Pathways to mental health: the mediating role of altered cytokines on the relationship between chronic home radon exposure and emotional neural circuitry in developing youths
心理健康之路:细胞因子改变对长期家庭氡暴露与青少年情绪神经回路之间关系的中介作用
基本信息
- 批准号:10642381
- 负责人:
- 金额:$ 24.45万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2023
- 资助国家:美国
- 起止时间:2023-03-10 至 2025-02-28
- 项目状态:未结题
- 来源:
- 关键词:AddressAdolescentAdolescent DevelopmentAirAreaAttentionAwarenessBehavioralBiological ProcessBlood specimenBrainCarcinogensChild DevelopmentChronicCigaretteClinicalCognitionCognitiveCountryCoupledDangerousnessDataDevelopmentDevelopmental ProcessEmotionalEmotionsEnvironmentEnvironmental HealthExhibitsExposure toFamilyFoundationsFutureGasesGoalsHealthHealth PolicyHomeIncidenceInflammationInflammatoryInvestigationKnowledgeLaboratoriesLinkMagnetic Resonance ImagingMagnetoencephalographyMalignant NeoplasmsMalignant neoplasm of lungMeasurementMeasuresMediatingMental HealthMental disordersNational Institute of Environmental Health SciencesNeurocognitiveNeuropsychologyOrganOutcomeOutcome StudyPathway interactionsPatternPeripheralPersonsProcessPsyche structurePsychometricsPublic HealthRadioactiveRadonRecommendationResearchRiskRoleSeveritiesShapesSmokingSoilSourceStrategic PlanningSystemTechniquesTissuesToxic Environmental SubstancesToxic effectToxinUnited StatesUnited States Environmental Protection AgencyWell in selfWorkYouthbehavioral phenotypingbiological systemsblood-based biomarkerbody systembrain healthcarcinogenicitycognitive abilitycognitive controlcognitive developmentcohortcytokinedepressive symptomsdesignemotion regulationexecutive functionindexinginflammatory markerinnovationmultimodal neuroimagingmultimodalityneuralneural circuitneurodevelopmentneuroimagingphysical conditioningpsychological symptomsoundtoxicant
项目摘要
Abstract
The public at large has grown keenly aware of the effects of environmental toxins on the developing body. Briefly,
exposure to toxicants frequently induces changes in inflammatory activity in the body. That inflammation can
spread systemically and impact multiple organ systems, including the brain. Chronic inflammation, even at low-
grade levels, has been linked to negative mental and cognitive health outcomes, including aberrations in the
development of neural circuitry and the onset and progression of psychological symptoms and disorders.
Knowing the potential effects of such toxins, one surprisingly common, but rarely studied environmental toxin is
radon. Radon is a naturally occurring radioactive gas that accumulates in homes and poses significant health
risks, including increased risk of developing certain cancers, and damage to developmentally sensitive tissues
and organs through accentuated inflammatory processes. The United States Environmental Protection Agency
set the action limit for home radon concentrations at 4 pCi/L, which is the carcinogenic equivalent of smoking 10
cigarettes per day. An astonishing 1 in 15 homes across the country is expected to have radon concentrations
at or above the set action limit, leaving a large number of youths across the country chronically exposed to high
levels of radon. However, studies linking radon toxicity to altered neural and cognitive development are extremely
sparse. The current proposal aims to address this critical gap in knowledge by examining the impact of radon
exposure on inflammatory activity, neural circuitry, and cognitive and mental health function. Our groundbreaking
preliminary work is the first to show robust links between chronic radon exposure and specific inflammatory
activity, coupled with deficits in high order cognition and increased depressive symptomologies. We have also
found evidence that radon exposure is associated with aberrant neural dynamics in a network of frontoparietal
regions that have been commonly implicated in cognitive and emotional control. In the current multimodal
neuroimaging study, we will quantify the impact of home radon exposure on inflammatory processes, and
whether such inflammation has a mediating role on functioning in the distinct neural circuits implicated in emotion
regulation and higher order cognition. To this end,a cohort of adolescents will undergo magnetoencephalography
(MEG) during a battery of tasks designed to assess multiple neural systems serving cognitive and emotional
control. Youths will also complete assessments targeting cognitive and mental health, and provide blood samples
to capture measures of peripheral inflammation. Our specific aims are to 1) identify the impact of chronic radon
exposure on the neural circuitry implicated in emotional and cognitive control, and 2) quantify the mediating role
of inflammatory processes through which radon alters neural circuitry and behavioral phenotypes in youths. The
outcomes of this study have the potential to shape the future of public health policy surrounding radon awareness
and mitigation efforts, and this is especially true in the local region where home radon levels are some of the
highest in the nation.
摘要
项目成果
期刊论文数量(0)
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科研奖励数量(0)
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Brittany Taylor其他文献
Brittany Taylor的其他文献
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{{ truncateString('Brittany Taylor', 18)}}的其他基金
Cognitive, Immunological, and Neurophysiological Consequences of Home Radon Exposure in Children and Adolescents
儿童和青少年家庭氡暴露的认知、免疫和神经生理学后果
- 批准号:
10346726 - 财政年份:2022
- 资助金额:
$ 24.45万 - 项目类别:
Cognitive, Immunological, and Neurophysiological Consequences of Home Radon Exposure in Children and Adolescents
儿童和青少年家庭氡暴露的认知、免疫和神经生理学后果
- 批准号:
10580780 - 财政年份:2022
- 资助金额:
$ 24.45万 - 项目类别:
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