TOPIC 425 - AUTOMATED MOTION EXTRACTION AND ANALYSIS TO QUANTIFY PATIENT PERFORMANCE STATUS

主题 425 - 自动运动提取和分析以量化患者表现状态

• 批准号: 10647610
• 负责人: LUCIANO NOCERA
• 金额: $ 193.79万
• 依托单位: CANSERA, INC.
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-15 至 2024-06-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10647610
• 关键词: Acceleration; Address; Architecture; Biological Markers; Calibration; Clinic; Clinical; Clinical Trials; Computer software; Custom; Data; Data Collection; Data Set; Eastern Cooperative Oncology Group; Ensure; Evaluation; Human; Image; Image Analysis; Joints; Karnofsky Performance Status; Libraries; Lighting; Location; Malignant Neoplasms; Manuals; Measurement; Measures; Methods; Motion; Movement; Output; Patients; Performance; Performance Status; Phase; Procedures; Process; Reproducibility; Resolution; Series; Site; Skeleton; Small Business Innovation Research Grant; Software Design; Specific qualifier value; Stream; Testing; Therapeutic Intervention; Time; Vertebral column; base; cancer care; commercial application; dashboard; data acquisition; data management; design; kinematics; predictive marker; software development; technical report; temporal measurement

The Karnofsky score (1948) and the Eastern Cooperative Group ECOG PS (1982) are the standard for patient PS assessment and used as a key determinant for entry into a clinical trial and the initiation or continuation of any interventional therapy. Cansera has demonstrated using image analysis of footage from RGB-D cameras to quantify PS as a predictive biomarker in cancer care. RGB-D cameras captured patients performing a physical task in a clinic and patient movement is analyzed to predict PS. The phase I SBIR proposal will address the following technical challenges: 1) creating a reproducible method for data acquisition and extraction from RGB-D cameras; 2) developing a strategy for anonymizing RGB-D image dataset for an open access library; and 3) establishing requirements and designing for different user groups. The successful completion of the project will enable commercial application for a reproducible anonymized method for data acquisition and image capture using a RGB-D camera to objectively measure human performance providing a quantitative solution.

Karnofsky评分（1948）和东部协作组ECOG PS（1982）是患者PS评估的标准，并用作进入临床试验和开始或继续任何介入治疗的关键决定因素。Cansera已经展示了使用RGB-D相机的图像分析来量化PS作为癌症护理中的预测生物标志物。RGB-D摄像机捕获在诊所中执行物理任务的患者，并分析患者运动以预测PS。第一阶段SBIR提案将解决以下技术挑战：1）创建从RGB-D相机获取和提取数据的可重复方法; 2）为开放获取库开发RGB-D图像数据集匿名化策略; 3）为不同用户群体制定要求和设计。该项目的成功完成将使商业应用的数据采集和图像捕获使用RGB-D相机，客观地再现匿名方法， 衡量人的绩效，提供定量解决方案。