Admin Supplemental for ADRC Core D

摘要/摘要 复杂神经退行性疾病的预防、诊断和治疗的科学进展 神经精神和神经发育障碍依赖于有良好注释和 对死后的人脑组织样本进行分类。为了最大限度地利用社区来源的大脑捐赠 来自阿尔茨海默病(AD)、血管性痴呆、不明原因痴呆和认知正常的患者 作为对照，成立了一个工作组，以探索NIH神经生物库之间可能的合作 (NBB)网络和阿尔茨海默病研究中心(ADRC)神经病理核心(NP核心)。目标是 这一合作的主要目的是通过整合和利用 现有基础设施。2019年，匹兹堡大学ADRC(PITT-ADRC)被选为三所 这一项目的试点地点，目的是建立资格标准、招聘程序和标准 使数据收集和组织分发机制与NBB协议保持一致的操作程序。 我们提出的实现ADRC-NBB试点项目目标的方法概述如下 具体目标：1)制定和实施通过脑捐赠者项目招募脑捐赠者的战略 进入ADRC神经病理核心网络。2)执行详细的神经病理诊断评估 使用最先进的共识标准将案件存入银行，并向家庭提供反馈。3)获得临床应用 符合NIH NBB协议的信息和辅助实验室测试。4)上传人口统计、临床 和神经病理数据添加到NIH NBB病例目录。5)将组织样本分发给研究界 回应通过NIH神经生物库门户网站收到的请求。6)增强银行、神经病理 匹兹堡大学典型尸检病例的NACC数据共享和组织分布 研究参与者和患有神经退行性疾病的医院患者。 通过这些目标，并与其他试验点合作，我们将展示 建立ADRC NP核心，作为NIH NBB网络的附属站点，并制定简化的程序 对非ADRC案例的银行业务。我们的最终方案将提供给更广泛的ADRC社区，以 允许其他感兴趣的NP核心加入此协作Brain Bank计划，进一步最大化Brain 捐款。此外，我们将增加患有AD和相关痴呆的非ADRC受试者的脑捐赠 来自当地神经科诊所和研究队列，重点放在先前有神经成像的受试者身上 研究，利用最近在国家阿尔茨海默病协调中心创建的简短数据集 (NACC)以增加更广泛的研究界对这些病例的可及性，并促进组织共享。

Summary/Abstract Scientific progress towards prevention, diagnosis and treatment of complex neurodegenerative, neuropsychiatric and neurodevelopmental disorders is dependent on the availability of well-annotated and catalogued postmortem human brain tissue samples. In order to maximize community-derived brain donations from patients with Alzheimer’s disease (AD), vascular dementia, unspecified dementia and cognitively normal controls, a working group was established to explore a possible collaboration between the NIH Neurobiobank (NBB) network and Alzheimer’s disease research center (ADRC) neuropathology cores (NP core). The objective of this collaboration is to optimize access to high-quality tissue samples by integrating and taking advantage of existing infrastructures. In 2019, the University of Pittsburgh ADRC (PITT-ADRC) was chosen as one of three pilot sites for this project, with the goal to establish eligibility criteria, recruitment processes and standard operating procedures to align data collection and tissue distribution mechanisms with NBB protocols. Our proposed approach to fulfill the goals of this ADRC-NBB pilot project is outlined in the following six specific aims: 1) Develop and implement a strategy to recruit brain donations through the Brain Donor Project into the ADRC neuropathology core network. 2) Perform detailed neuropathological diagnostic evaluations of all banked cases using state-of-the-art consensus criteria and provide feedback to families. 3) Obtain clinical information and ancillary laboratory tests in alignment with NIH NBB protocols. 4) Upload demographic, clinical and neuropathology data to the NIH NBB case catalog. 5) Distribute tissue samples to the research community in response to requests received through the NIH Neurobiobank portal. 6) Enhance the banking, neuropathology data sharing via NACC and tissue distribution of well-characterized autopsy cases from University of Pittsburgh research study participants and hospital patients with neurodegenerative disorders. Through these aims and in collaboration with the other pilot sites, we will demonstrate the feasibility of establishing ADRC NP cores as affiliate sites of the NIH NBB network and of developing a streamlined process to banking of non-ADRC cases. Our finalized approach will be made available to the wider ADRC community to allow other interested NP cores to join this collaborative brain banking program and further maximize brain donations. In addition, we will enhance brain donations from non-ADRC subjects with AD and related dementias from local neurology clinics as well as research cohorts with strong emphasis on subjects with prior neuroimaging studies, taking advantage of the recently created Brief Data Set at the National Alzheimer Coordinating Center (NACC) to increase accessibility to these cases by the wider research community and to promote tissue sharing.