Multimodal Neuroimaging Predictors of Non-Suicidal Self-Injury in the ABCD Study

ABCD 研究中非自杀性自伤的多模态神经影像预测因子

• 批准号: 10639048
• 负责人: Lisanne Michelle Jenkins
• 金额: $ 41.33万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-05-01 至 2028-02-29
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10639048
• 关键词: Adolescence; Adolescent; Age; Age of Onset; Amygdaloid structure; Back; Behavior; Biological; Brain; Brain region; Clinical; Communities; Complex; Cross-Sectional Studies; Data; Data Set; Development; Diffusion; Emotional; Emotions; Environmental Risk Factor; Face; Family history of; Feeling suicidal; Female; Functional Magnetic Resonance Imaging; Functional disorder; Future; Image; Individual; Informal Social Control; Insula of Reil; Intervention; Investigational Therapies; Magnetic Resonance Imaging; Measures; Mental Depression; Methods; Prevalence; Prevention strategy; Psychophysiology; Recording of previous events; Reporting; Research; Rest; Risk; Risk Factors; Sample Size; Sampling; Schools; Sex Differences; Shapes; Signal Transduction; Social Environment; Social Interaction; Structural defect; Structure; Suicide attempt; Therapeutic; Thick; Thinness; Time; Tissues; Youth; aged; brain abnormalities; brain dysfunction; cognitive control; cognitive development; comparison control; emotion regulation; improved; inclusion criteria; loved ones; male; maternal depression; multimodal neuroimaging; multimodality; neuroimaging; neuroregulation; non-suicidal self injury; novel; parental influence; pharmacologic; prevent; protective factors; psychologic; recruit; response; school environment; social exclusion; suicidal; suicidal morbidity; support network; therapy development; white matter

PROJECT SUMMARY ABSTRACT Non-suicidal self-injury (NSSI), the deliberate destruction of one’s own body tissue without suicidal intent, is alarmingly common in adolescents, and a risk factor for suicide attempts and deaths. NSSI typically emerges in adolescence, when brain networks supporting self-regulation, such as the cognitive control network, are still maturing, thus dysfunctional brain networks may underlie NSSI risk in adolescents. This project will leverage data from the Adolescent Brain Cognitive Development (ABCD) Study, including baseline MRI data collected when youth are aged 9-10 years, to identify brain network abnormalities in youth who develop NSSI two or more years later. Our analyses will be performed on multimodal MRI data and focus on two major intrinsic functional brain networks. These are the salience network, involved in emotion, and implicated in previous studies of NSSI, and the cognitive control network, important for emotion regulation, yet less comprehensively studied in NSSI. Our central hypothesis is that youth who develop NSSI have enhanced activity and integrity of the salience network and reduced activity and integrity of the cognitive control network compared to a sample of individually matched controls without NSSI. We propose a cross-sectional analysis of MRI data from baseline, in youth who develop NSSI for the first time (and with no history of suicidal ideation or attempt) at year 2 or later. At Year 2, N=141 (68 males) youths met our NSSI criteria. The number of males means this will be the first neuroimaging study with sufficient males to analyze sex differences. Based on community prevalence, we conservatively estimate that 560 youth will meet our NSSI group inclusion criteria by Year 6 (R01 Year 3), for a total sample size of 1120. Aim 1 will investigate fMRI tasks that measure salience network (an emotional N-back task) and cognitive control network (a Stop Signal task) function. We will also study connectivity of these networks during different task conditions using psychophysiological interaction analysis. Aim 2 will investigate the structural integrity of the salience and cognitive control networks by analyzing diffusion imaging to study white matter, and T1-weighted MRI to measure cortical thickness and amygdala shape and volume. Aim 3 will investigate the potential modifying influence of parental history of depression and of school environmental factors on the relationship between brain structure and function, and NSSI risk. An exploratory sub-aim will identify whether earlier age of onset of NSSI is associated with stronger network effects on risk for NSSI. By studying brain networks prior to NSSI onset, this study has promise for identifying biological targets that could be used in experimental therapeutics treatment development, such as pharmacological or neuromodulatory therapeutics. These could reduce the harmful physical and psychological effects of NSSI on individuals and their loved ones, and prevent future deaths by suicide.

项目摘要 非自杀性自伤（NSSI），故意破坏自己的身体组织没有自杀的意图，是 在青少年中非常常见，是自杀企图和死亡的危险因素。NSSI通常出现在 在青春期，当支持自我调节的大脑网络，如认知控制网络， 然而，大脑网络仍在发育成熟，因此，功能失调的大脑网络可能是青少年NSSI风险的基础。该项目将 利用青少年大脑认知发展（ABCD）研究的数据，包括基线MRI数据 当青少年年龄在9 - 10岁时收集，以确定青少年大脑网络异常， 两年后的NSSI。我们的分析将在多模态MRI数据上进行，重点关注两个 主要的内在脑功能网络。这些是突显网络，涉及情感， 在以前的研究中，NSSI和认知控制网络对情绪调节很重要，但较少 在NSSI中进行了全面的研究。我们的中心假设是，发展NSSI的年轻人 活动和完整性的显着性网络和减少活动和完整性的认知控制 网络与没有NSSI的单独匹配对照样本进行比较。我们提出了一个横截面 分析首次发生NSSI的年轻人（并且没有病史）基线MRI数据 自杀意念或企图）。在第二年，N = 141（68名男性）青年符合我们的NSSI标准。 男性的数量意味着这将是第一个有足够男性来分析性别的神经成像研究 差异根据社区患病率，我们保守估计，560名青少年将符合我们的NSSI 按第6年（R01第3年）分组入选标准，总样本量为1120。目标1将研究功能磁共振成像 测量显着性网络（情绪N-back任务）和认知控制网络（停止）的任务 信号任务）功能。我们还将研究这些网络在不同任务条件下的连通性， 心理生理互动分析目标2将研究结构的完整性， 认知控制网络，通过分析扩散成像来研究白色物质，以及T1加权MRI来 测量皮质厚度和杏仁核形状和体积。目标3将研究潜在的修改 父母抑郁史和学校环境因素对抑郁症与抑郁症关系的影响 大脑结构和功能，以及NSSI风险。一个探索性的子目标将确定是否较早的发病年龄 的NSSI与更强的网络效应对风险的NSSI。通过研究大脑网络， NSSI发作，这项研究有希望确定生物靶点，可用于实验 治疗剂治疗开发，如药理学或神经调节治疗剂。这些 可以减少NSSI对个人及其亲人的有害身心影响， 防止未来的自杀。