Cortical processing of three-dimensional object-motion

三维物体运动的皮层处理

基本信息

  • 批准号:
    10638729
  • 负责人:
  • 金额:
    $ 43.59万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2023
  • 资助国家:
    美国
  • 起止时间:
    2023-07-01 至 2028-03-31
  • 项目状态:
    未结题

项目摘要

PROJECT SUMMARY/ABSTRACT How do we perceive the three-dimensional (3D) movement of objects in the world when our eyes only sense two-dimensional (2D) projections like a movie on a screen? Accurate and precise perception of 3D object motion is essential to intercept objects (e.g., catch a ball) and evade others (e.g., dodge a passing bicyclist). The goal of this proposal is to elucidate the cortical networks that transform ambiguous 2D retinal signals into high-level 3D object-motion representations. To achieve this goal, we will utilize a synergistic combination of behavioral, electrophysiological, and causal manipulation approaches with macaque monkeys. In Aim 1, we will distinguish 2D retinal motion selectivity from 3D object-motion selectivity at the single neuron level and evaluate functional correlations with behavior. We will test the hypothesis that 3D object-motion representations are created within a cortical network consisting of the middle temporal area (MT), the fundus of the superior temporal sulcus (FST), and the lateral subdivision of the medial superior temporal sulcus (MSTl). The experiments will combine a 3D object-motion discrimination task with simultaneous high-density neuronal recordings from all three areas. Importantly, the stimulus set was rigorously vetted through previous perceptual and computational studies, and maximally discriminates 2D retinal vs. 3D object-motion representations. This work will be the first to assess functional correlations between neuronal activity and the behavioral discrimination of 3D object-motion. To evaluate the cortical network organization of MT, FST, and MSTl, we will compare the areas’ functional properties and measure the Granger causal influences between them using simultaneously recorded local field potentials. In Aim 2, we will apply a complementary approach to assess the causal contributions of each area to 3D motion perception. Specifically, we will use electrical microstimulation (EM) with weak currents to manipulate neuronal activity while the monkeys perform the 3D object-motion discrimination task. These experiments will be the first to use EM to causally probe the relationship between neuronal activity and 3D object-motion perception. Critically, the predicted relationship between neuronal response properties at the site of EM and the induced behavioral biases depends on whether the stimulated neurons are either: (i) selective for 2D retinal motion (with outputs that are used by downstream neurons to compute 3D object-motion, otherwise no effect of EM would be expected) or (ii) selective for 3D object-motion. We will test the predictions locally (i.e., at the level of individual neurons within each area) to assess area-specific functional heterogeneity and globally (i.e., between areas) to assess hierarchical differences across the network. The proposed experiments will together explicate differences in the functional properties of three interconnected cortical areas as well as their causal contributions to 3D motion perception. By elucidating the cortical networks that transform 2D retinal signals into ecologically relevant representations of 3D object-motion, insights from this work will facilitate future studies that explore how neuronal representations of dynamic, object-level information support interactions with the 3D world.
项目总结/文摘

项目成果

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Ari Rosenberg其他文献

Ari Rosenberg的其他文献

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{{ truncateString('Ari Rosenberg', 18)}}的其他基金

Neuroscience Training Program
神经科学培训计划
  • 批准号:
    10413951
  • 财政年份:
    2019
  • 资助金额:
    $ 43.59万
  • 项目类别:
Neuroscience Training Program
神经科学培训计划
  • 批准号:
    10189717
  • 财政年份:
    2019
  • 资助金额:
    $ 43.59万
  • 项目类别:
Neuroscience Training Program
神经科学培训计划
  • 批准号:
    10665637
  • 财政年份:
    2019
  • 资助金额:
    $ 43.59万
  • 项目类别:
Hierarchical cortical circuits implementing robust 3D visual perception
分层皮质电路实现强大的 3D 视觉感知
  • 批准号:
    10468723
  • 财政年份:
    2018
  • 资助金额:
    $ 43.59万
  • 项目类别:
Hierarchical cortical circuits implementing robust 3D visual perception
分层皮质电路实现强大的 3D 视觉感知
  • 批准号:
    9769032
  • 财政年份:
    2018
  • 资助金额:
    $ 43.59万
  • 项目类别:
Hierarchical cortical circuits implementing robust 3D visual perception
分层皮质电路实现强大的 3D 视觉感知
  • 批准号:
    10237226
  • 财政年份:
    2018
  • 资助金额:
    $ 43.59万
  • 项目类别:
Vestibular contribution to the encoding of object orientation relative to gravity
前庭对相对于重力的物体方向编码的贡献
  • 批准号:
    9174035
  • 财政年份:
    2014
  • 资助金额:
    $ 43.59万
  • 项目类别:

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