Characterizing the Metabolome and Volatilome of Gut Microbiome

表征肠道微生物组的代谢组和挥发物组

基本信息

  • 批准号:
    10455054
  • 负责人:
  • 金额:
    $ 35.76万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2019
  • 资助国家:
    美国
  • 起止时间:
    2019-09-01 至 2024-07-31
  • 项目状态:
    已结题

项目摘要

Project Summary: Previous studies have shown that microbial metabolites are often the compounds most markedly altered in the disease state when comparing diseased versus healthy individuals. Recent studies also suggest that metabolites deriving from microbial transformation of dietary components have significant effects on host physiological processes such as energy metabolism, gut and immune homeostasis, neurological behavior, and vascular function. Additionally, it has been proposed that metabolomics-directed functional interventions using exogenous metabolites may play critical biological roles in cellular activities. However, there are no existing, detailed, and quantitative techniques for the measurement of a broad range of endogenous microbial metabolites, nor has there been a systematic investigation of microbial communities for their metabolic functions. To fill the existing gap of knowledge, the research program outlined in this proposal focuses on three core areas: 1) Develop advanced mass spectrometry-based metabolomics technique for sensitive, quantitative detection and broad coverage of gut microbial metabolites; 2) Develop Secondary Electrospray Ionization – Field Asymmetric Waveform Ion Mobility Spectrometry – High-Resolution Mass Spectrometry (SESI-FAIMS- HRMS) for the rapid detection of gut microbial volatile organic compound detection; 3) Utilizing existing samples from our collaborator's lab to validate our metabolomics methods and elucidate the functionality of catechins microbial metabolites in obese host. These three coherent areas center on the development and application of mass spectrometry-based metabolomics, volatilomics and related microbial biotechnology tools to enable functional studies of microbial metabolism and nutrition-gut microbiome-host interactions. We believe this research program has great potential to elucidate the impact of microbial metabolites on host health and diseases, and to provide guidelines for modulating these metabolites to realize the full therapeutic potential, and for targeting microbial metabolism to promote human health.
项目总结:

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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Jiangjiang Zhu其他文献

Jiangjiang Zhu的其他文献

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{{ truncateString('Jiangjiang Zhu', 18)}}的其他基金

Characterizing the Metabolome and Volatilome of Gut Microbiome
表征肠道微生物组的代谢组和挥发物组
  • 批准号:
    9797445
  • 财政年份:
    2019
  • 资助金额:
    $ 35.76万
  • 项目类别:
Characterizing the Metabolome and Volatilome of Gut Microbiome
表征肠道微生物组的代谢组和挥发物组
  • 批准号:
    10681064
  • 财政年份:
    2019
  • 资助金额:
    $ 35.76万
  • 项目类别:
Characterizing the Metabolome and Volatilome of Gut Microbiome
表征肠道微生物组的代谢组和挥发物组
  • 批准号:
    10228680
  • 财政年份:
    2019
  • 资助金额:
    $ 35.76万
  • 项目类别:
Characterizing the Metabolome and Volatilome of Gut Microbiome
表征肠道微生物组的代谢组和挥发物组
  • 批准号:
    10000182
  • 财政年份:
    2019
  • 资助金额:
    $ 35.76万
  • 项目类别:
Characterizing the Metabolome and Volatilome of Gut Microbiome
表征肠道微生物组的代谢组和挥发物组
  • 批准号:
    10676167
  • 财政年份:
    2019
  • 资助金额:
    $ 35.76万
  • 项目类别:

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