Defining the multivariate genomic signature of pubertal markers and impact on lifespan psychopathology
定义青春期标记的多变量基因组特征及其对寿命精神病理学的影响
基本信息
- 批准号:10641312
- 负责人:
- 金额:$ 16.97万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2023
- 资助国家:美国
- 起止时间:2023-09-01 至 2027-08-31
- 项目状态:未结题
- 来源:
- 关键词:AdolescenceAdolescentAdultAgeArchitectureAutomobile DrivingBehavioralBrainChildhoodComplexDataDevelopmentDimensionsEquationEstradiolEventFaceFemaleGeneticGenetic ModelsGenomeGenomic approachGenomicsGenotypeGrainGrowthHairHealthHormonalHumanIndividual DifferencesLifeLife Cycle StagesLinkLiteratureLongevityLongitudinal StudiesMeasuresMenarcheMental DepressionMental HealthMental disordersMethodsModelingMorbidity - disease rateNatureOutcomePathway interactionsPersonal SatisfactionPhenotypePrevalencePsychiatric DiagnosisPsychopathologyPubertyPublishingReportingResearchResearch PersonnelRiskRisk FactorsRisk TakingSamplingSex DifferencesSex DifferentiationSex Hormone-Binding GlobulinSignal TransductionSiteSourceStagingStructureSymptomsTestosteroneTimeTrainingVariantVoiceYouthcognitive developmentearly adolescencegenetic architecturegenetic associationgenome wide association studygenomic locusgenomic signatureimprovedinsightmalemortalitynon-geneticnovelphysical conditioningpsychiatric symptompubertal timingrate of changesexsexual dimorphismstatisticstooltrait
项目摘要
PROJECT SUMMARY/ABSTRACT
Adolescent increases in psychopathology across multiple dimensions have a significant detrimental impact on
morbidity, mortality and well-being during this period of life, and set the stage for adult physical and mental health
difficulties. Prevalence rates of internalizing psychopathology, which is higher on average in females, and
externalizing psychopathology, higher in males, diverge during adolescence, and this trajectory continues on
subsequently over the lifespan, implicating sex-differentiated mechanisms. Consistent with this, a robust
literature supports individual differences in pubertal timing (e.g., onset) and pubertal tempo (e.g., rate of change)
as risk-factors for increased psychopathology. However, reliance on single sex-specific indicators, retrospective
reports, and cross-sectional data to measure this dynamic period of maturation have made identification of
mechanisms driving puberty and psychopathology links difficult. The current study aims to capitalize on
measured genomics approaches integrated with longitudinal data in both sexes to inform the genomic signal of
puberty across multiple physical and hormonal indicators, and examine genetic covariation between puberty and
psychopathology across the lifespan. The first aim will leverage the novel method of genomic structural equation
modeling (genomic SEM; training aim 1) to combine summary statistics from published genome-wise association
studies (GWAS) of pubertal timing (i.e., age of menarche, relative age of voice break, relative age of first facial
hair), pubertal growth spurt, pubertal maturation (i.e., Tanner staging), testosterone, estradiol, and sex hormone
binding globulin (SHBG) to identify latent pubertal genomic factors both specific to and unified across sex.
Polygenic scores (PGS; training aim 2) derived from the multivariate pubertal genomic factors will be validated
by out-of-sample prediction of longitudinally measured pubertal timing and tempo characterized by multiple
pubertal markers in the Adolescent Brain Cognitive Development (ABCD) Study. The second aim is to investigate
measured genetic covariance of multivariate pubertal genomic signal with lifespan sex-differentiated
psychopathology (training aim 3). This will be achieved through (a) examining correlations between the pubertal
genomic factor model and previously established factor models of the genetic architecture of adult psychiatric
traits using genomic SEM, and estimating pubertal PGS prediction of sex-specific lifetime psychiatric diagnoses
in the UKBiobank; and (b) probing sex-specific and sex-unified pubertal PGS effects on longitudinally modeled
adolescent symptoms of psychopathology in the ABCD Study, both directly and in conjunction with longitudinally
measured pubertal timing and tempo. This research will yield a comprehensive model of measured genomic
signal of puberty across multiple related phenotypes in both sexes, and provide improved tools for parsing
genetic and non-genetic sources of covariation to disentangle multilayered mechanisms underlying pubertal risk
for psychopathology.
项目总结/文摘
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Megan Wales Patterson其他文献
Megan Wales Patterson的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
相似海外基金
Usefulness of a question prompt sheet for onco-fertility in adolescent and young adult patients under 25 years old.
问题提示表对于 25 岁以下青少年和年轻成年患者的肿瘤生育力的有用性。
- 批准号:
23K09542 - 财政年份:2023
- 资助金额:
$ 16.97万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
The impact of changes in social determinants of health on adolescent and young adult mental health during the COVID-19 pandemic: A longitudinal study of the Asenze cohort in South Africa
COVID-19 大流行期间健康社会决定因素的变化对青少年和年轻人心理健康的影响:南非 Asenze 队列的纵向研究
- 批准号:
10755168 - 财政年份:2023
- 资助金额:
$ 16.97万 - 项目类别:
A Priority Setting Partnership to Establish a Patient, Caregiver, and Clinician-identified Research Agenda for Adolescent and Young Adult Cancer in Canada
建立优先合作伙伴关系,以建立患者、护理人员和临床医生确定的加拿大青少年和年轻人癌症研究议程
- 批准号:
480840 - 财政年份:2023
- 资助金额:
$ 16.97万 - 项目类别:
Miscellaneous Programs
Incidence and Time on Onset of Cardiovascular Risk Factors and Cardiovascular Disease in Adult Survivors of Adolescent and Young Adult Cancer and Association with Exercise
青少年和青年癌症成年幸存者心血管危险因素和心血管疾病的发病率和时间以及与运动的关系
- 批准号:
10678157 - 财政年份:2023
- 资助金额:
$ 16.97万 - 项目类别:
Fertility experiences among ethnically diverse adolescent and young adult cancer survivors: A population-based study
不同种族青少年和年轻成年癌症幸存者的生育经历:一项基于人群的研究
- 批准号:
10744412 - 财政年份:2023
- 资助金额:
$ 16.97万 - 项目类别:
Treatment development for refractory leukemia using childhood/adolescent, and young adult leukemia biobank
利用儿童/青少年和青年白血病生物库开发难治性白血病的治疗方法
- 批准号:
23K07305 - 财政年份:2023
- 资助金额:
$ 16.97万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Molecular design of Two-Way Player CAR-T cells to overcome disease/antigen heterogeneity of childhood, adolescent, and young adult cancers
双向 CAR-T 细胞的分子设计,以克服儿童、青少年和年轻成人癌症的疾病/抗原异质性
- 批准号:
23H02874 - 财政年份:2023
- 资助金额:
$ 16.97万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Effects of adolescent social isolation on adult decision making and corticostriatal circuitry
青少年社会隔离对成人决策和皮质纹状体回路的影响
- 批准号:
10756652 - 财政年份:2023
- 资助金额:
$ 16.97万 - 项目类别:
Adolescent trauma produces enduring disruptions in sleep architecture that lead to increased risk for adult mental illness
青少年创伤会对睡眠结构产生持久的破坏,从而导致成人精神疾病的风险增加
- 批准号:
10730872 - 财政年份:2023
- 资助金额:
$ 16.97万 - 项目类别:
Using Tailored mHealth Strategies to Promote Weight Management among Adolescent and Young Adult Cancer Survivors
使用量身定制的移动健康策略促进青少年和年轻癌症幸存者的体重管理
- 批准号:
10650648 - 财政年份:2023
- 资助金额:
$ 16.97万 - 项目类别: