MRC National Survey of Health and Development (NSHD, 1946 British Birth Cohort).

MRC 国家健康与发展调查（NSHD，1946 年英国出生队列）。

• 批准号: MR/Y014022/1
• 负责人: Nishi Chaturvedi
• 金额: $ 271.51万
• 依托单位: University College London
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2024
• 资助国家: 英国
• 起止时间: 2024 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=MR%2FY014022%2F1
• 关键词: MRC; National; Survey; Health; Development

Research contextCurrently 9.2 million people, 14% of the UK population, are aged over 70; these numbers will grow rapidly over the next decade. Increases in life expectancy have stalled, and number of years lived in poor health has increased. Dementia, a significant contributor to old age dependency, has overtaken cardiovascular disease as the commonest cause of death. These trends will substantially increase pressure on already stretched health and social care services. Research is urgently needed to find ways of improving healthy ageing throughout life. The MRC NSHD of 5362 births in 1946 is described as the 'jewel in the crown' of cohorts; it is the longest continually running birth cohort in the world and the oldest of the UK national birth cohorts. It is uniquely placed to address the MRC Strategic Delivery Plan on "promoting healthy ageing & reducing the burden of mental and physical illness throughout life", the UKRI strategic theme of "securing better health, ageing & wellbeing" and PRUK's scope to maximise data potential. Over 2500 participants are in follow up, from 27 sweeps we have extensive biomedical, socioeconomic, cognitive, and physical measures. Biological samples such as blood, urine, saliva and CSF are stored. Repeat brain and cardiac imaging & long term wearable and remote data have been acquired in older age, with ongoing consent for organ donation. Processing, storage, discovery and access infrastructures for these diverse and complex data will secure the long-term legacy of this precious resource. Participants refer to themselves as the 'Douglas children', named after James Douglas who founded the NSHD, reflecting their lifelong commitment to the study. This is reflected by consistently high response rates to on-going data collections (70-80%) which include questionnaires, intensive clinical sub-studies, lumbar puncture (30%), & organ donation (30%). These exceptionally high responses rates can be contrasted with the much lower response rates in the younger cohorts.The Centre for Longitudinal Studies (CLS) at UCL curates all successive national birth cohorts (1958, 1970 and 2000). Our alignment with CLS will unify data processes and access to the combined national birth cohort resource. AimsWe will markedly increase the multidisciplinary use of the NSHD data resource to understand and inform on health and wellbeing throughout life. To achieve this we will improve visibility of and access to the rich whole of life data, enhance this with national record linkage and ensure continued participant engagement with research.ObjectivesTo enable linkage of NSHD data to health and administrative records.To accelerate use of complex and repeat wearable, remote testing, multi-omic and imaging data.To ensure the 77 years' of historical and ongoing data meet best current standards of practice for data and biosample discoverability, access and usability by a broad base of multidisciplinary researchers. To establish a single 'front door' to all national birth cohort data with the CLS, establishing common data processes and accelerating use of all 5 national birth cohorts by the biomedical and social science community. To maintain participant engagement.To test out different ways of low intensity data collection to inform future grant applications.Applications and benefitsAccelerate the use of the unique NSHD resource across multiple disciplinesWith linkage, enable study of clinical outcomes Generation of tools to extract analysis-ready variables from complex wearable, remote, imaging and multi-omic dataGreater deployment of all national birth cohorts together to address policy questions Alignment of new data collection across all national birth cohorts Set the foundation for greater biomedical data collection in the younger national birth cohortsNovel insights into the development of peak health adulthood, maintenance in middle age and successful ageing.

研究环境尚不在920万人，占英国人口的14％，年龄在70岁以上；这些数字将在未来十年迅速增长。预期寿命的增加已经停滞不前，健康状况不佳的年限增加了。痴呆症是老年依赖性的重要贡献者，已超过心血管疾病，是最常见的死亡原因。这些趋势将大大增加对已经伸展的健康和社会护理服务的压力。迫切需要进行研究以找到改善一生健康衰老的方法。 1946年5362个出生的MRC NSHD被描述为“皇冠上的珠宝”。它是世界上最长的持续出生队列，也是英国国民出生队列中最古老的人群。旨在解决MRC战略交付计划的独特之处，该计划“促进健康的衰老并减轻一生的精神和身体疾病负担”，这是“确保更好的健康，衰老和福祉”以及PRUK的范围，以最大程度地提高数据潜力。超过2500名参与者正在随访中，从27个扫描中，我们拥有广泛的生物医学，社会经济，认知和身体措施。存储了血液，尿液，唾液和CSF等生物样品。在持续同意器官捐赠的同意下，重复的大脑和心脏成像以及长期可穿戴和远程数据已获得。这些多样化和复杂数据的处理，存储，发现和访问基础架构将确保此宝贵资源的长期遗产。参与者将自己称为“道格拉斯儿童”，以创立NSHD的詹姆斯·道格拉斯（James Douglas）的名字命名，反映了他们对这项研究的终身承诺。对正在进行的数据收集（70-80％）的响应率始终高，包括问卷，密集临床子研究，腰椎穿刺（30％）和器官捐赠（30％）。这些异常高的反应率可以与年轻同伙的反应率较低。UCL的纵向研究中心（CLS）策划了所有连续的民族出生人群（1958年，1970年和2000年）。我们与CLS的一致性将统一数据过程并访问联合国家出生队列资源。 AIMSWE将明显增加NSHD数据资源的多学科使用，以了解和了解一生的健康和福祉。为了实现这一目标，我们将提高对丰富整个生活数据的可见性和获取性，通过国家记录联系来增强这一点，并确保参与者参与研究。Objectivesto可以将NSHD数据与健康和行政记录联系起来。以加速复杂，重复可穿戴，远程测试，多态和成像的典范，以确保访问77年的历史性数据，以确保当前的数据访问的目前，该数据的访问量很高。多学科研究人员的广泛基础。为了建立与CLS的所有国家出生队列数据的单一“前门”，建立了共同的数据过程，并加速了生物医学和社会科学界对所有5个国家出生队列的使用。维持参与者的参与。要测试不同的低强度数据收集方式，以告知未来的赠款应用程序。与链接相关的多个学科中独特的NSHD资源的使用和福利，可以研究临床结果，从而生成工具，从在年轻的国家出生队列诺维尔（Cohortsnovel）的洞察力中，为大量的生物医学数据收集奠定了基础，以洞察成年峰值的发展，中年维护和成功衰老。