Boosting mind-body mechanisms for mitigating neuroinflammation in migraine

增强身心机制以减轻偏头痛的神经炎症

• 批准号: 10456011
• 负责人: Marco Luciano Loggia
• 金额: $ 67.79万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-08-01 至 2024-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10456011
• 关键词: Aftercare; Animals; Anti-Inflammatory Agents; Astrocytes; Attitude; Awareness; Brain; Brain Stem; Cell Nucleus; Clinical; Coupled; Coupling; Data; Data Set; Disease; Education; Fiber; Frequencies; Functional Magnetic Resonance Imaging; Functional disorder; Generations; Healthcare Systems; Institute of Medicine (U.S.); Insula of Reil; Intervention; Intervention Studies; Ligand Binding; Link; Magnetic Resonance; Measurable; Measures; Mediating; Mediation; Medical; Methods; Microglia; Migraine; Mind; Mind-Body Intervention; Molecular; Neurobiology; Outcome; Pain; Patients; Planets; Positron-Emission Tomography; Proteins; Reporting; Role; Scanning; Severities; Signal Transduction; Spreading Cortical Depression; Testing; Thalamic structure; Therapeutic; Transcutaneous Electric Nerve Stimulation; active method; afferent nerve; arm; body-mind; chronic pain; chronic pain patient; chronic painful condition; design; experience; glial activation; improved; mindfulness; mindfulness meditation; mindfulness-based stress reduction; multimodality; neuroinflammation; noradrenergic; protein biomarkers; radioligand; recruit; relating to nervous system; respiratory; symptomatology; synergism; therapeutic target; vagus nerve stimulation

Project Summary/Abstract Migraine headaches represent the third most prevalent medical disorder on the planet, yet many sufferers are not satisfactorily treated, and 3% of them suffer chronification of their migraine every year. Cortical spreading depression and hyperexcitability of the brain have been demonstrated in migraine, and migraine pain has been related to neuroinflammation. In this project, we propose to use PET/MRI using a translocator protein marker (TSPO), as well as a measure of the infra-slow oscillatory activity to assess neuroinflammation in migraine. Then, we will examine the effect of a mind-body therapy on neuroinflammation. Our design will combine a top- down approach, namely mindfulness mediation, with a bottom-up approach, i.e. non-invasive transcutaneous vagus nerve stimulation, and examine the synergistic effect of these therapies on both microglial/astrocytic activation as measured with PET and on the fluctuation of low-frequency oscillatory activity. Our results will indicate whether a coupling of a top-down with a bottom-up therapeutic approach can have measurable effects on neuroinflammation in migraine, and indicate whether glial activation may be a therapeutic target for migraine.

项目总结/摘要 偏头痛是地球上第三大最常见的医学疾病，但许多患者 没有得到令人满意的治疗，其中3%的人每年都会患上偏头痛。皮层扩散性 在偏头痛中已经证实了大脑的抑郁和过度兴奋，并且偏头痛已经被 与神经炎症有关。在这个项目中，我们建议使用PET/MRI使用转运蛋白标记物 （TSPO），以及测量亚慢振荡活动以评估偏头痛中的神经炎症。 然后，我们将研究身心疗法对神经炎症的影响。我们的设计将结合联合收割机顶部- 向下的方法，即正念调解，与自下而上的方法，即非侵入性经皮 迷走神经刺激，并检查这些疗法对小胶质细胞/星形胶质细胞的协同作用。 激活，如用PET测量的和对低频振荡活动的波动。我们的结果将 表明自上而下与自下而上治疗方法的结合是否具有可测量的效果 偏头痛的神经炎症，并表明胶质细胞活化是否可能是治疗的目标， 偏头痛