Aberrant nerve excitability: An in-depth study of HCN channel activity in neurological disorders (epilepsy and chronic neuropathic pain).

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Chronic neuropathic pain and epilepsy carry a high burden of disease, and have a major impact on health resources. Abnormal nerve excitability is implicated in both conditions. This study evaluates the use of a non-invasive test applied to peripheral nerve in the measurement of nerve excitability in neuropathic pain and epilepsy. The aim is to establish a sensitive biomarker of disease in assessment and diagnosis of patients, and to help direct therapy and measure response to treatment.