Functions of the Cortical Amygdala in social behavior

皮质杏仁核在社会行为中的功能

• 批准号: 10641270
• 负责人: Antonio V Aubry
• 金额: $ 13.69万
• 依托单位: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-04-01 至 2025-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10641270
• 关键词: Adaptive Behaviors; Affect; Aggressive behavior; Amygdaloid structure; Anger; Animals; Anogenital region; Axon; Behavior; Behavior Control; Behavioral; Brain region; Cells; Child Rearing; Complex; Corpus striatum structure; Cues; Data; ESR1 gene; Economic Burden; Ensure; Exhibits; Face; Female; Fiber; Fire - disasters; Food; Globus Pallidus; Home; Human; Hypothalamic structure; Image; Impairment; Individual; Individual Differences; Investigation; Lateral; Learning; Link; Mediating; Mental disorders; Modeling; Motivation; Mouse Strains; Mus; Odors; Partner in relationship; Pathologic; Perception; Perforation; Phase; Photometry; Play; Population; Process; Research; Research Personnel; Resources; Risk; Rodent; Role; Self Administration; Sensory; Signal Transduction; Slice; Smell Perception; Social Behavior; Social Environment; Social Hierarchy; Social Perception; Social Protection; Societies; Stimulus; Structure; System; Testing; Training; Ventral Striatum; Vision; Visual System; Whole-Cell Recordings; Work; behavioral response; cell type; diencephalon; in vivo; male; motivational processes; neuromechanism; nonhuman primate; olfactory bulb; olfactory stimulus; optogenetics; prevent; programs; response; sensory input; social

Project Summary Aggression is an evolutionarily conserved behavior that controls social hierarchies and protects valuable resources like mates, food, and territory. In most cases, aggression is a necessary, adaptive component of social behavior. In humans, however, some forms of aggression are considered pathological when they threaten lives, increase the risk of psychiatric impairment in victims, and incur economic burdens on society. Considerable evidence indicates that aggression is associated with aberrant facial perception in humans. Physically aggressive individuals have a tendency to identify ambiguous faces as threatening or angry. This suggests that these individuals have a perceptual bias which impairs the ability of the individual to interpret the level of threat correctly. There is ample evidence in human and non-human primates that the amygdala plays a key role in social perception. Studies with human and non-human primates examining the amygdala's role in social perception have focused on the lateral and basolateral amygdala given their extensive connections with the visual system and because they are a highly dependent on vision. Conversely, rodents are more reliant on olfaction, and thus, we need a deeper understanding of amygdala interactions with olfactory structures during social encounters. The posterior cortical amygdala (COAp) is one such region which receives input from olfactory structures. Our preliminary data suggest that activation of ESR-1 cells in the COAp are necessary for aggressive behavior to occur in males but not females. Furthermore, these cells show an increase in activity during attack behavior in males. In addition to the expected input from the main olfactory bulb, we discovered that this cell population also receives input from the ventral striatopallidal system, which is involved in motivational processes. For the K99 phase of this proposal, I will test the hypothesis that the ventral striatopallidal system affects the motivation to attack by modulating preparatory activity in the COAp. Over the R00 phase, I will build a research program to test the hypothesis that the COAp mediates state-dependent responses to social olfactory stimuli. In order to induce an “aggressive state” in mice we will use the social instigation model. The results from this proposal will increase the field's understanding of how non-sensory variables affect what are traditionally known as sensory regions. In addition, the proposed training will allow me to develop a future research program geared towards identifying mechanisms underlying the effects of altered behavioral states on perceptual processes.

项目摘要 攻击是一种进化保守的行为，它控制着社会等级，保护着有价值的 比如配偶食物和领土在大多数情况下，攻击性是一个必要的，适应性的组成部分， 社会行为然而，在人类中，某些形式的攻击被认为是病态的，当他们 威胁生命，增加受害者精神损害的风险，并给社会带来经济负担。 相当多的证据表明，攻击性与人类异常的面部知觉有关。 身体攻击性的人倾向于将模糊的面孔识别为威胁或愤怒。这 这表明，这些人有一个感性的偏见，损害了个人的能力，以解释 正确的威胁程度。在人类和非人类灵长类动物中有充分的证据表明，杏仁核起着重要的作用。 在社会认知中的关键作用。对人类和非人类灵长类动物进行的研究， 社会知觉集中在外侧和基底外侧杏仁核上，因为它们与 视觉系统，因为它们高度依赖于视觉。相反，啮齿类动物更依赖于 因此，我们需要更深入地了解杏仁核与嗅觉结构的相互作用， 社交活动后皮质杏仁核（COAp）就是这样一个区域， 嗅觉结构我们的初步数据表明，COAp中ESR-1细胞的激活是必要的， 攻击性行为只发生在雄性而不是雌性。此外，这些细胞显示出活性增加， 在雄性的攻击行为中。除了来自主嗅球的预期输入，我们发现 这个细胞群也接受来自腹侧纹状体系统的输入，该系统参与了 激励过程。对于K99阶段的这个建议，我将测试的假设，腹 纹状体苍白球系统通过调节COAp中的准备活动来影响攻击动机。来 R 00阶段，我将建立一个研究计划，以测试的假设，COAp介导的状态依赖 对社会嗅觉刺激的反应。为了在小鼠中诱导“攻击性状态”，我们将使用社交网络。 煽动模式。这项提议的结果将增加该领域对非感官如何影响 变量影响传统上被称为感觉区域的东西。另外，建议中的培训将使我 开发一个未来的研究计划，旨在确定改变的影响的潜在机制， 行为状态对知觉过程的影响