Michigan State University VDL Vet-LIRN 2021

密歇根州立大学 VDL Vet-LIRN 2021

• 批准号: 10449684
• 负责人: KIMBERLY DODD
• 金额: $ 4.45万
• 依托单位: MICHIGAN STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-06 至 2022-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10449684
• 关键词: Michigan; State; University; VDL; Vet

PAR-18-604 Vet-LIRN Network Capacity-Building Project Michigan State University Project Summary The Toxicology Section of the Michigan State University Veterinary Diagnostic Laboratory works in coordination with the FDA Vet-LIRN and the Food Emergency Response Network (FERN) to monitor, test, and report on chemical food contaminants in an effort to provide effective communication of laboratory findings to protect the nation’s food/feed supply. Testing of food products for chemical residues, including antimicrobial drugs and the naturally occurring fungal contaminant mycotoxins, are routinely performed by liquid chromatography tandem mass spectrometry. Newer methods for the detection of multiple drug residues in food products (Becker et al, 2004; Aguilera-Luiz et al, 2008; Heller et al, 2006, Tang et al, 2012) have been described for ultra-high performance liquid chromatography tandem mass spectrometers. The recent acquisition of a UPLC-MS/MS has greatly enhanced our capabilities and provides surge capacity with high throughput for Vet-LIRN and FERN- directed product testing. However, the current system LC-MS/MS system makes use of nitrogen cylinders instead of a continuous source of high purity gas. Additionally, sample preparation time is currently limited by the ability to remove solvent by gas evaporation. The acquisition of a nitrogen generator and a nitrogen evaporation unit will allow for increased sample capacity and throughput without interruption in analytical testing.

PAR-18-604 VET-LIRN网络能力建设项目 密歇根州立大学 项目摘要 密歇根州立大学兽医诊断实验室毒物科协同工作 与FDA Vet-LIRN和食品应急网络(FERN)一起监测、测试和报告 化学食物污染物，努力提供有效的实验室结果沟通，以保护 国家的食物/饲料供应。检测食品中的化学残留物，包括抗菌药物和 自然产生的真菌污染霉菌毒素，通常通过液相色谱串联进行检测 质谱学。用于检测食品中多种药物残留的新方法(Becker等人， 2004年；Aguera-Luiz等人，2008；Heller等人，2006，Tang等人，2012)被描述为超高 高效液相色谱串联质谱仪。最近收购了一台UPLC-MS/MS 极大地增强了我们的能力，并为Vet-LIRN和FERN提供高吞吐量的浪涌容量- 定向产品测试。然而，当前系统的LC-MS/MS系统使用氮气瓶 而不是一个连续的高纯度气体来源。此外，样品准备时间目前受到以下限制 通过气体蒸发除去溶剂的能力。获得一个氮气发生器和一个氮气 蒸发装置将允许在不中断分析测试的情况下增加样品容量和吞吐量。