosophy Educational Status Ensure Epidemic Foundations Geographic Locations Goals HIV HIV Infections HIV Wasting Syndrome Health Sciences Immunology Incidence Infection Institution Interdisciplinary Study Male Circumcision Modeling Modernization Monitor Outcome Policies Positioning Attribute Public Health Schools Publishing Reporting Research Research Training Science Services Testing Training Uganda United States National Institutes of Health Universities antiretroviral therapy beneficiary high risk sexual behavior implementation science improved interdisciplinary approach multidisciplinary pre-exposure prophylaxis programs response scale up transmission process virology

项目摘要

While substantial progress have been made in the global HIV response, impact have been uneven. Uganda provides a prime case study. Uganda was an early epicenter of the epidemic, with the first report of “slim disease” in East Africa published by our group in 1985. Over the next two decades, Uganda was a leader in efforts to control the epidemic. More recently, new HIV infections remain substantial, particularly in hard-to- reach subpopulations, and the modern Ugandan response to the HIV epidemic presents an improving but mixed picture. Despite moderate scale-up of HIV services, it is estimated that there are still approximately 28,000 yearly AIDS-related deaths and 83,000 new infections in the setting of suboptimal antiretroviral therapy and male circumcision coverage. High mobility, suboptimal linkage and retention in care, persistent high risky sexual behaviors, and an incomplete understanding of HIV transmission dynamics continue to compromise an optimal response. Adding to these challenges are the increasing identification of HIV “hotspots” in Uganda, geographic areas of high HIV burden, where HIV services are often limited. Uganda, like most PEPFAR countries, has adopted more aggressive approaches, including Test and Treat All and introducing Pre- Exposure Prophylaxis (PrEP). However, the impact of these approaches is unclear and will need close monitoring to understand their implementation and impact. This complexities of HIV transmission dynamics and responses raise many critical research questions which impact both Ugandan and Sub-Saharan African policies and programs. In order to address these research areas, it is essential that local capacity be strengthened. In particular, we believe capacity must be built in a multidisciplinary fashion to better understand and reduce HIV incidence in Uganda and beyond, a high priority NIH research area. Our group has a long and successful legacy of training leaders in HIV research and are strongly positioned to build upon this foundation. We propose a multidisciplinary approach to developing scientific capacity in Uganda which will emphasize 3 synergistic areas: (1) Implementation Science, (2) Geospatial Analysis/Infectious Disease Dynamics and (3) Virology/Immunology/HIV Cure. These disciplines span the clinic, community, modeling, and the lab sciences and will ensure that we reach the long-term goals and objectives of the program, which are that Ugandan institutions will have the research capacity needed to understand, respond to, and eventually control the HIV epidemic. We will involve 22 trainees in multidisciplinary bachelor, master's, PhD, and post- graduate level training, mostly in Uganda. The primary beneficiaries of this training will be the Rakai Health Sciences Program and the Makerere University School of Public Health in Uganda with whom Johns Hopkins University, the applicant institution, has had a highly successful collaborative relationship for 30 years. Our anticipated outcome is to have developed a world-class cadre of Ugandan research capacity capable of leading Uganda to the end of its HIV epidemic.

虽然全球艾滋病毒防治工作取得了重大进展，但影响参差不齐。乌干达

项目成果

期刊论文数量（6）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Results of Early Virologic Monitoring May Facilitate Differentiated Care Monitoring Strategies for Clients on ART, Rakai, Uganda.

早期病毒学监测结果可能有助于为 ART 客户制定差异化护理监测策略，乌干达拉凯。

DOI：
10.1093/ofid/ofy212
发表时间：
2018
期刊：
Open forum infectious diseases
影响因子：
4.2
作者：
Ssempijja,Victor;Chang,LarryW;Nakigozi,Gertrude;Ndyanabo,Anthony;Quinn,ThomasC;Cobelens,Frank;Wawer,Maria;Gray,Ronald;Serwadda,David;Reynolds,StevenJ
通讯作者：
Reynolds,StevenJ

Effectiveness of intensive adherence counselling in achieving an undetectable viral load among people on antiretroviral therapy with low-level viraemia in Uganda.

在乌干达接受抗逆转录病毒治疗的低水平病毒血症人群中，强化依从性咨询对于实现不可检测的病毒载量的有效性。

DOI：
10.1111/hiv.13568
发表时间：
2024
期刊：
HIV medicine
影响因子：
3
作者：
Nanyeenya,Nicholus;Nakanjako,Damalie;Makumbi,Fredrick;Nakigozi,Gertrude;Nalugoda,Fred;Kigozi,Godfrey;Nasuuna,Esther;Kibira,SimonPS;Nabadda,Susan;Kiyaga,Charles;Huzaifah,Mutyaba;Kiwanuka,Noah
通讯作者：
Kiwanuka,Noah

Adaptive Viral Load Monitoring Frequency to Facilitate Differentiated Care: A Modeling Study From Rakai, Uganda.

自适应病毒载量监测频率以促进差异化护理：乌干达拉凯的一项建模研究。

DOI：
10.1093/cid/ciz880
发表时间：
2020
期刊：
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
影响因子：
0
作者：
Ssempijja,Victor;Nason,Martha;Nakigozi,Gertrude;Ndyanabo,Anthony;Gray,Ron;Wawer,Maria;Chang,LarryW;Gabriel,Erin;Quinn,ThomasC;Serwadda,David;Reynolds,StevenJ
通讯作者：
Reynolds,StevenJ

Cardiovascular (Framingham) and type II diabetes (Finnish Diabetes) risk scores: a qualitative study of local knowledge of diet, physical activity and body measurements in rural Rakai, Uganda.