Aboriginal Birth Cohort Study: from childhood to adulthood.

原住民出生队列研究：从童年到成年。

• 批准号: nhmrc : 436011
• 负责人: A/Pr Gurmeet Singh
• 金额: $ 33.69万
• 依托单位: Menzies School of Health Research
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2007
• 资助国家: 澳大利亚
• 起止时间: 2007-01-01 至 2009-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/aboriginal-birth-cohort-childhood-adulthood/76610
• 关键词: Aboriginal; Birth; Cohort; Study; childhood

Aboriginal peoples have poor health at both ends of their life span. There are more low birth weight babies at the beginning and more kidney, heart disease and diabetes at the end of the life spectrum. The Aboriginal Birth Cohort study aims to examine the effect of early life events (such as low birth weight) on the risk of developing chronic disease in later life with a view to early intervention. The babies of the study were last seen at 11 years and are now being seen again near their 18th birthday. Data available are weight, length and gestational age of these babies at birth, the health and lifestyle of their mothers during pregnancy and the children's growth and health. By 11 years of age, the low birth babies still remained shorter and thinner than their peers who were normal size at birth, but importantly, markers of chronic disease were not higher in these children. The current round of investigation, in addition to the tests done before, now includes non-invasive markers of heart disease, such as heart rate variability, measures of arterial stiffness and the thickness of carotid intima media (lining) and a dental examination looking at both teeth and gums. For the first time, the study will look beyond the physical to examine the psychological wellbeing of these young adults using a specially designed questionnaire (Strong souls). Little is known about this age group because they are relatively healthy and do not present to clinics for treatment. The continuing life course study of this cohort, forming the oldest and largest birth cohort of any indigenous population in the world, will help us understand the relationships between early life and the sequential events that lead to chronic adult disease. This will help determine the most effective time for intervention programmes, and will influence public health planning and policy directed towards the improvement of the health of Aboriginal peoples.

原住民在生命的两端健康状况不佳。早期的低出生体重婴儿较多，而生命谱末期的肾病、心脏病和糖尿病患者则较多。原住民出生队列研究旨在研究早期生活事件（例如低出生体重）对晚年患慢性病风险的影响，以期进行早期干预。该研究中的婴儿最后一次被看到是在 11 岁的时候，现在再次被看到是在他们 18 岁生日附近。现有数据包括这些婴儿出生时的体重、身长和孕龄、母亲在怀孕期间的健康和生活方式以及孩子的成长和健康。到了 11 岁时，低出生婴儿仍然比出生时正常体型的同龄人更矮、更瘦，但重要的是，这些孩子的慢性病标志物并不更高。除了之前进行的测试外，本轮的调查现在还包括心脏病的非侵入性标志物，例如心率变异性、动脉硬度测量和颈动脉内膜中层厚度以及对牙齿和牙龈的牙科检查。该研究首次使用专门设计的问卷（坚强的灵魂），超越身体健康，考察这些年轻人的心理健康状况。人们对这个年龄组知之甚少，因为他们相对健康，不会到诊所接受治疗。对这个队列的持续生命历程研究，形成了世界上任何土著人口中最古老和最大的出生队列，将帮助我们了解早期生命与导致慢性成人疾病的连续事件之间的关系。这将有助于确定干预计划的最有效时间，并将影响旨在改善原住民健康的公共卫生规划和政策。