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The Impact of Pharmaceutical Industry Messaging on the Opioid Crisis among U.S. Military Veterans

制药行业信息对美国退伍军人阿片类药物危机的影响

基本信息

批准号：
10640028
负责人：
Luther Elliott
金额：
$ 67.2万
依托单位：
NDRI-USA, INC.
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-05-01 至 2028-02-28
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10640028
关键词：
Addendum Advocacy Anxiety Disorders Archives Area Attitude Automobile Driving Back Benzodiazepines Black race Caring Case Study Cessation of life Circulation Clinical Cognitive County Data Data Set Development Disadvantaged Disparity Documentation Dose Drug Controls Drug Industry Ethnic Origin Formulation Fostering HIV/HCV Health Healthcare Systems Hepatitis C Heroin Hospitals Industry Injections Injury Intervention Interview Journals Label Leadership Legal Literature Litigation Low income Manufacturer Marketing Medical Methodology Methods Military Personnel Minority Morbidity - disease rate Natural History Newspapers Opioid Opioid Analgesics Outcome Overdose Pain Pain management Patients Perception Periodicals Pharmaceutical Preparations Pharmacologic Substance Phase Policies Policy Maker Population Prevalence Process Public Health Publications Publishing Race Recording of previous events Research Research Methodology Research Personnel Resources Risk Role Scholarship Scientist Shapes Sleep Disorders Technology Tobacco Tobacco Industry Translating Translational Research United States Department of Veterans Affairs Veterans Veterans Health Administration Withdrawal analytical method chronic pain chronic pain management chronic pain patient data mining expectation experience future epidemic heroin use high risk population hospital care injured innovation insight large datasets member military veteran mortality non-opioid analgesic online resource opioid epidemic opioid mortality opioid therapy opioid use overdose death pain patient prescription opioid prevent public health priorities public health relevance racial disparity resilience service organization service providers social social culture social stigma text searching tobacco control tool translational framework trend web site

项目摘要

Abstract/Project Summary Understanding the role of the pharmaceutical industry in propelling the current opioid crisis in the U.S. is an essential strategy for preventing future epidemics. Using multiple forms of textual data and innovative methodologies for data mining and triangulation, this project examines the specific impacts of industry efforts to target military veterans as opioid consumers and analyzes how new industry-driven narratives, or scripts, about opioid analgesics were circulated. Veterans have many vulnerabilities and are one of the populations most severely impacted by the opioid crisis and opioid-related harms, including overdose and HIV/HCV infection. Important documents emerging in litigation against pharmaceutical companies establish that veterans were targeted as an important consumer niche through advocacy groups and paid accounts from veterans about the benefits of opioid therapies. However, only a small portion of the documents currently being revealed in the process of legal discovery have been examined by public health researchers, and very little is currently known about broader industry agendas and the processes by which pro-pharma narratives became part of veteran-specific health discourse, driving attitudes toward opioids and raising barriers to non-opioid pain management. To identify the themes and elucidate the processes by which these scripts were internalized by different veteran populations, this mixed-method research will triangulate large datasets of pharmaceutical industry marketing and legal documentation with veteran-themed publications and the lived experience of chronic pain patients. Findings will be translated into deliverables which positively impact pain management policy, practice, and the attitudes and expectations of veterans with chronic pain. The scientific team includes veterans and scientists at the forefront of uncovering how the tobacco industry targeted military personnel and veterans, along with experts on opioid use and pharmaceutical industry litigation. The systematic textual and content analyses in this study represent a critical case study in pharmaceutical industry efforts to change prescribing policy and popular culture and will serve as an important contribution to literature on the natural history of drug crises and to clinical approaches to pain by achieving the following aims: Aim 1: Use textual mining technology and analytic methods refined by tobacco researchers to explicate the pharmaceutical industry's campaign to influence veterans' (and veterans service organizations') perceptions opioid therapies, particularly within the context of chronic pain management. Aim 2: Conduct qualitative interviews among veterans with histories of pain and opioid use to understand sociocultural meanings and cognitive scripts that impede safe, effective, and medically-appropriate care. Aim 3: Based on a synthesis of data from Aims 1 and 2, conduct T0 and T1 translational research to generate concrete best practices, tools, and web resources to guide clinical and prescriber engagement with veteran and other chronic pain populations.

抽象/项目总结