Health Disparities in Alzheimers and Related Diseases

这份来自佛罗里达国际大学(FIU)和埃默里大学的申请请求提供为期四年的支持 研究会议系列讨论与减少阿尔茨海默氏症相关的关键科学问题 和相关痴呆症(ADRD)在美国少数族裔之间的不平等。系列会议 我们建议利用人口疾病框架进行跨学科研究，并特别关注 神经退行性疾病发病途径的种族和性别差异。遗传学与家庭/个人 健康史是不可改变的因素，而可改变的因素包括广泛的环境寿命 暴露和生活方式因素。这一系列会议的重点是加深对基因如何 这些因素与环境暴露、家庭和个人健康史以及生活方式是一致的。 在族裔群体内部和之间产生增加或减少ADRD风险的相互作用的因素， 特别是在非裔美国人、拉丁裔和非拉丁裔白人中。这些关键问题在很大程度上仍然存在 被忽视了，并且是增加使用精确医学和 在AD代表不足的人群中进行药理学和非药理学干预研究 临床试验。本系列相关的4个具体目标是：1.了解当前证据是如何审查的 特定的基因，无论是单独的还是组合的，都按种族和性别不同地分布，并且 与高危族群之间的较高风险或针对负荷的保护有关。2.至 描述遗传风险如何受表观遗传学、年龄、性别、环境暴露、 生活方式/饮食、家庭和个人健康史、种族之间和种族内的社会和人口因素 人群和妇女的负载风险不成比例。3.检查目前关于并存的知识如何 如血管疾病、糖尿病和精神健康在这些人中适度或中介增加ADRD的风险 未被充分代表的人群。4.探索基本理论、新发现和创新观察， 用于受访者或患者评估以及测量/分析的仪器开发和校准 提高我们对影响ADRD风险的基因x环境相互作用以及如何影响的理解的策略 方法可能会被修改或调整，以用于风险较高的少数人的特定研究应用 人口和妇女。

This application from Florida International University (FIU) and Emory University requests support for a four-year research conference series to address critical scientific issues associated with reducing Alzheimer's Disease and Related Dementia (ADRD) inequities among ethnic minorities in the United States. The conference series we propose rests on interdisciplinary research using a population disease framework, with specific attention to ethnic groups and sex differences in pathways to neurodegenerative diseases. Genetics and family/personal health histories are non-modifiable factors, and modifiable factors include a wide range of lifespan environmental exposures and lifestyle factors. The conference series focuses on increasing understanding about how genetic factors are operating in concert with environmental exposures, family and personal health histories, and lifestyle factors to produce interactions that enhance or mitigate risk of ADRD within and between ethnic groups, specifically among African Americans, Latinos, and non-Latino Whites. These critical issues remain largely overlooked and are fundamental for increasing knowledge for disease modification using precision medicine and for pharmacologic and non-pharmacologic intervention development in under-represented populations in AD clinical trials. The 4 related specific aims of the series are: 1. To understand how the current evidence examines specific genes, individually or in combination, are differentially distributed by ethnicity and sex, and are associated with higher risk or protection against LOAD between and among higher risk ethnic groups. 2. To describe how genetic risk may be modulated by factors such as epigenetics, age, sex, environmental exposures, lifestyle/diet, family and personal health histories, social, and demographic factors between and within ethnic groups and women at disproportionate risk for LOAD. 3. To examine current knowledge about how comorbidities such as vascular diseases, diabetes, and mental health moderate or mediate the increase risk of ADRD in these under-represented populations. 4. To explore underlying theory, new findings, and innovative observation, instrument development and calibration for respondent or patient assessment, and measurement/analytic strategies to improve our understanding of the gene x environment interactions influencing ADRD risk and how methods may be modified or adapted for use in specific research applications with higher risk minority populations and women.