Admin Supplemental for ADRC Core D

ADRC Core D 的管理补充

• 批准号: 10652889
• 负责人: Oscar L. Lopez
• 金额: $ 26.73万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-05-15 至 2025-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10652889
• 关键词: Administrative Supplement; Alzheimer' s Disease; Alzheimer' s disease brain; Alzheimer' s disease patient; Alzheimer' s disease related dementia; Autopsy; Brain; Brain Diseases; Cataloging; Catalogs; Clinic; Clinical; Cognitive; Collaborations; Collection; Communication; Communities; Complex; Consensus; Data; Data Collection; Data Set; Dementia; Development; Diagnosis; Diagnostic; Drug or chemical Tissue Distribution; Eligibility Determination; Evaluation; Faculty; Family; Feedback; Funding; Goals; Hospitals; Human; Individual; Infrastructure; Laboratories; Neurodegenerative Disorders; Neurodevelopmental Disorder; Neurology; Participant; Patients; Pilot Projects; Prevention; Procedures; Process; Protocols documentation; Recording of previous events; Research; Resources; Scientific Advances and Accomplishments; Site; Standardization; Testing; Tissue Banks; Tissue Sample; Tissues; Underrepresented Minority; United States National Institutes of Health; Universities; Vascular Dementia; Washington; Work; biobank; brain tissue; cohort; community center; data sharing; interest; meetings; minority subjects; nervous system disorder; neuroimaging; neuropathology; neuropsychiatric disorder; preference; programs; recruit; research study; response; working group

Summary/Abstract Scientific progress towards prevention, diagnosis and treatment of complex neurodegenerative, neuropsychiatric and neurodevelopmental disorders is dependent on the availability of well-annotated and catalogued postmortem human brain tissue samples. In order to maximize community-derived brain donations from patients with Alzheimer’s disease (AD), vascular dementia, unspecified dementia and cognitively normal controls, a working group was established to explore a possible collaboration between the NIH Neurobiobank (NBB) network and Alzheimer’s disease research center (ADRC) neuropathology cores (NP core). The objective of this collaboration is to optimize access to high-quality tissue samples by integrating and taking advantage of existing infrastructures. In 2019, the University of Pittsburgh ADRC (PITT-ADRC) was chosen as one of three pilot sites for this project, with the goal to establish eligibility criteria, recruitment processes and standard operating procedures to align data collection and tissue distribution mechanisms with NBB protocols. Our proposed approach to fulfill the goals of this ADRC-NBB pilot project is outlined in the following six specific aims: 1) Develop and implement a strategy to recruit brain donations through the Brain Donor Project into the ADRC neuropathology core network. 2) Perform detailed neuropathological diagnostic evaluations of all banked cases using state-of-the-art consensus criteria and provide feedback to families. 3) Obtain clinical information and ancillary laboratory tests in alignment with NIH NBB protocols. 4) Upload demographic, clinical and neuropathology data to the NIH NBB case catalog. 5) Distribute tissue samples to the research community in response to requests received through the NIH Neurobiobank portal. 6) Enhance the banking, neuropathology data sharing via NACC and tissue distribution of well-characterized autopsy cases from University of Pittsburgh research study participants and hospital patients with neurodegenerative disorders. Through these aims and in collaboration with the other pilot sites, we will demonstrate the feasibility of establishing ADRC NP cores as affiliate sites of the NIH NBB network and of developing a streamlined process to banking of non-ADRC cases. Our finalized approach will be made available to the wider ADRC community to allow other interested NP cores to join this collaborative brain banking program and further maximize brain donations. In addition, we will enhance brain donations from non-ADRC subjects with AD and related dementias from local neurology clinics as well as research cohorts with strong emphasis on subjects with prior neuroimaging studies, taking advantage of the recently created Brief Data Set at the National Alzheimer Coordinating Center (NACC) to increase accessibility to these cases by the wider research community and to promote tissue sharing.

摘要/摘要 朝着预防，诊断和治疗复杂神经退行性的科学进步， 神经精神病学和神经发育障碍取决于宣布良好的可用性和 验尸后人脑组织样品。为了最大化社区衍生的大脑捐赠 来自阿尔茨海默氏病（AD），血管痴呆，未指定痴呆和认知正常的患者 控件，建立了一个工作组，以探索NIH Neurobiobank之间的可能协作 （NBB）网络和阿尔茨海默氏病研究中心（ADRC）神经病理学核心（NP Core）。目标 这种合作是通过集成和利用优化的优化高质量组织样品的访​​问 现有的基础架构。 2019年，匹兹堡大学ADRC（PITT-ADRC）被选为三个 该项目的试点站点，旨在建立资格标准，招聘流程和标准 将数据收集和组织分布机制与NBB方案相结合的操作程序。 我们提出的实现此ADRC-NBB飞行员项目目标的方法在以下六个 具体目的：1）制定并实施通过大脑供体项目招募大脑捐赠的策略 进入ADRC神经病理学核心网络。 2）对所有人进行详细的神经病理诊断评估 使用最新的共识标准对案件进行了存储，并向家庭提供了反馈。 3）获得临床 与NIH NBB协议对齐的信息和辅助实验室测试。 4）上传人群，临床 NIH NBB病例目录的神经病理学数据。 5）向研究界分发组织样品 响应通过NIH Neurobiobank门户收到的请求。 6）增强银行业，神经病理学 通过NACC和组织分布的数据共享和匹兹堡大学的尸检病例的组织分布 研究研究参与者和神经退行性疾病的患者。 通过这些目标并与其他试点站点合作，我们将证明 将ADRC NP核心建立为NIH NBB网络的会员站点，并开发精简过程 非ADRC案件的银行。我们的最终方法将提供给更广泛的ADRC社区 允许其他有趣的NP核心加入该协作的大脑银行计划，并进一步最大化大脑 捐赠。此外，我们将增强AD和相关痴呆症的非ADRC受试者的大脑捐赠 来自本地神经病学诊所以及研究队列，并非常重视先前神经影像学的受试者 研究，利用最近在国家阿尔茨海默氏症协调中心创建的简短数据集 （NACC）为更广泛的研究界增加对这些案例的可访问性并促进组织共享。