A Unique, Co-Designed Family-Based Therapy for Marginalized Women with Opioid Use Disorder and Justice-Involvement

项目摘要/摘要 Aaron Murnan，LMFT博士，辛辛那提大学学院终身教职助理教授 护士。他的职业目标是成为一名独立的临床科学家，拥有共同设计小说的专业知识。 干预措施以满足受阿片类药物使用不成比例影响的家庭的显著治疗需求 正义--参与，特别是涉及性交易的妇女。术语“共同设计”指的是以社区为基础的 参与式研究方法，以有生活经验的个人为研究团队 各成员提供他们的实践专业知识，并彻底参与干预措施的制定过程。 鉴于有据可查的与性交易和阿片类药物使用相关的风险，以及缺乏干预措施 这项研究旨在应对这一人群所经历的挑战，目前的研究代表了一项 在促进性交易中妇女的健康和福祉方面迈出关键的下一步。建议的五项建议如下： 年导师以患者为导向的研究职业发展奖(K23)将为Murnan博士提供完美的 通过以下培训实现其职业目标的机会：1)基于社区的参与性研究；2) 适应--ITT物质使用干预适应方法；以及3)在 刑事司法系统。默南博士提议的研究旨在评估联合治疗的可行性和可接受性。 设计了以家庭为基础的干预措施，作为治疗分流规划的辅助手段(通过 刑事司法系统)，使用试点区域合作研究设计。在目标1中，参与者家庭二人组(n=15名妇女配对 与一名支持的家庭成员)将被招募来探索干预需求、动机和障碍 与参与以家庭为基础的干预以及分娩偏好有关。这一信息将是 由联合设计团队(有实际经验的个人、PI和其他研究人员)使用，以适应 以家庭为基础的干预手册。对于目标2，将招募更多的家庭二人组(n=60)参加 随机对照试验，他们将被随机分配到两个治疗组中的一个：1)联合 设计家庭干预+分流治疗规划或2)分流治疗规划 只有这样。将评估这两种干预措施的可行性、可接受性和初步效果(目标2)。Dr。 梅林达·布奇·科瓦契奇是以社区为基础的参与性研究的主要专家，她将担任Dr。 穆尔南的主要网站导师。Butsch Kovacic博士与他的合作导师(Jennifer Brown博士和 Sarah Manchak)将在基于社区的参与性研究领域为他提供必要的培训， 物质使用干预适应方法，并在刑事司法领域内开展研究 系统，这将开启他作为临床医生科学家的独立研究生涯，拥有必要的技能 进行高质量的干预研究，以不成比例地促进家庭的最佳结果 受阿片类药物使用和刑事司法介入的影响。

Project Summary/Abstract Aaron Murnan, PhD, LMFT is a tenure-track assistant professor at University of Cincinnati's College of Nursing. His career goal is to become an independent clinician-scientist with expertise in co-designing novel interventions to address salient treatment needs among families disproportionately impacted by opioid use and justice-involvement, specifically women in the sex trade. The term `co-design' refers to a community-based participatory research methodology in which individuals with lived experience are engaged as study team members to lend their hands-on expertise and thoroughly participate in the intervention development process. Given well-documented risks associated with the sex trade and opioid use, as well as a lack of interventions prospectively designed to address challenges experienced by this population, the current study represents a critical next step towards promoting the health and well-being of women in the sex trade. The proposed five- year Mentored Patient-Oriented Research Career Development Award (K23) will provide Dr. Murnan a perfect opportunity to achieve his career goals through training in: 1) Community-Based Participatory Research; 2) ADAPT-ITT substance use intervention adaptation methodologies; and 3) conducting research within the criminal justice system. Dr. Murnan's proposed study aims to evaluate the feasibility and acceptability of co- designed family-based intervention offered as an adjunct to treatment diversion programming (offered through the criminal justice system) using a pilot RCT design. In Aim 1, participant family dyads (n=15 women paired with one supportive family member) will be recruited to explore intervention needs, motivations, and barriers related to participating in family-based intervention, as well as delivery preferences. This information will be used by the co-design team (individuals with lived experience, the PI, and other research personnel) to adapt a family-based intervention manual. For Aim 2, additional family dyads (n=60) will be recruited to participate in a randomized controlled trial in which they will be randomly assigned to one of two treatment arms: 1) co- designed family-based intervention + diversion treatment programming or 2) diversion treatment programming only. Feasibility, acceptability, and preliminary efficacy of both interventions will be evaluated (Aim 2). Dr. Melinda Butsch Kovacic, a leading expert in community-based participatory research, will serve as Dr. Murnan's primary site mentor. Dr. Butsch Kovacic in conjunction with his co-mentors (Drs. Jennifer Brown and Sarah Manchak) will provide him with necessary training in areas of community-based participatory research, substance use intervention adaptation methodologies, and conducting research within the criminal justice system, that will launch his independent research career as a clinician scientist with the requisite skills to conduct high quality intervention research to promote best outcomes among families disproportionately impacted by opioid use and criminal justice involvement.