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Coordination for ARDS, Pneumonia, and Sepsis supporting Training, Organization and Network Efficiency (CAPSTONE)

协调 ARDS、肺炎和败血症支持培训、组织和网络效率 (CAPSTONE)

基本信息

批准号：
10647455
负责人：
Gordon R Bernard
金额：
$ 228.71万
依托单位：
VANDERBILT UNIVERSITY MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-05-01 至 2029-04-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10647455
关键词：
Acute Respiratory Distress Syndrome Adherence Attenuated Big Data Biological Biometry California Caring Classification Clinical Clinical Research Clinical Trials Data Monitoring Committees Cognitive Communication Communities Compensation Complex Contracts Critical Illness Data Data Collection Dedications Development Electronic Health Record Enrollment Ensure Evolution Failure Foundations Goals Grouping Heterogeneity Image Individual Infrastructure Investigation Knowledge Leadership Manuals Measurement Measures Medical Methods Mission Monitor Morbidity - disease rate Operations Research Outcome Participant Patients Pharmacotherapy Phenotype Pneumonia Population Precision therapeutics Process Protocols documentation Recovery Reporting Reproducibility Research Research Design Research Infrastructure Risk Factors San Francisco Science Security Sepsis Site Standardization Statistical Data Interpretation Syndrome Therapeutic Training Training Support Translating Translational Research Trust Universities Work biobank career development clinical center cohort community engagement data infrastructure data management data modeling data quality design efficacious treatment electronic consent experience improved individual patient innovation knowledge base mortality multimodality novel therapeutics operation patient population patient subsets performance site personalized management phenotyping algorithm point of care precision medicine profiles in patients prognostic protocol development recruit skill acquisition skills success synergism targeted treatment treatment response virtual

项目摘要

The ARDS, Pneumonia, and Sepsis (APS) Coordinating Center will support a highly functional and integrated clinical and translational research infrastructure that will enhance the quality and scientific rigor of the research conducted by the APS Phenotyping Consortium. We are a team composed of leading content and methods experts at Vanderbilt, Johns Hopkins, and University of California San Francisco. We will provide Coordination for ARDS, Pneumonia, and Sepsis supporting Training, Organization and Network Efficiency: ‘CAPSTONE’. We will support the clinical centers (CCs) in enrolling and sustaining a diverse cohort; enable the efficient and standardized capture of multi-modal cohort data with repeated measurements; model the data to understand mechanistic underpinnings of APS, including the interplay of underlying and static risk factors; and segment the population into similar prognostic and predictive phenotypes. This will enable scientific progress towards a deeper mechanistic understanding of critical illness syndromes and recovery. Functionally, we will 1) Implement the study design, data capture, and statistical analysis unit. Coordinate protocol development; establish a REDCap-based data collection, management, and security framework; conduct and support analyses; generate reports; make curated data widely available for research through a facilitated storefront; 2) Implement the clinical research management unit. Maintain cohort integrity and adherence to the protocol and manual of operations, perform routine monitoring of data quality and site performance; training of study staff; image and biospecimen management. Support site communications; facilitate recruitment and retention; and 3) Implement the stakeholder engagement and development unit. Establish bidirectional, longitudinal engagement from diverse communities; help CCs build and sustain trust; ensure strengths of each CC are nurtured and shared; facilitate dissemination of findings; support skills and career development among research teams. Our efforts will expand foundational work on APS phenotyping, identify gaps, and help create methods for redefining critical illness syndromes with the ultimate goal of improving and personalizing management strategies that will curtail the devastating morbidity and mortality caused by APS.

ARDS，肺炎和败血症（APS）协调中心将支持一个高度功能性的