Squirrel Monkey Breeding and Research Resource

项目概要：总体组成部分 此次申请是对“松鼠猴繁育与研究资源”的竞争性更新 （SMBRR）P40 OD 010938，自1980年以来一直获得NIH的资助。SMBRR是 只有国家研究资源的松鼠猴提供给美国国立卫生研究院赠款，校内研究计划 FDA、NSF和NIH等联邦机构以及其他生物医学研究赞助商（私人） 基金会、制药公司和合同研究组织）。因为玻利维亚松鼠 猴子不再能从来源国获得，也没有其他的纯种繁殖地。 可用于生物医学研究的松鼠猴，SMBRR是一种独特的研究资源， 被复制或替换。松鼠猴的稀缺，圈养繁殖的困难， 以及与它们的护理和在研究中的使用相关的挑战，都有助于这种国家的需要， 研究资源。SMBRR将多个学科整合到一个旨在满足需求的计划中 利用其资源的调查人员。在未来几年，SMBRR将继续改善 它提供的资源，并继续增加有关松鼠生物学和研究价值的新信息 猴子松鼠猴仍然是神经科学研究中的重要动物模型， 成瘾研究、疟疾疫苗研究和基础进化生物学。在接下来的五年里， SMBRR将专注于改进动物和相关资源，以满足科学研究的需要。 社区资源核心部分的目标是继续致力于实现 研究界对松鼠猴的需求和使用松鼠猴的信息 在研究中。我们将在回顾性流行病学研究中探讨围产儿死亡的原因。我们将 从Saimiri boliviensis boliviensis中产生长读基因组序列，并将我们的生物库扩展到 包括来自该资源的特定DNA来源。应用组件研究项目侧重于基础 这些研究项目将增强使用松鼠猴的生物医学模型。这些研究包括定义 以及描述松鼠猴中不同种类的单核细胞， 微生物组在不同年龄的动物分类。我们也将开始测试成年人的记忆， 老年松鼠猴种群使用计算机辅助学习方法。的总体目标 SMBRR将提供松鼠猴的国家研究资源;提供松鼠猴 生物材料;为希望从事生物材料研究的科学家提供教育和培训机会; 与松鼠猴，殖民地管理者和动物护理人员;并为调查人员提供 利用松鼠猴进行研究的设施和专业知识。

PROJECT SUMMARY: OVERALL COMPONENT This application is a competing renewal of the “Squirrel Monkey Breeding and Research Resource” (SMBRR) P40 OD010938 which has received continuous NIH grant support since 1980. The SMBRR is the only national research resource of squirrel monkeys available to NIH grantees, intramural research programs of federal agencies including the FDA, NSF, and the NIH, and other sponsors of biomedical research (private foundations, pharmaceutical companies, and contract research organizations). Because Bolivian squirrel monkeys are no longer available from source countries, and there are no other breeding colonies of pedigreed squirrel monkeys available for biomedical research, the SMBRR is a unique research resource that cannot be duplicated or replaced. The scarcity of squirrel monkeys, difficulties associated with captive breeding, as well as the challenges associated with their care and use in research, all contribute to the need for this national research resource. The SMBRR has integrated multiple disciplines into a program designed to meet the needs of investigators who utilize its resources. In the upcoming years, the SMBRR will continue to improve the resources it provides and continue to add new information about the biology and research value of squirrel monkeys. Squirrel monkeys continue to be an important animal model in neuroscience research, drug addiction research, malaria vaccine research, and fundamental evolutionary biology. Over the next five years, the SMBRR will focus on refining the animals and related resources to meet the needs of the scientific community. The aims of the Resource Core Component address our continued commitment to meeting the needs of the research community for access to squirrel monkeys and information about using squirrel monkeys in research. We will explore the causes of perinatal mortality in a retrospective epidemiology study. We will produce a long read genome sequence from a Saimiri boliviensis boliviensis and extend our BioBank to include specific DNA sources from the resource. The Applied Component research projects focus on basic research projects that will enhance biomedical models using squirrel monkeys. These studies include defining and characterizing the different classes of monocytes in squirrel monkeys, as well as characterizing the gut microbiome in differing age classifications of animals. We will also begin to test memory in our adult and geriatric squirrel monkey populations using computer assisted learning methods. The overall goals of the SMBRR are to provide a national research resource of squirrel monkeys; provide squirrel monkey derived biological materials; provide education and training opportunities to scientists wishing to work with squirrel monkeys, colony managers, and animal caregivers; and provide investigators with facilities and expertise to conduct studies using squirrel monkeys.