Biomarkers of Kaposi sarcoma recrudescence in Zambia

赞比亚卡波西肉瘤复发的生物标志物

• 批准号: 10649926
• 负责人: Owen Ngalamika
• 金额: $ 10万
• 依托单位: UNIVERSITY OF ZAMBIA
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-16 至 2024-10-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10649926
• 关键词: AIDS related cancer; AIDS/HIV problem; Affect; African; Age; Age-Years; Area; Asia; Biological Markers; CD4 Positive T Lymphocytes; CD8-Positive T-Lymphocytes; Cancer Patient; Chronic; Clinical; Country; Developed Countries; Developing Countries; Development; Disease; Elderly; Environment; Ethics; Etiology; Functional disorder; Goals; HIV; HIV Infections; HIV Seronegativity; HPV-High Risk; Histologic; Histopathologic Grade; Human; Human Papillomavirus; Human papilloma virus infection; Hygiene; Immune; Immune System Diseases; Immune response; Immunohistochemistry; Immunologic Markers; Immunologic Surveillance; Immunophenotyping; Impairment; Incidence; Individual; Infection; Inflammaging; Inflammatory; Kaposi Sarcoma; Lead; Lesion; Malignant Neoplasms; Malignant neoplasm of penis; Mentors; Mentorship; Outcome; Participant; Patients; Penile Neoplasms; Persons; Phimosis; Play; Prevalence; Recrudescences; Research Design; Research Personnel; Risk; Role; Sexually Transmitted Diseases; Site; Skin Tissue; Smoking; South America; Standardization; Subgroup; T memory cell; T-Cell Depletion; Teaching Hospitals; Training; Trauma; Tumor-Infiltrating Lymphocytes; Universities; Urologist; Viral Load result; Zambia; antiretroviral therapy; co-infection; exhaustion; immune reconstitution; immunosenescence; improved; laboratory experiment; male; men; mortality; penis; premature; prevent; programmed cell death ligand 1; programmed cell death protein 1; recruit; responsible research conduct; sexually active; sociodemographics; tumor; tumor progression

PROJECT SUMMARY/ABSTRACT The “Role of Human papiloma vírus and HIV in Penile Cancer Progression” study will investigate the association between presence of human papilloma virus (HPV) in penile cancer tumors and HIV co-infection with stage at presentation of penile cancer. Penile cancer is an aggressive malignancy that develops in the skin and tissues of the penis. The etiology of penile cancer is not completely understood. However, several factors including infections (HIV, Human Papillomavirus (HPV), other sexually transmitted infections), poor hygiene, advanced age, smoking, trauma, and inflammatory conditions have been associated with penile cancer development. In our setting, penile cancer patients present at a much younger age, and mostly among HIV infected individuals, than in developed countries. Even though HPV is associated with penile cancer, the presence of HPV in penile cancer ranges from 20-80%. Despite HPV being thought to play a role in penile cancer development, some studies have found that the presence of high-risk HPV in penile tumors is associated with a better outcome. The main objective of this study is to investigate the role of HPV and HIV in penile cancer progression, and to recruit and train an early investigator in the area of HIV-associated malignancies. The site for this study has a high incidence of penile cancer patients. The long-term goal of this study is to determine how the immune response can be utilized in order to limit the progression of penile cancer. Three specific aims will be accomplished: 1) Recruit, support, and mentor Dr. Victor Mapulanga to Study Penile Cancer; 2) Recruit and characterize penile cancer patients clinically, histologically, and by HPV status; and 3) Compare the presence of tumor infiltrating lymphocytes, resident memory T cells, and markers of immune exhaustion in penile tumors by HPV and HIV status. In summary, this study will investigate the role of HPV and HIV in penile cancer stage at presentation.

项目总结/摘要 “人类乳头状瘤病毒和艾滋病毒在阴茎癌进展中的作用”研究将调查 阴茎癌肿瘤中人乳头瘤病毒（HPV）的存在与HIV合并感染之间的关系 阴茎癌的分期阴茎癌是一种侵袭性的恶性肿瘤， 阴茎的皮肤和组织。阴茎癌的病因尚未完全了解。但几 因素包括感染（艾滋病毒、人乳头瘤病毒（HPV）、其他性传播感染）、贫穷、 卫生、高龄、吸烟、创伤和炎症与阴茎有关 癌症发展在我们的环境中，阴茎癌患者的年龄要小得多，而且大多数是在 艾滋病病毒感染者，比发达国家。尽管HPV与阴茎癌有关， HPV在阴茎癌中的存在范围为20- 80%。尽管HPV被认为在阴茎中起作用， 癌症的发展，一些研究发现，在阴茎肿瘤中存在高危型HPV， 与更好的结果相关。本研究的主要目的是调查HPV和HIV在 阴茎癌进展，并招募和培训艾滋病毒相关领域的早期研究人员， 恶性肿瘤本研究中心的阴茎癌患者发病率较高。长期目标是 这项研究的目的是确定如何利用免疫反应来限制阴茎的进展， 癌将实现三个具体目标：1）招募、支持和指导维克托马普兰加博士， 研究阴茎癌; 2）招募和表征阴茎癌患者的临床、组织学和HPV 状态;和3）比较肿瘤浸润淋巴细胞、驻留记忆T细胞和标记物的存在 HPV和HIV感染状态对阴茎肿瘤免疫衰竭的影响总之，本研究将研究 HPV和HIV在阴茎癌中的作用