MRC National Survey of Health and Development (NSHD, 1946 British Birth Cohort).

研究背景目前有920万人，占英国人口的14%，年龄在70岁以上；这一数字在未来十年将迅速增长。预期寿命的增长停滞不前，健康状况不佳的年数增加了。痴呆症是导致老年依赖的重要因素，已超过心血管疾病成为最常见的死亡原因。这些趋势将大大增加本已捉襟见肘的卫生和社会护理服务的压力。迫切需要研究找到改善终生健康老龄化的方法。1946年共有5362名新生儿出生的MRC NSHD被描述为队列皇冠上的明珠；它是世界上持续时间最长的出生队列，也是英国国家出生队列中年龄最大的。它处于独特的位置，可以满足MRC关于“促进健康老龄化和减少一生中精神和身体疾病的负担”的战略交付计划，UKRI的战略主题“确保更好的健康，老龄化和福祉”，以及PRUK最大限度地发挥数据潜力的范围。超过2500名参与者进行了跟踪调查，从27次扫描中，我们进行了广泛的生物医学、社会经济、认知和身体测量。储存血液、尿液、唾液和脑脊液等生物样本。重复的大脑和心脏成像&在获得器官捐赠持续同意的情况下，老年人获得了长期的可穿戴和远程数据。这些复杂多样的数据的处理、存储、发现和访问基础设施将确保这一宝贵资源的长期遗产。参与者称自己为道格拉斯儿童，以NSHD的创始人詹姆斯·道格拉斯的名字命名，反映了他们对这项研究的毕生承诺。这反映在对正在进行的数据收集的持续高回复率(70%-80%)，其中包括问卷调查、密集的临床亚研究、腰椎穿刺术(30%)和器官捐赠(30%)。这些异常高的应答率可以与年轻队列中低得多的应答率形成对比。伦敦大学学院纵向研究中心(CLS)负责策划所有连续的国家出生队列(1958、1970和2000)。我们与CLS的合作将统一数据流程和访问合并的全国出生队列资源。目的：我们将显著增加对NSHD数据资源的多学科使用，以了解和通报整个生命周期的健康和福祉。为了实现这一目标，我们将提高丰富的整个生命数据的可见性和访问权限，通过国家记录链接来加强这一点，并确保持续参与研究。目标使NSHD数据与健康和管理记录相关联。加快复杂和重复的可穿戴式、远程测试、多组学和成像数据的使用。确保77年的历史和正在进行的数据满足数据和生物样本的最佳当前实践标准，以及广泛的多学科研究人员的可发现性、访问性和可用性。与CLS建立所有国家出生队列数据的单一“前门”，建立共同的数据流程，并加快生物医学和社会科学社区对所有5个国家出生队列数据的使用。保持参与者参与度。测试低强度数据收集的不同方法，为未来的拨款申请提供信息。应用和好处加快跨多个学科的独特NSHD资源的使用通过链接，支持临床结果研究工具生成工具，从复杂的可穿戴、远程、成像和多组体数据中提取可供分析的变量更大程度地部署所有国家出生队列，以解决政策问题所有国家出生队列的新数据收集的一致性为更年轻的国家出生队列中更多的生物医学数据收集奠定了基础对成年高峰期健康发展、中年维持和成功老龄化的新见解。

Research contextCurrently 9.2 million people, 14% of the UK population, are aged over 70; these numbers will grow rapidly over the next decade. Increases in life expectancy have stalled, and number of years lived in poor health has increased. Dementia, a significant contributor to old age dependency, has overtaken cardiovascular disease as the commonest cause of death. These trends will substantially increase pressure on already stretched health and social care services. Research is urgently needed to find ways of improving healthy ageing throughout life. The MRC NSHD of 5362 births in 1946 is described as the 'jewel in the crown' of cohorts; it is the longest continually running birth cohort in the world and the oldest of the UK national birth cohorts. It is uniquely placed to address the MRC Strategic Delivery Plan on "promoting healthy ageing & reducing the burden of mental and physical illness throughout life", the UKRI strategic theme of "securing better health, ageing & wellbeing" and PRUK's scope to maximise data potential. Over 2500 participants are in follow up, from 27 sweeps we have extensive biomedical, socioeconomic, cognitive, and physical measures. Biological samples such as blood, urine, saliva and CSF are stored. Repeat brain and cardiac imaging & long term wearable and remote data have been acquired in older age, with ongoing consent for organ donation. Processing, storage, discovery and access infrastructures for these diverse and complex data will secure the long-term legacy of this precious resource. Participants refer to themselves as the 'Douglas children', named after James Douglas who founded the NSHD, reflecting their lifelong commitment to the study. This is reflected by consistently high response rates to on-going data collections (70-80%) which include questionnaires, intensive clinical sub-studies, lumbar puncture (30%), & organ donation (30%). These exceptionally high responses rates can be contrasted with the much lower response rates in the younger cohorts.The Centre for Longitudinal Studies (CLS) at UCL curates all successive national birth cohorts (1958, 1970 and 2000). Our alignment with CLS will unify data processes and access to the combined national birth cohort resource. AimsWe will markedly increase the multidisciplinary use of the NSHD data resource to understand and inform on health and wellbeing throughout life. To achieve this we will improve visibility of and access to the rich whole of life data, enhance this with national record linkage and ensure continued participant engagement with research.ObjectivesTo enable linkage of NSHD data to health and administrative records.To accelerate use of complex and repeat wearable, remote testing, multi-omic and imaging data.To ensure the 77 years' of historical and ongoing data meet best current standards of practice for data and biosample discoverability, access and usability by a broad base of multidisciplinary researchers. To establish a single 'front door' to all national birth cohort data with the CLS, establishing common data processes and accelerating use of all 5 national birth cohorts by the biomedical and social science community. To maintain participant engagement.To test out different ways of low intensity data collection to inform future grant applications.Applications and benefitsAccelerate the use of the unique NSHD resource across multiple disciplinesWith linkage, enable study of clinical outcomes Generation of tools to extract analysis-ready variables from complex wearable, remote, imaging and multi-omic dataGreater deployment of all national birth cohorts together to address policy questions Alignment of new data collection across all national birth cohorts Set the foundation for greater biomedical data collection in the younger national birth cohortsNovel insights into the development of peak health adulthood, maintenance in middle age and successful ageing.