Aboriginal Birth Cohort Study: from childhood to adulthood.

原住民出生队列研究：从童年到成年。

• 批准号: nhmrc : 436011
• 负责人: A/Pr Gurmeet Singh
• 金额: $ 33.69万
• 依托单位: Menzies School of Health Research
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2007
• 资助国家: 澳大利亚
• 起止时间: 2007-01-01 至 2009-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/aboriginal-birth-cohort-childhood-adulthood/76610
• 关键词: Aboriginal; Birth; Cohort; Study; childhood

Aboriginal peoples have poor health at both ends of their life span. There are more low birth weight babies at the beginning and more kidney, heart disease and diabetes at the end of the life spectrum. The Aboriginal Birth Cohort study aims to examine the effect of early life events (such as low birth weight) on the risk of developing chronic disease in later life with a view to early intervention. The babies of the study were last seen at 11 years and are now being seen again near their 18th birthday. Data available are weight, length and gestational age of these babies at birth, the health and lifestyle of their mothers during pregnancy and the children's growth and health. By 11 years of age, the low birth babies still remained shorter and thinner than their peers who were normal size at birth, but importantly, markers of chronic disease were not higher in these children. The current round of investigation, in addition to the tests done before, now includes non-invasive markers of heart disease, such as heart rate variability, measures of arterial stiffness and the thickness of carotid intima media (lining) and a dental examination looking at both teeth and gums. For the first time, the study will look beyond the physical to examine the psychological wellbeing of these young adults using a specially designed questionnaire (Strong souls). Little is known about this age group because they are relatively healthy and do not present to clinics for treatment. The continuing life course study of this cohort, forming the oldest and largest birth cohort of any indigenous population in the world, will help us understand the relationships between early life and the sequential events that lead to chronic adult disease. This will help determine the most effective time for intervention programmes, and will influence public health planning and policy directed towards the improvement of the health of Aboriginal peoples.

土著人在生命的两端健康状况都很差。在生命的开始阶段，有更多的低出生体重婴儿，在生命的结束阶段，有更多的肾病、心脏病和糖尿病。土著出生队列研究的目的是审查生命早期事件（如出生体重低）对晚年患慢性病风险的影响，以便及早干预。这项研究的婴儿最后一次被看到是在11岁，现在又在18岁生日附近被看到。现有的数据包括这些婴儿出生时的体重、身长和胎龄、母亲怀孕期间的健康和生活方式以及儿童的成长和健康。到11岁时，低出生率的婴儿仍然比出生时正常尺寸的同龄人更矮更瘦，但重要的是，这些儿童的慢性疾病标志物并不高。目前这一轮的调查，除了之前做的测试外，现在还包括心脏病的非侵入性标志物，如心率变异性，动脉硬度和颈动脉内膜中层厚度的测量，以及牙齿和牙龈的牙科检查。这项研究将首次超越身体，使用专门设计的问卷（坚强的灵魂）来检查这些年轻人的心理健康。对这个年龄组的人知之甚少，因为他们相对健康，不去诊所接受治疗。对这一组人的生命历程进行持续研究，将有助于我们了解生命早期与导致慢性成人疾病的连续事件之间的关系，这一组人是世界上任何土著人口中年龄最大的出生组人。这将有助于确定干预方案的最有效时间，并将影响旨在改善土著人民健康的公共卫生规划和政策。