Boosting mind-body mechanisms for mitigating neuroinflammation in migraine

项目摘要/摘要 偏头痛是地球上第三种最常见的疾病，但许多患者 没有得到满意的治疗，其中3%的人每年都会出现偏头痛的慢性化。皮质扩散 偏头痛表现出大脑的抑郁和过度兴奋，偏头痛 与神经炎有关。在这个项目中，我们建议使用使用转运蛋白标记的PET/MRI (TSPO)，以及一种衡量次慢振荡活动的指标，以评估偏头痛的神经炎症。 然后，我们将检查心身疗法对神经炎症的影响。我们的设计将结合上衣- 自下而上的方法，即正念调解，即无创经皮方法 迷走神经刺激，并检测这些疗法对小胶质细胞/星形胶质细胞的协同作用 用正电子发射计算机断层扫描(PET)测量的激活和低频振荡活动的波动。我们的结果将 指出自上而下和自下而上的治疗方法的结合是否具有可测量的效果 关于偏头痛的神经炎症，并表明神经胶质激活是否可能是治疗偏头痛的靶点 偏头痛。

Project Summary/Abstract Migraine headaches represent the third most prevalent medical disorder on the planet, yet many sufferers are not satisfactorily treated, and 3% of them suffer chronification of their migraine every year. Cortical spreading depression and hyperexcitability of the brain have been demonstrated in migraine, and migraine pain has been related to neuroinflammation. In this project, we propose to use PET/MRI using a translocator protein marker (TSPO), as well as a measure of the infra-slow oscillatory activity to assess neuroinflammation in migraine. Then, we will examine the effect of a mind-body therapy on neuroinflammation. Our design will combine a top- down approach, namely mindfulness mediation, with a bottom-up approach, i.e. non-invasive transcutaneous vagus nerve stimulation, and examine the synergistic effect of these therapies on both microglial/astrocytic activation as measured with PET and on the fluctuation of low-frequency oscillatory activity. Our results will indicate whether a coupling of a top-down with a bottom-up therapeutic approach can have measurable effects on neuroinflammation in migraine, and indicate whether glial activation may be a therapeutic target for migraine.