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Bioengineering core

Bioengineering core
生物工程核心
批准号：
10642594
负责人：
Zahi A. Fayad
金额：
$32.05万
依托单位：
ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
项目状态：
未结题
起止时间：
2023-06-01 至 2028-03-31
来源：
https://reporter.nih.gov/project-details/10642594
关键词：
BiologyBiomedical EngineeringBone MarrowCD8-Positive T-LymphocytesCD8B1 geneCellsChemistryDepositionDevelopmentDoseDrug KineticsEnsureEpigenetic ProcessGlycolysisGoalsHuman ResourcesITGAM geneImageImmuneImmunityImmunoPETImmunotherapeutic agentInterventionLibrariesLiverMass Spectrum AnalysisMetabolicMetabolismModelingMonitorMusMyeloid CellsPositron-Emission TomographyProcessRadioactiveRadiochemistryRadioisotopesRegimenResearchSamplingSpleenTherapeuticTherapeutic StudiesTissuesTrainingTransplantationbiomedical imagingexperienceexperimental studyfluorodeoxyglucosefluorophoreimaging agentimaging probeimaging studyin vivonanobiologicnanobodiesnanolabelnanomaterialsnanomedicinenanotherapeuticnanotherapynovelnuclear imagingpharmacodynamic modelpharmacokinetics and pharmacodynamicsprogramssuccesstherapeutic target

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英文摘要
SUMMARY – CORE B Core B, the Bioengineering Core, will be directed by Dr. Zahi Fayad and serve all three Projects over all five years of the Program. The goals of the Core include: 1) Streamlining all therapeutic experiments by developing and providing trained immunity-inhibiting nanobiologics. 2) Facilitating the nuclear imaging projects by providing immuno-PET probes. 3) Ensuring the safe use and disposal of radioactive materials. The already developed nanobiologics and PET probes will be invaluable for the success of this Program Project. In addition, Core B’s strong chemistry experience will facilitate the development of additional nanotherapies and imaging probes as desired throughout this Project.
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