Focused ultrasound-enabled brain tumor liquid biopsy (FUS-LBx) supplement
聚焦超声脑肿瘤液体活检 (FUS-LBx) 补充剂
基本信息
- 批准号:10448708
- 负责人:
- 金额:$ 13.54万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-08-19 至 2024-04-30
- 项目状态:已结题
- 来源:
- 关键词:AddressAnimalsApplications GrantsAutomobile DrivingBiological MarkersBiopsyBloodBlood - brain barrier anatomyBlood CirculationBrainBrain DiseasesBrain NeoplasmsCardiovascular systemClinicalClinical ManagementDNADataDetectionDevelopmentDevicesDiagnosisDiseaseExcisionFamily suidaeFocused UltrasoundFutureGoalsHistologicImageLearningLiquid substanceLocationMagnetic Resonance ImagingMalignant NeoplasmsMalignant neoplasm of brainMedicalMicrobubblesMolecularMolecular ProfilingMonitorNational Institute of Biomedical Imaging and BioengineeringOperative Surgical ProceduresParentsPatient MonitoringPatientsPolymerase Chain ReactionProteinsPublic HealthRNAResearchRiskSamplingSmall Business Innovation Research GrantSmall Business Technology Transfer ResearchSpectrum AnalysisTechniquesTissuesTumor MarkersTumor-DerivedUnited StatesUnited States National Institutes of HealthWorkbaseclinical translationcommercializationcontrolled releasedesigndetection methoddigitalextracellular vesiclesliquid biopsyneoplastic cellneuroimagingnext generation sequencingnovelpatient populationpre-clinicalprogramssafety and feasibilitytooltreatment responsetumortumor progression
项目摘要
PROJECT SUMMARY/ABSTRACT
This application is for the NIBIB C3i Accell program. The objective of our parent R01 application
(R01EB030102, Project Period: 08/01/2020–04/30/2024) is to perform small animal and large animal studies to
obtain compelling preclinical evidence needed to support future clinical translation of focused ultrasound-enabled
liquid biopsy (sonobiopsy). Through learnings from NIBIB’s C3i programs, we identified that one key risk
toward commercialization of our technique is the need to optimize the design of the sonobiopsy device
for clinical use and validated its feasibility and safety in biomarker release. The objective of our proposed
research for the C3i Accell program is to address this key technical risk. Successful completion of this work will
obtain data that will support our start-up company’s NIH SBIR/STTR grant application to further commercial
development efforts.
项目总结/摘要
此应用程序用于NIBIB C3 i Accell程序。我们的父R 01应用程序的目标
(R 01 EB 030102,项目周期:2020年8月1日至2024年4月30日)进行小动物和大动物研究,
获得支持聚焦超声的未来临床转化所需的令人信服的临床前证据,
液体活检(超声活检)。通过从NIBIB的C3 i项目中学习,我们确定了一个关键风险
为了使我们的技术商业化,需要优化声活检装置的设计
并验证了其生物标志物释放的可行性和安全性。我们提出的目标是
C3 i Accell计划的研究就是为了解决这一关键技术风险。这项工作的顺利完成将
获得数据,将支持我们的初创公司的NIH SBIR/STTR赠款申请,以进一步商业化
发展努力。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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{{ truncateString('Hong Chen', 18)}}的其他基金
Role of PXR in drug-elicited cardiovascular disease
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- 批准号:
10576675 - 财政年份:2022
- 资助金额:
$ 13.54万 - 项目类别:
Sonobiopsy for Noninvasive Genetic Evaluation of Glioblastoma Patients
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- 资助金额:
$ 13.54万 - 项目类别:
The Role of Adaptor Protein Disabled-2 in Maintaining Endothelial Cell Function in Atherosclerosis
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10532247 - 财政年份:2021
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$ 13.54万 - 项目类别:
iSonogenetics for incisionless cell-type-specific neuromodulation of non-human primate brains
非人类灵长类大脑的无切口细胞类型特异性神经调节的声遗传学
- 批准号:
10655585 - 财政年份:2021
- 资助金额:
$ 13.54万 - 项目类别:
The Role of Adaptor Protein Disabled-2 in Maintaining Endothelial Cell Function in Atherosclerosis
接头蛋白Disabled-2在维持动脉粥样硬化内皮细胞功能中的作用
- 批准号:
10391797 - 财政年份:2021
- 资助金额:
$ 13.54万 - 项目类别:
iSonogenetics for incisionless cell-type-specific neuromodulation of non-human primate brains
非人类灵长类大脑的无切口细胞类型特异性神经调节的声遗传学
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- 资助金额:
$ 13.54万 - 项目类别:
Molecular Mechanisms Governing Vascular Cell Function and Phenotype in Health and Disease
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10600825 - 财政年份:2021
- 资助金额:
$ 13.54万 - 项目类别:
Molecular Mechanisms Governing Vascular Cell Function and Phenotype in Health and Disease
健康和疾病中控制血管细胞功能和表型的分子机制
- 批准号:
10380102 - 财政年份:2021
- 资助金额:
$ 13.54万 - 项目类别:
The role of signaling adaptor protein epsin in atherosclerosis
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- 批准号:
10318660 - 财政年份:2020
- 资助金额:
$ 13.54万 - 项目类别:
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