Molecular epidemiology of respiratory virus exposure in elementary schools
小学呼吸道病毒暴露的分子流行病学
基本信息
- 批准号:10646577
- 负责人:
- 金额:$ 26.79万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2023
- 资助国家:美国
- 起止时间:2023-02-10 至 2025-01-31
- 项目状态:未结题
- 来源:
- 关键词:AdenovirusesAdherenceAffectAirAsthmaBehaviorCOVID-19COVID-19 outbreakCOVID-19 patientCarbon DioxideChildChildhoodContact TracingCoronavirusDataDetectionDisease OutbreaksDisinfectantsDustEnterovirusEnvironmentEnvironmental HealthEnvironmental Risk FactorExposure toFatigueFutureGeneticGenomeGoalsHandwashingHomeHospitalizationHouseholdHumanHumidityHybridsIncidenceIndividualIndoor environmentInfluenza A virusInfrastructureInterventionIntervention StudiesMandatory ReportingMasksMeaslesMetadataMetapneumovirusMethodsMissionMolecular EpidemiologyMorbidity - disease rateMorbillivirusMumps virusParainfluenzaParticulatePathogenicityPlacebo ControlPredictive FactorRandomized, Controlled TrialsResearchRespiratory syncytial virusRhinovirusRiskRubella virusSARS coronavirusSamplingSchoolsSourceSpainStudentsSurfaceSymptomsTemperatureTestingTimeUnited StatesUnited States National Institutes of HealthVaccinesViralViral GenomeViral Respiratory Tract InfectionWorkair filtrationbuilt environmentdesigndisease transmissioneffective interventionelementary schoolenvironmental interventionevidence basehigh efficiency particulate air filterhigh riskinfluenzavirusinner cityinnovationmetagenomic sequencingnext generation sequencingnovel strategiespandemic diseasepandemic influenzapathogenportabilityprotective behaviorpublic health interventionrandomized placebo controlled trialreconstructionrespiratoryrespiratory infection virusrespiratory virussample collectionschool environmentventilationvirome
项目摘要
PROJECT SUMMARY/ABSTRACT
There is a fundamental gap in understanding the extent to which the school environment contributes to
respiratory virus exposure, and less is known about potential environmental interventions to reduce exposure.
Our long-term goal is to create healthy indoor school environments for children. The overall objective of this
application is to identify modifiable factors of respiratory virus exposure in elementary schools in order to
reduce asthma morbidity. We will combine novel approaches to quantify and characterize the respiratory
virome in schools by leveraging the robust infrastructure of the School Inner-City Asthma Intervention Study
(SICAS-2, ClinicalTrials.gov NCT02291302), a randomized controlled trial conducted by our group of a
placebo-controlled classroom high efficiency particulate air (HEPA) cleaner intervention. We will test our
central hypothesis that schools are a source of high respiratory virus exposure that affects asthma morbidity
through the following specific aims: (1) To compare respiratory virus exposure in schools as compared to
homes by using a hybrid capture panel to recover genomes of detected respiratory viruses; (2) To identify
factors predicting respiratory virus exposure in schools including the efficacy of portable HEPA cleaners in
reducing classroom respiratory virus exposure; (3) To determine the association between the classroom
respiratory virome and asthma symptoms in elementary school children. The approach is innovative, because
we are simultaneously interrogating all major human respiratory viruses in the school environment. The
proposed research is significant, because it will identify the magnitude of exposure to respiratory viruses in
schools and potential environmental factors that can serve as future targets of intervention. If the HEPA
intervention can reduce respiratory virus exposure, it is an immediately actionable and practical intervention to
create safer indoor environments for elementary school children. Results from this proposal may be
generalizable to other public indoor settings.
项目摘要/摘要
在理解学校环境在多大程度上有助于
与呼吸道病毒接触有关,对减少接触的潜在环境干预知之甚少。
我们的长期目标是为孩子们创造健康的室内学校环境。这样做的总体目标是
应用是确定小学呼吸道病毒暴露的可改变因素,以便
降低哮喘发病率。我们将结合新的方法来量化和表征呼吸道
利用市内学校哮喘干预研究的强大基础设施在学校中传播病毒
(SICAS-2,ClinicalTrials.gov NCT02291302),由我们小组进行的随机对照试验
安慰剂对照教室高效颗粒物空气净化器干预。我们将测试我们的
中心假设是学校是影响哮喘发病率的高呼吸道病毒暴露的来源
通过以下具体目标:(1)比较学校接触呼吸道病毒与
通过使用混合捕获面板恢复检测到的呼吸道病毒的基因组;(2)识别
预测学校呼吸道病毒暴露的因素包括便携式HEPA清洁剂在
减少课堂呼吸道病毒暴露;(3)确定课堂与
小学生呼吸道病毒和哮喘症状。这种方法是创新的,因为
我们正在同时审问学校环境中所有主要的人类呼吸道病毒。这个
拟议的研究意义重大,因为它将确定在中国接触呼吸道病毒的程度。
学校和可能成为未来干预目标的环境因素。如果HEPA
干预可以减少呼吸道病毒的暴露,是一种立即可操作和切实可行的干预措施
为小学生创造更安全的室内环境。这项提议的结果可能是
可推广到其他公共室内环境。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Peggy Sue Lai其他文献
Peggy Sue Lai的其他文献
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{{ truncateString('Peggy Sue Lai', 18)}}的其他基金
High efficiency particulate air cleaner intervention to reduce respiratory virus exposure in elementary schools
高效颗粒空气净化器干预减少小学呼吸道病毒暴露
- 批准号:
10722583 - 财政年份:2023
- 资助金额:
$ 26.79万 - 项目类别:
The school microbiome and asthma morbidity in inner-city children
内城区儿童的学校微生物组和哮喘发病率
- 批准号:
10065492 - 财政年份:2019
- 资助金额:
$ 26.79万 - 项目类别:
The school microbiome and asthma morbidity in inner-city children
内城区儿童的学校微生物组和哮喘发病率
- 批准号:
10541838 - 财政年份:2019
- 资助金额:
$ 26.79万 - 项目类别:
The school microbiome and asthma morbidity in inner-city children
内城区儿童的学校微生物组和哮喘发病率
- 批准号:
10317083 - 财政年份:2019
- 资助金额:
$ 26.79万 - 项目类别:
Endotoxin, the airway transcriptome, and obstructive lung disease
内毒素、气道转录组和阻塞性肺病
- 批准号:
9066670 - 财政年份:2013
- 资助金额:
$ 26.79万 - 项目类别:
Endotoxin, the airway transcriptome, and obstructive lung disease
内毒素、气道转录组和阻塞性肺病
- 批准号:
8852128 - 财政年份:2013
- 资助金额:
$ 26.79万 - 项目类别:
Endotoxin, the airway transcriptome, and obstructive lung disease
内毒素、气道转录组和阻塞性肺病
- 批准号:
8739644 - 财政年份:2013
- 资助金额:
$ 26.79万 - 项目类别:
Endotoxin, the airway transcriptome, and obstructive lung disease
内毒素、气道转录组和阻塞性肺病
- 批准号:
8617465 - 财政年份:2013
- 资助金额:
$ 26.79万 - 项目类别:
Lung disease due to chronic endotoxin exposure in mouse and human models
小鼠和人类模型中慢性内毒素暴露引起的肺部疾病
- 批准号:
8608942 - 财政年份:2012
- 资助金额:
$ 26.79万 - 项目类别:
Lung disease due to chronic endotoxin exposure in mouse and human models
小鼠和人类模型中慢性内毒素暴露引起的肺部疾病
- 批准号:
8252322 - 财政年份:2012
- 资助金额:
$ 26.79万 - 项目类别:
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